The expression of murine double minute 2 is a favorable prognostic marker in esophageal squamous cell carcinoma without p53 protein accumulation
Murine double minute 2 (MDM2) is an oncoprotein that inhibits the function of p53 tumor-suppressor protein. Although there have been a few reports on MDM2 gene abnormalities, there has been no investigation into expression of the product of this gene in esophageal squamous cell carcinoma. Thus, the...
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| Veröffentlicht in: | Annals of surgical oncology 2002-06, Vol.9 (5), p.450-456 |
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| creator | Saito, Hiroaki Tsujitani, Shunichi Oka, Shinichi Ikeguchi, Masahide Maeta, Michio Kaibara, Nobuaki |
| description | Murine double minute 2 (MDM2) is an oncoprotein that inhibits the function of p53 tumor-suppressor protein. Although there have been a few reports on MDM2 gene abnormalities, there has been no investigation into expression of the product of this gene in esophageal squamous cell carcinoma. Thus, the clinicopathological and prognostic significance of the product of the MDM2 gene is as yet unknown.
MDM2 protein expression status was analyzed in surgically resected materials by immunohistochemical procedures.
The expression of MDM2 significantly correlated inversely with tumor size, depth of invasion, lymph node metastasis, lymphatic vessel invasion, and stage of disease. However, the expression of MDM2 correlated with neither p53 protein accumulation status nor Ki-67 labeling index. The prognosis with MDM2-positive status was significantly better than that with MDM2-negative status for patients with p53-negative tumors, but not in those with p53-positive tumors. Moreover, multivariate analysis showed that the expression of MDM2 was an independent prognostic factor in patients with p53-negative tumors.
These findings indicate that MDM2 immunohistochemical analysis may provide useful information concerning the prognosis in esophageal squamous cell carcinoma patients with p53-negative tumors. |
| doi_str_mv | 10.1007/bf02557267 |
| format | Article |
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MDM2 protein expression status was analyzed in surgically resected materials by immunohistochemical procedures.
The expression of MDM2 significantly correlated inversely with tumor size, depth of invasion, lymph node metastasis, lymphatic vessel invasion, and stage of disease. However, the expression of MDM2 correlated with neither p53 protein accumulation status nor Ki-67 labeling index. The prognosis with MDM2-positive status was significantly better than that with MDM2-negative status for patients with p53-negative tumors, but not in those with p53-positive tumors. Moreover, multivariate analysis showed that the expression of MDM2 was an independent prognostic factor in patients with p53-negative tumors.
These findings indicate that MDM2 immunohistochemical analysis may provide useful information concerning the prognosis in esophageal squamous cell carcinoma patients with p53-negative tumors.</description><identifier>ISSN: 1068-9265</identifier><identifier>EISSN: 1534-4681</identifier><identifier>DOI: 10.1007/bf02557267</identifier><identifier>PMID: 12052755</identifier><language>eng</language><publisher>United States: Springer Nature B.V</publisher><subject>Aged ; Aged, 80 and over ; Biomarkers, Tumor - analysis ; Carcinoma, Squamous Cell - genetics ; Carcinoma, Squamous Cell - pathology ; Esophageal Neoplasms - genetics ; Esophageal Neoplasms - pathology ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Neoplasm Metastasis ; Neoplasm Staging ; Nuclear Proteins ; Prognosis ; Proto-Oncogene Proteins - biosynthesis ; Proto-Oncogene Proteins c-mdm2 ; Tumor Suppressor Protein p53</subject><ispartof>Annals of surgical oncology, 2002-06, Vol.9 (5), p.450-456</ispartof><rights>The Society of Surgical Oncology 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c339t-5be7f07a0d387fcf71b24af1cf61dca2432fb11068ef0d179dbce7d12e74bb2c3</citedby><cites>FETCH-LOGICAL-c339t-5be7f07a0d387fcf71b24af1cf61dca2432fb11068ef0d179dbce7d12e74bb2c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12052755$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saito, Hiroaki</creatorcontrib><creatorcontrib>Tsujitani, Shunichi</creatorcontrib><creatorcontrib>Oka, Shinichi</creatorcontrib><creatorcontrib>Ikeguchi, Masahide</creatorcontrib><creatorcontrib>Maeta, Michio</creatorcontrib><creatorcontrib>Kaibara, Nobuaki</creatorcontrib><title>The expression of murine double minute 2 is a favorable prognostic marker in esophageal squamous cell carcinoma without p53 protein accumulation</title><title>Annals of surgical oncology</title><addtitle>Ann Surg Oncol</addtitle><description>Murine double minute 2 (MDM2) is an oncoprotein that inhibits the function of p53 tumor-suppressor protein. Although there have been a few reports on MDM2 gene abnormalities, there has been no investigation into expression of the product of this gene in esophageal squamous cell carcinoma. Thus, the clinicopathological and prognostic significance of the product of the MDM2 gene is as yet unknown.
MDM2 protein expression status was analyzed in surgically resected materials by immunohistochemical procedures.
The expression of MDM2 significantly correlated inversely with tumor size, depth of invasion, lymph node metastasis, lymphatic vessel invasion, and stage of disease. However, the expression of MDM2 correlated with neither p53 protein accumulation status nor Ki-67 labeling index. The prognosis with MDM2-positive status was significantly better than that with MDM2-negative status for patients with p53-negative tumors, but not in those with p53-positive tumors. Moreover, multivariate analysis showed that the expression of MDM2 was an independent prognostic factor in patients with p53-negative tumors.
These findings indicate that MDM2 immunohistochemical analysis may provide useful information concerning the prognosis in esophageal squamous cell carcinoma patients with p53-negative tumors.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Carcinoma, Squamous Cell - genetics</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Esophageal Neoplasms - genetics</subject><subject>Esophageal Neoplasms - pathology</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Metastasis</subject><subject>Neoplasm Staging</subject><subject>Nuclear Proteins</subject><subject>Prognosis</subject><subject>Proto-Oncogene Proteins - biosynthesis</subject><subject>Proto-Oncogene Proteins c-mdm2</subject><subject>Tumor Suppressor Protein p53</subject><issn>1068-9265</issn><issn>1534-4681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkc1u1TAQhS0EoqWw6QOgEQsWSAH_xPa9y7aiLVIlNmUd2c64120Sp3YM9C14ZBz1VkjdsJrR6JujM3MIOWb0M6NUf7Gecik1V_oFOWRStE2rNuxl7anaNFuu5AF5k_MtpUwLKl-TA8ap5FrKQ_LneoeAv-eEOYc4QfQwlhQmhD4WOyCMYSoLAoeQwYA3P2My63xO8WaKeQkORpPuMEGYAHOcd-YGzQD5vpgxlgwOhwGcSS5McTTwKyy7WBaYpVg1FqxrxrkylsEs1cFb8sqbIeO7fT0iP86_Xp9dNlffL76dnVw1Tojt0kiL2lNtaC822juvmeWt8cx5xXpneCu4t2x9AHraM73trUPdM466tZY7cUQ-PupWE_cF89KNIa9ezYTVdqfrjqJM_RfkjAq1payCH56Bt7GkqR7Rca6F3AjVVujTI-RSzDmh7-YU6gMfOka7Nc3u9PwpzQq_3ysWO2L_D93HJ_4Cm5eclQ</recordid><startdate>200206</startdate><enddate>200206</enddate><creator>Saito, Hiroaki</creator><creator>Tsujitani, Shunichi</creator><creator>Oka, Shinichi</creator><creator>Ikeguchi, Masahide</creator><creator>Maeta, Michio</creator><creator>Kaibara, Nobuaki</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>200206</creationdate><title>The expression of murine double minute 2 is a favorable prognostic marker in esophageal squamous cell carcinoma without p53 protein accumulation</title><author>Saito, Hiroaki ; Tsujitani, Shunichi ; Oka, Shinichi ; Ikeguchi, Masahide ; Maeta, Michio ; Kaibara, Nobuaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c339t-5be7f07a0d387fcf71b24af1cf61dca2432fb11068ef0d179dbce7d12e74bb2c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Carcinoma, Squamous Cell - genetics</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Esophageal Neoplasms - genetics</topic><topic>Esophageal Neoplasms - pathology</topic><topic>Female</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Metastasis</topic><topic>Neoplasm Staging</topic><topic>Nuclear Proteins</topic><topic>Prognosis</topic><topic>Proto-Oncogene Proteins - biosynthesis</topic><topic>Proto-Oncogene Proteins c-mdm2</topic><topic>Tumor Suppressor Protein p53</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saito, Hiroaki</creatorcontrib><creatorcontrib>Tsujitani, Shunichi</creatorcontrib><creatorcontrib>Oka, Shinichi</creatorcontrib><creatorcontrib>Ikeguchi, Masahide</creatorcontrib><creatorcontrib>Maeta, Michio</creatorcontrib><creatorcontrib>Kaibara, Nobuaki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saito, Hiroaki</au><au>Tsujitani, Shunichi</au><au>Oka, Shinichi</au><au>Ikeguchi, Masahide</au><au>Maeta, Michio</au><au>Kaibara, Nobuaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The expression of murine double minute 2 is a favorable prognostic marker in esophageal squamous cell carcinoma without p53 protein accumulation</atitle><jtitle>Annals of surgical oncology</jtitle><addtitle>Ann Surg Oncol</addtitle><date>2002-06</date><risdate>2002</risdate><volume>9</volume><issue>5</issue><spage>450</spage><epage>456</epage><pages>450-456</pages><issn>1068-9265</issn><eissn>1534-4681</eissn><abstract>Murine double minute 2 (MDM2) is an oncoprotein that inhibits the function of p53 tumor-suppressor protein. Although there have been a few reports on MDM2 gene abnormalities, there has been no investigation into expression of the product of this gene in esophageal squamous cell carcinoma. Thus, the clinicopathological and prognostic significance of the product of the MDM2 gene is as yet unknown.
MDM2 protein expression status was analyzed in surgically resected materials by immunohistochemical procedures.
The expression of MDM2 significantly correlated inversely with tumor size, depth of invasion, lymph node metastasis, lymphatic vessel invasion, and stage of disease. However, the expression of MDM2 correlated with neither p53 protein accumulation status nor Ki-67 labeling index. The prognosis with MDM2-positive status was significantly better than that with MDM2-negative status for patients with p53-negative tumors, but not in those with p53-positive tumors. Moreover, multivariate analysis showed that the expression of MDM2 was an independent prognostic factor in patients with p53-negative tumors.
These findings indicate that MDM2 immunohistochemical analysis may provide useful information concerning the prognosis in esophageal squamous cell carcinoma patients with p53-negative tumors.</abstract><cop>United States</cop><pub>Springer Nature B.V</pub><pmid>12052755</pmid><doi>10.1007/bf02557267</doi><tpages>7</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over Biomarkers, Tumor - analysis Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology Esophageal Neoplasms - genetics Esophageal Neoplasms - pathology Female Gene Expression Regulation, Neoplastic Humans Immunohistochemistry Male Middle Aged Neoplasm Metastasis Neoplasm Staging Nuclear Proteins Prognosis Proto-Oncogene Proteins - biosynthesis Proto-Oncogene Proteins c-mdm2 Tumor Suppressor Protein p53 |
| title | The expression of murine double minute 2 is a favorable prognostic marker in esophageal squamous cell carcinoma without p53 protein accumulation |
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