Enzymatic Behavior by Intercalating Molecules in a Template-Directed Ligation Reaction
Molecular midwifery: A nucleic acid intercalating molecule, proflavine (represented by blue lines), increases the coupling rate of short oligonucleotides in a template‐directed synthesis by three orders of magnitude. Several proflavine molecules act cooperatively to function as a concentration‐depen...
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| Veröffentlicht in: | Angewandte Chemie International Edition 2004-04, Vol.43 (15), p.2004-2008 |
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| container_end_page | 2008 |
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| container_issue | 15 |
| container_start_page | 2004 |
| container_title | Angewandte Chemie International Edition |
| container_volume | 43 |
| creator | Jain, Swapan S. Anet, Frank A. L. Stahle, Christopher J. Hud, Nicholas V. |
| description | Molecular midwifery: A nucleic acid intercalating molecule, proflavine (represented by blue lines), increases the coupling rate of short oligonucleotides in a template‐directed synthesis by three orders of magnitude. Several proflavine molecules act cooperatively to function as a concentration‐dependent multimolecular “enzyme”. |
| doi_str_mv | 10.1002/anie.200353155 |
| format | Article |
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| ispartof | Angewandte Chemie International Edition, 2004-04, Vol.43 (15), p.2004-2008 |
| issn | 1433-7851 1521-3773 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71795431 |
| source | MEDLINE; Wiley Online Library All Journals |
| subjects | chemical ligation DNA - biosynthesis DNA - genetics Intercalating Agents - chemistry Intercalating Agents - metabolism intercalations Models, Molecular Molecular Structure nucleic acids Proflavine - chemistry Proflavine - metabolism self-replication template synthesis Templates, Genetic |
| title | Enzymatic Behavior by Intercalating Molecules in a Template-Directed Ligation Reaction |
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