Conversion of gastric mucosa to intestinal metaplasia in Cdx2-expressing transgenic mice

Gastric intestinal metaplasia occurs as a pathological condition in the gastric mucosa. To clarify how an intestine-specific homeobox gene, Cdx2, affects the morphogenesis of gastric mucosa, we generated transgenic mice expressing Cdx2 in parietal cells. Until Day 18 after birth, the number of parie...

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Veröffentlicht in:	Biochemical and biophysical research communications 2002-06, Vol.294 (2), p.470-479
Hauptverfasser:	Mutoh, Hiroyuki, Hakamata, Yoji, Sato, Kiichi, Eda, Akashi, Yanaka, Ichiro, Honda, Sayaka, Osawa, Hiroyuki, Kaneko, Yoshinari, Sugano, Kentaro
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Animals Cdx2 CDX2 Transcription Factor Cell Differentiation Cell Division Disease Models, Animal Disease Progression Gastric Mucosa - metabolism Gastric Mucosa - pathology H(+)-K(+)-Exchanging ATPase - genetics Homeodomain Proteins - biosynthesis Homeodomain Proteins - genetics Intestinal metaplasia Intestinal Mucosa - pathology Metaplasia - pathology Mice Mice, Inbred C57BL Mice, Transgenic Parietal Cells, Gastric - metabolism Parietal Cells, Gastric - pathology Promoter Regions, Genetic - genetics Trans-Activators Transcription factor Transgenic mouse
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