Cellular Coupling And Conducted Vasomotor Responses
SUMMARY 1. The present brief review examines the concept of spreading vasodilator responses in arteriolar trees, its physiological relevance and possible mechanisms. 2. The most likely mechanisms involve spread of hyperpolarization through tissues in the vessel wall, made possible by electrical coup...
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| Veröffentlicht in: | Clinical and Experimental Pharmacology and Physiology 2002-07, Vol.29 (7), p.626-629 |
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| container_title | Clinical and Experimental Pharmacology and Physiology |
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| creator | Neild, TO Crane, GJ |
| description | SUMMARY
1. The present brief review examines the concept of spreading vasodilator responses in arteriolar trees, its physiological relevance and possible mechanisms.
2. The most likely mechanisms involve spread of hyperpolarization through tissues in the vessel wall, made possible by electrical coupling between the cells. It is generally agreed that there is coupling between cells within the muscle and endothelial layers, but coupling between the two layers is not always present.
3. The passive electrical properties of arterioles can be modelled, using different techniques depending on the complexity of branching of the arteriolar tree. Comparison of experimental results with the model indicates that hyperpolarization can spread further than expected from passive properties alone, implying that spreading vasodilatation may be an active process. |
| doi_str_mv | 10.1046/j.1440-1681.2002.03700.x |
| format | Article |
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1. The present brief review examines the concept of spreading vasodilator responses in arteriolar trees, its physiological relevance and possible mechanisms.
2. The most likely mechanisms involve spread of hyperpolarization through tissues in the vessel wall, made possible by electrical coupling between the cells. It is generally agreed that there is coupling between cells within the muscle and endothelial layers, but coupling between the two layers is not always present.
3. The passive electrical properties of arterioles can be modelled, using different techniques depending on the complexity of branching of the arteriolar tree. Comparison of experimental results with the model indicates that hyperpolarization can spread further than expected from passive properties alone, implying that spreading vasodilatation may be an active process.</description><identifier>ISSN: 0305-1870</identifier><identifier>EISSN: 1440-1681</identifier><identifier>DOI: 10.1046/j.1440-1681.2002.03700.x</identifier><identifier>PMID: 12060108</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Science Pty</publisher><subject>arteriole ; Arterioles - physiology ; cable properties ; connexin ; electrical coupling ; endothelium ; Endothelium, Vascular - physiology ; gap junction ; Humans ; Membrane Potentials - physiology ; Muscle, Smooth, Vascular - physiology ; smooth muscle ; vasodilatation ; vasodilation ; Vasodilation - physiology</subject><ispartof>Clinical and Experimental Pharmacology and Physiology, 2002-07, Vol.29 (7), p.626-629</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4030-9c2a3e3c991e6ac45ec3105c0e5585b921ce4a2712edf1582fca989b4a8ef5053</citedby><cites>FETCH-LOGICAL-c4030-9c2a3e3c991e6ac45ec3105c0e5585b921ce4a2712edf1582fca989b4a8ef5053</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1440-1681.2002.03700.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1440-1681.2002.03700.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,1417,23930,23931,25140,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12060108$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Neild, TO</creatorcontrib><creatorcontrib>Crane, GJ</creatorcontrib><title>Cellular Coupling And Conducted Vasomotor Responses</title><title>Clinical and Experimental Pharmacology and Physiology</title><addtitle>Clin Exp Pharmacol Physiol</addtitle><description>SUMMARY
1. The present brief review examines the concept of spreading vasodilator responses in arteriolar trees, its physiological relevance and possible mechanisms.
2. The most likely mechanisms involve spread of hyperpolarization through tissues in the vessel wall, made possible by electrical coupling between the cells. It is generally agreed that there is coupling between cells within the muscle and endothelial layers, but coupling between the two layers is not always present.
3. The passive electrical properties of arterioles can be modelled, using different techniques depending on the complexity of branching of the arteriolar tree. Comparison of experimental results with the model indicates that hyperpolarization can spread further than expected from passive properties alone, implying that spreading vasodilatation may be an active process.</description><subject>arteriole</subject><subject>Arterioles - physiology</subject><subject>cable properties</subject><subject>connexin</subject><subject>electrical coupling</subject><subject>endothelium</subject><subject>Endothelium, Vascular - physiology</subject><subject>gap junction</subject><subject>Humans</subject><subject>Membrane Potentials - physiology</subject><subject>Muscle, Smooth, Vascular - physiology</subject><subject>smooth muscle</subject><subject>vasodilatation</subject><subject>vasodilation</subject><subject>Vasodilation - physiology</subject><issn>0305-1870</issn><issn>1440-1681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1PwzAMhiMEYmPwF1BP3FqcpGnaA4dRjQ1pggkBO0ZZ6qKOftGsYvv3tGwaV05x5PexrYcQh4JHwQ9u1x71fXBpEFKPATAPuATwtidkeGyckiFwEC4NJQzIhbVrABAQ8HMyoAwCoBAOCY8xz9tcN05ctXWelR_OuEy6T5m0ZoOJ865tVVSbqnFe0NZVadFekrNU5xavDu-IvD1MXuOZO3-ePsbjuWv8brMbGaY5chNFFANtfIGGUxAGUIhQrCJGDfqaScowSakIWWp0FEYrX4eYChB8RG72c-um-mrRblSRWdPdq0usWqsklZFkAeuC4T5omsraBlNVN1mhm52ioHphaq16L6r3onph6leY2nbo9WFHuyow-QMPhrrA3T7wneW4-_dgFU8WfdXx7p7P7Aa3R143nyqQXAq1fJoqeb-c3y9mXEX8B_qYh0A</recordid><startdate>200207</startdate><enddate>200207</enddate><creator>Neild, TO</creator><creator>Crane, GJ</creator><general>Blackwell Science Pty</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200207</creationdate><title>Cellular Coupling And Conducted Vasomotor Responses</title><author>Neild, TO ; Crane, GJ</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4030-9c2a3e3c991e6ac45ec3105c0e5585b921ce4a2712edf1582fca989b4a8ef5053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>arteriole</topic><topic>Arterioles - physiology</topic><topic>cable properties</topic><topic>connexin</topic><topic>electrical coupling</topic><topic>endothelium</topic><topic>Endothelium, Vascular - physiology</topic><topic>gap junction</topic><topic>Humans</topic><topic>Membrane Potentials - physiology</topic><topic>Muscle, Smooth, Vascular - physiology</topic><topic>smooth muscle</topic><topic>vasodilatation</topic><topic>vasodilation</topic><topic>Vasodilation - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Neild, TO</creatorcontrib><creatorcontrib>Crane, GJ</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and Experimental Pharmacology and Physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Neild, TO</au><au>Crane, GJ</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cellular Coupling And Conducted Vasomotor Responses</atitle><jtitle>Clinical and Experimental Pharmacology and Physiology</jtitle><addtitle>Clin Exp Pharmacol Physiol</addtitle><date>2002-07</date><risdate>2002</risdate><volume>29</volume><issue>7</issue><spage>626</spage><epage>629</epage><pages>626-629</pages><issn>0305-1870</issn><eissn>1440-1681</eissn><abstract>SUMMARY
1. The present brief review examines the concept of spreading vasodilator responses in arteriolar trees, its physiological relevance and possible mechanisms.
2. The most likely mechanisms involve spread of hyperpolarization through tissues in the vessel wall, made possible by electrical coupling between the cells. It is generally agreed that there is coupling between cells within the muscle and endothelial layers, but coupling between the two layers is not always present.
3. The passive electrical properties of arterioles can be modelled, using different techniques depending on the complexity of branching of the arteriolar tree. Comparison of experimental results with the model indicates that hyperpolarization can spread further than expected from passive properties alone, implying that spreading vasodilatation may be an active process.</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Science Pty</pub><pmid>12060108</pmid><doi>10.1046/j.1440-1681.2002.03700.x</doi><tpages>4</tpages></addata></record> |
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| ispartof | Clinical and Experimental Pharmacology and Physiology, 2002-07, Vol.29 (7), p.626-629 |
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| language | eng |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | arteriole Arterioles - physiology cable properties connexin electrical coupling endothelium Endothelium, Vascular - physiology gap junction Humans Membrane Potentials - physiology Muscle, Smooth, Vascular - physiology smooth muscle vasodilatation vasodilation Vasodilation - physiology |
| title | Cellular Coupling And Conducted Vasomotor Responses |
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