Second-trimester genetic sonography in patients with advanced maternal age and normal triple screen
OBJECTIVE: To estimate the value of second-trimester genetic sonography in detecting fetal Down syndrome in patients with advanced maternal age (at least 35 years) and normal triple screen. METHODS: Since July 1999, a prospective collection and recording of all individual triple screen risks for fet...
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| Veröffentlicht in: | Obstetrics and gynecology (New York. 1953) 2002-06, Vol.99 (6), p.993-995 |
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| container_title | Obstetrics and gynecology (New York. 1953) |
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| creator | Vintzileos, Anthony M Guzman, Edwin R Smulian, John C Yeo, Lami Scorza, William E Knuppel, Robert A |
| description | OBJECTIVE:
To estimate the value of second-trimester genetic sonography in detecting fetal Down syndrome in patients with advanced maternal age (at least 35 years) and normal triple screen.
METHODS:
Since July 1999, a prospective collection and recording of all individual triple screen risks for fetal Down syndrome was initiated for all patients with advanced maternal age presenting in our ultrasound unit for second-trimester genetic sonography. Genetic sonography evaluated the presence or absence of multiple aneuploidy markers. Outcome information included the results of genetic amniocentesis, if performed, and the results of pediatric assessment and follow-up after birth.
RESULTS:
By June 2001, 959 patients with advanced maternal age and normal triple screen were identified. Outcome information was obtained in 768 patients. The median risk for fetal Down syndrome based on maternal age was 1:213 (range 1:37–1:274). The median risk for fetal Down syndrome based on triple screen results was 1:1069 (range 1:275–1:40,000). A total of 673 patients had normal genetic sonography, and none (0%) had Down syndrome; 95 had one or more aneuploidy markers present, and four (4.2%) had fetuses with Down syndrome. The triple screen risks for these four fetuses ranged from 1:319 to 1:833.
CONCLUSION:
This study suggests that patients with advanced maternal age and normal genetic sonography carried very little risk for Down syndrome. The use of genetic sonography may increase the detection rate of fetal Down syndrome in this group of pregnant women. |
| doi_str_mv | 10.1016/S0029-7844(02)02004-5 |
| format | Article |
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To estimate the value of second-trimester genetic sonography in detecting fetal Down syndrome in patients with advanced maternal age (at least 35 years) and normal triple screen.
METHODS:
Since July 1999, a prospective collection and recording of all individual triple screen risks for fetal Down syndrome was initiated for all patients with advanced maternal age presenting in our ultrasound unit for second-trimester genetic sonography. Genetic sonography evaluated the presence or absence of multiple aneuploidy markers. Outcome information included the results of genetic amniocentesis, if performed, and the results of pediatric assessment and follow-up after birth.
RESULTS:
By June 2001, 959 patients with advanced maternal age and normal triple screen were identified. Outcome information was obtained in 768 patients. The median risk for fetal Down syndrome based on maternal age was 1:213 (range 1:37–1:274). The median risk for fetal Down syndrome based on triple screen results was 1:1069 (range 1:275–1:40,000). A total of 673 patients had normal genetic sonography, and none (0%) had Down syndrome; 95 had one or more aneuploidy markers present, and four (4.2%) had fetuses with Down syndrome. The triple screen risks for these four fetuses ranged from 1:319 to 1:833.
CONCLUSION:
This study suggests that patients with advanced maternal age and normal genetic sonography carried very little risk for Down syndrome. The use of genetic sonography may increase the detection rate of fetal Down syndrome in this group of pregnant women.</description><identifier>ISSN: 0029-7844</identifier><identifier>EISSN: 1873-233X</identifier><identifier>DOI: 10.1016/S0029-7844(02)02004-5</identifier><identifier>PMID: 12052588</identifier><identifier>CODEN: OBGNAS</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Biological and medical sciences ; Down Syndrome - diagnostic imaging ; Female ; Genetic Testing - methods ; Gynecology. Andrology. Obstetrics ; Humans ; Management. Prenatal diagnosis ; Maternal Age ; Medical sciences ; Middle Aged ; New Jersey ; Outcome Assessment (Health Care) ; Predictive Value of Tests ; Pregnancy ; Pregnancy Trimester, Second ; Pregnancy, High-Risk ; Pregnancy. Fetus. Placenta ; Prospective Studies ; Ultrasonography, Prenatal - standards</subject><ispartof>Obstetrics and gynecology (New York. 1953), 2002-06, Vol.99 (6), p.993-995</ispartof><rights>2002 The American College of Obstetricians and Gynecologists</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-e1880632a2c778538df66245560bba9625e669ef296ccd0aa4f9c98f5be4e46b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13705480$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12052588$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vintzileos, Anthony M</creatorcontrib><creatorcontrib>Guzman, Edwin R</creatorcontrib><creatorcontrib>Smulian, John C</creatorcontrib><creatorcontrib>Yeo, Lami</creatorcontrib><creatorcontrib>Scorza, William E</creatorcontrib><creatorcontrib>Knuppel, Robert A</creatorcontrib><title>Second-trimester genetic sonography in patients with advanced maternal age and normal triple screen</title><title>Obstetrics and gynecology (New York. 1953)</title><addtitle>Obstet Gynecol</addtitle><description>OBJECTIVE:
To estimate the value of second-trimester genetic sonography in detecting fetal Down syndrome in patients with advanced maternal age (at least 35 years) and normal triple screen.
METHODS:
Since July 1999, a prospective collection and recording of all individual triple screen risks for fetal Down syndrome was initiated for all patients with advanced maternal age presenting in our ultrasound unit for second-trimester genetic sonography. Genetic sonography evaluated the presence or absence of multiple aneuploidy markers. Outcome information included the results of genetic amniocentesis, if performed, and the results of pediatric assessment and follow-up after birth.
RESULTS:
By June 2001, 959 patients with advanced maternal age and normal triple screen were identified. Outcome information was obtained in 768 patients. The median risk for fetal Down syndrome based on maternal age was 1:213 (range 1:37–1:274). The median risk for fetal Down syndrome based on triple screen results was 1:1069 (range 1:275–1:40,000). A total of 673 patients had normal genetic sonography, and none (0%) had Down syndrome; 95 had one or more aneuploidy markers present, and four (4.2%) had fetuses with Down syndrome. The triple screen risks for these four fetuses ranged from 1:319 to 1:833.
CONCLUSION:
This study suggests that patients with advanced maternal age and normal genetic sonography carried very little risk for Down syndrome. The use of genetic sonography may increase the detection rate of fetal Down syndrome in this group of pregnant women.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Down Syndrome - diagnostic imaging</subject><subject>Female</subject><subject>Genetic Testing - methods</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Management. Prenatal diagnosis</subject><subject>Maternal Age</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>New Jersey</subject><subject>Outcome Assessment (Health Care)</subject><subject>Predictive Value of Tests</subject><subject>Pregnancy</subject><subject>Pregnancy Trimester, Second</subject><subject>Pregnancy, High-Risk</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Prospective Studies</subject><subject>Ultrasonography, Prenatal - standards</subject><issn>0029-7844</issn><issn>1873-233X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1P3DAQhi3UCpaPn0DlS6v2EBjbsWOfEEKlrYTEASr1ZjnOZHGVOKmdpeLfY9hVOfY0Gul55-Mh5JTBGQOmzu8AuKkaXdefgX8BDlBXco-smG5ExYX49Y6s_iEH5DDn3wAlaMQ-OWAcJJdar4i_Qz_FrlpSGDEvmOgaIy7B0zzFaZ3c_PBEQ6SzWwLGJdO_YXmgrnt00WNHR1ci0Q3UrZG62NE4pbG0Zdw8IM0-IcZj8r53Q8aTXT0iP6-_3l99r25uv_24urypvDBsqZBpDUpwx33TaCl01yvFaykVtK0ziktUymDPjfK-A-fq3nije9lijbVqxRH5tJ07p-nPpnxjx5A9DoOLOG2ybVhjpJBNAeUW9GnKOWFv5_K-S0-WgX2xa1_t2hd1Frh9tWtlyX3YLdi0I3ZvqZ3OAnzcAS57N_SpWAr5jRMNyFpD4S62HBYdjwGTzb7oLUZDQr_Ybgr_OeUZKmqXsw</recordid><startdate>20020601</startdate><enddate>20020601</enddate><creator>Vintzileos, Anthony M</creator><creator>Guzman, Edwin R</creator><creator>Smulian, John C</creator><creator>Yeo, Lami</creator><creator>Scorza, William E</creator><creator>Knuppel, Robert A</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020601</creationdate><title>Second-trimester genetic sonography in patients with advanced maternal age and normal triple screen</title><author>Vintzileos, Anthony M ; Guzman, Edwin R ; Smulian, John C ; Yeo, Lami ; Scorza, William E ; Knuppel, Robert A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-e1880632a2c778538df66245560bba9625e669ef296ccd0aa4f9c98f5be4e46b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Down Syndrome - diagnostic imaging</topic><topic>Female</topic><topic>Genetic Testing - methods</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Management. Prenatal diagnosis</topic><topic>Maternal Age</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>New Jersey</topic><topic>Outcome Assessment (Health Care)</topic><topic>Predictive Value of Tests</topic><topic>Pregnancy</topic><topic>Pregnancy Trimester, Second</topic><topic>Pregnancy, High-Risk</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Prospective Studies</topic><topic>Ultrasonography, Prenatal - standards</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vintzileos, Anthony M</creatorcontrib><creatorcontrib>Guzman, Edwin R</creatorcontrib><creatorcontrib>Smulian, John C</creatorcontrib><creatorcontrib>Yeo, Lami</creatorcontrib><creatorcontrib>Scorza, William E</creatorcontrib><creatorcontrib>Knuppel, Robert A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vintzileos, Anthony M</au><au>Guzman, Edwin R</au><au>Smulian, John C</au><au>Yeo, Lami</au><au>Scorza, William E</au><au>Knuppel, Robert A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Second-trimester genetic sonography in patients with advanced maternal age and normal triple screen</atitle><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle><addtitle>Obstet Gynecol</addtitle><date>2002-06-01</date><risdate>2002</risdate><volume>99</volume><issue>6</issue><spage>993</spage><epage>995</epage><pages>993-995</pages><issn>0029-7844</issn><eissn>1873-233X</eissn><coden>OBGNAS</coden><abstract>OBJECTIVE:
To estimate the value of second-trimester genetic sonography in detecting fetal Down syndrome in patients with advanced maternal age (at least 35 years) and normal triple screen.
METHODS:
Since July 1999, a prospective collection and recording of all individual triple screen risks for fetal Down syndrome was initiated for all patients with advanced maternal age presenting in our ultrasound unit for second-trimester genetic sonography. Genetic sonography evaluated the presence or absence of multiple aneuploidy markers. Outcome information included the results of genetic amniocentesis, if performed, and the results of pediatric assessment and follow-up after birth.
RESULTS:
By June 2001, 959 patients with advanced maternal age and normal triple screen were identified. Outcome information was obtained in 768 patients. The median risk for fetal Down syndrome based on maternal age was 1:213 (range 1:37–1:274). The median risk for fetal Down syndrome based on triple screen results was 1:1069 (range 1:275–1:40,000). A total of 673 patients had normal genetic sonography, and none (0%) had Down syndrome; 95 had one or more aneuploidy markers present, and four (4.2%) had fetuses with Down syndrome. The triple screen risks for these four fetuses ranged from 1:319 to 1:833.
CONCLUSION:
This study suggests that patients with advanced maternal age and normal genetic sonography carried very little risk for Down syndrome. The use of genetic sonography may increase the detection rate of fetal Down syndrome in this group of pregnant women.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>12052588</pmid><doi>10.1016/S0029-7844(02)02004-5</doi><tpages>3</tpages></addata></record> |
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| ispartof | Obstetrics and gynecology (New York. 1953), 2002-06, Vol.99 (6), p.993-995 |
| issn | 0029-7844 1873-233X |
| language | eng |
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| source | MEDLINE; Journals@Ovid Ovid Autoload |
| subjects | Adult Biological and medical sciences Down Syndrome - diagnostic imaging Female Genetic Testing - methods Gynecology. Andrology. Obstetrics Humans Management. Prenatal diagnosis Maternal Age Medical sciences Middle Aged New Jersey Outcome Assessment (Health Care) Predictive Value of Tests Pregnancy Pregnancy Trimester, Second Pregnancy, High-Risk Pregnancy. Fetus. Placenta Prospective Studies Ultrasonography, Prenatal - standards |
| title | Second-trimester genetic sonography in patients with advanced maternal age and normal triple screen |
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