Major histocompatibility gene therapy: the importance of haplotype and beta 2-microglobulin

Alloantigen gene therapy with the genes for the Class I major histocompatibility complex (MHC) HLA-B7 and beta 2-microglobulin in HLA-B7-negative patients has potential efficacy in the treatment of head and neck cancer, although the mechanism of response is unclear. Whether tumor regression is due t...

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Veröffentlicht in:	The Laryngoscope 2004-04, Vol.114 (4), p.612-615
Hauptverfasser:	Salamone, Frank N, Gleich, Lyon L, Li, Ya-Qin, Stambrook, Peter J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta 2-Microglobulin - genetics Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - therapy Cell Line, Tumor Disease Models, Animal DNA-Binding Proteins Evaluation Studies as Topic Genes, MHC Class I - genetics Genetic Therapy - methods Head and Neck Neoplasms - genetics Head and Neck Neoplasms - pathology Head and Neck Neoplasms - therapy HLA-B7 Antigen - genetics Isoantigens - therapeutic use Mice Mice, Inbred C3H Neoplasm Transplantation Prospective Studies Transfection
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