Survival of a 75% burn in a patient with longstanding Addison’s disease
This is the first reported case of survival of a significant burn in a patient with established Addison’s disease. The systemic stress response to thermal injury is well recognised, there is a marked hypermetabolic response with prolonged periods of catabolism. In particular, the elevation of plasma...
Gespeichert in:
| Veröffentlicht in: | Burns 2002-06, Vol.28 (4), p.391-393 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 393 |
|---|---|
| container_issue | 4 |
| container_start_page | 391 |
| container_title | Burns |
| container_volume | 28 |
| creator | James, S.E. Ghosh, S.J. Montgomerie, J. Philp, B.M. Dziewulski, P. |
| description | This is the first reported case of survival of a significant burn in a patient with established Addison’s disease. The systemic stress response to thermal injury is well recognised, there is a marked hypermetabolic response with prolonged periods of catabolism. In particular, the elevation of plasma cortisol levels is crucial for this response to severe systemic stress. Cortisol elevation is maintained for the duration of burn wound healing, is proportional to the burned body surface area and the normal circadian rhythm of endogenous cortisol is lost. Acute adrenal insufficiency has been described in patients suffering major burn injuries with generally poor outcomes. We discuss the management and complications of adrenal replacement therapy in a severe burn setting, as illustrated by this case report. |
| doi_str_mv | 10.1016/S0305-4179(02)00014-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71794678</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0305417902000141</els_id><sourcerecordid>71794678</sourcerecordid><originalsourceid>FETCH-LOGICAL-c391t-83d915d73b098e421019be261e68f35083da5bee69c65b2c4303a93799faab673</originalsourceid><addsrcrecordid>eNqFkMFO3DAQhi1UBAvlEVr5AoJD6NiO4_iEEAKKhMQBOFuOM6Guss7WThZx4zX6ejwJhl3BkdN45G88_j9CfjA4ZsCqX7cgQBYlU_oQ-BEAsLJgG2TGaqULVoL-RmYfyDbZSelvhkDWsEW2GQfJRQ0zcnU7xaVf2p4OHbVUyX3aTDFQH3K3sKPHMNJHP_6h_RAe0mhD68MDPW1bn4bw8vw_0XxCm_A72exsn3BvXXfJ_cX53dnv4vrm8urs9LpwQrOxqEWrmWyVaEDXWPIcRjfIK4ZV3QkJ-d7KBrHSrpINd6UAYbVQWnfWNpUSu-Rg9e4iDv8mTKOZ--Sw723AYUpG5bxlpeoMyhXo4pBSxM4sop_b-GQYmDeH5t2heRNkgJt3h4bluZ_rBVMzx_Zzai0tA_trwCZn-y7a4Hz65ITiZcV15k5WHGYdS4_RJJd9Omx9RDeadvBffOUVS-SMgw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71794678</pqid></control><display><type>article</type><title>Survival of a 75% burn in a patient with longstanding Addison’s disease</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>James, S.E. ; Ghosh, S.J. ; Montgomerie, J. ; Philp, B.M. ; Dziewulski, P.</creator><creatorcontrib>James, S.E. ; Ghosh, S.J. ; Montgomerie, J. ; Philp, B.M. ; Dziewulski, P.</creatorcontrib><description>This is the first reported case of survival of a significant burn in a patient with established Addison’s disease. The systemic stress response to thermal injury is well recognised, there is a marked hypermetabolic response with prolonged periods of catabolism. In particular, the elevation of plasma cortisol levels is crucial for this response to severe systemic stress. Cortisol elevation is maintained for the duration of burn wound healing, is proportional to the burned body surface area and the normal circadian rhythm of endogenous cortisol is lost. Acute adrenal insufficiency has been described in patients suffering major burn injuries with generally poor outcomes. We discuss the management and complications of adrenal replacement therapy in a severe burn setting, as illustrated by this case report.</description><identifier>ISSN: 0305-4179</identifier><identifier>EISSN: 1879-1409</identifier><identifier>DOI: 10.1016/S0305-4179(02)00014-1</identifier><identifier>PMID: 12052380</identifier><identifier>CODEN: BURND8</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Addison Disease - complications ; Addison’s ; Adrenal ; Adrenals. Adrenal axis. Renin-angiotensin system (diseases) ; Adult ; Biological and medical sciences ; Burn ; Burns ; Burns - mortality ; Burns - therapy ; Cortisol ; Endocrinopathies ; Humans ; Hydrocortisone - blood ; Male ; Medical sciences ; Non tumoral diseases. Target tissue resistance. Benign neoplasms ; Traumas. Diseases due to physical agents</subject><ispartof>Burns, 2002-06, Vol.28 (4), p.391-393</ispartof><rights>2002 Elsevier Science Ltd and ISBI</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-83d915d73b098e421019be261e68f35083da5bee69c65b2c4303a93799faab673</citedby><cites>FETCH-LOGICAL-c391t-83d915d73b098e421019be261e68f35083da5bee69c65b2c4303a93799faab673</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0305417902000141$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13724629$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12052380$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>James, S.E.</creatorcontrib><creatorcontrib>Ghosh, S.J.</creatorcontrib><creatorcontrib>Montgomerie, J.</creatorcontrib><creatorcontrib>Philp, B.M.</creatorcontrib><creatorcontrib>Dziewulski, P.</creatorcontrib><title>Survival of a 75% burn in a patient with longstanding Addison’s disease</title><title>Burns</title><addtitle>Burns</addtitle><description>This is the first reported case of survival of a significant burn in a patient with established Addison’s disease. The systemic stress response to thermal injury is well recognised, there is a marked hypermetabolic response with prolonged periods of catabolism. In particular, the elevation of plasma cortisol levels is crucial for this response to severe systemic stress. Cortisol elevation is maintained for the duration of burn wound healing, is proportional to the burned body surface area and the normal circadian rhythm of endogenous cortisol is lost. Acute adrenal insufficiency has been described in patients suffering major burn injuries with generally poor outcomes. We discuss the management and complications of adrenal replacement therapy in a severe burn setting, as illustrated by this case report.</description><subject>Addison Disease - complications</subject><subject>Addison’s</subject><subject>Adrenal</subject><subject>Adrenals. Adrenal axis. Renin-angiotensin system (diseases)</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Burn</subject><subject>Burns</subject><subject>Burns - mortality</subject><subject>Burns - therapy</subject><subject>Cortisol</subject><subject>Endocrinopathies</subject><subject>Humans</subject><subject>Hydrocortisone - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Non tumoral diseases. Target tissue resistance. Benign neoplasms</subject><subject>Traumas. Diseases due to physical agents</subject><issn>0305-4179</issn><issn>1879-1409</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFO3DAQhi1UBAvlEVr5AoJD6NiO4_iEEAKKhMQBOFuOM6Guss7WThZx4zX6ejwJhl3BkdN45G88_j9CfjA4ZsCqX7cgQBYlU_oQ-BEAsLJgG2TGaqULVoL-RmYfyDbZSelvhkDWsEW2GQfJRQ0zcnU7xaVf2p4OHbVUyX3aTDFQH3K3sKPHMNJHP_6h_RAe0mhD68MDPW1bn4bw8vw_0XxCm_A72exsn3BvXXfJ_cX53dnv4vrm8urs9LpwQrOxqEWrmWyVaEDXWPIcRjfIK4ZV3QkJ-d7KBrHSrpINd6UAYbVQWnfWNpUSu-Rg9e4iDv8mTKOZ--Sw723AYUpG5bxlpeoMyhXo4pBSxM4sop_b-GQYmDeH5t2heRNkgJt3h4bluZ_rBVMzx_Zzai0tA_trwCZn-y7a4Hz65ITiZcV15k5WHGYdS4_RJJd9Omx9RDeadvBffOUVS-SMgw</recordid><startdate>20020601</startdate><enddate>20020601</enddate><creator>James, S.E.</creator><creator>Ghosh, S.J.</creator><creator>Montgomerie, J.</creator><creator>Philp, B.M.</creator><creator>Dziewulski, P.</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020601</creationdate><title>Survival of a 75% burn in a patient with longstanding Addison’s disease</title><author>James, S.E. ; Ghosh, S.J. ; Montgomerie, J. ; Philp, B.M. ; Dziewulski, P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-83d915d73b098e421019be261e68f35083da5bee69c65b2c4303a93799faab673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Addison Disease - complications</topic><topic>Addison’s</topic><topic>Adrenal</topic><topic>Adrenals. Adrenal axis. Renin-angiotensin system (diseases)</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Burn</topic><topic>Burns</topic><topic>Burns - mortality</topic><topic>Burns - therapy</topic><topic>Cortisol</topic><topic>Endocrinopathies</topic><topic>Humans</topic><topic>Hydrocortisone - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Non tumoral diseases. Target tissue resistance. Benign neoplasms</topic><topic>Traumas. Diseases due to physical agents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>James, S.E.</creatorcontrib><creatorcontrib>Ghosh, S.J.</creatorcontrib><creatorcontrib>Montgomerie, J.</creatorcontrib><creatorcontrib>Philp, B.M.</creatorcontrib><creatorcontrib>Dziewulski, P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Burns</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>James, S.E.</au><au>Ghosh, S.J.</au><au>Montgomerie, J.</au><au>Philp, B.M.</au><au>Dziewulski, P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Survival of a 75% burn in a patient with longstanding Addison’s disease</atitle><jtitle>Burns</jtitle><addtitle>Burns</addtitle><date>2002-06-01</date><risdate>2002</risdate><volume>28</volume><issue>4</issue><spage>391</spage><epage>393</epage><pages>391-393</pages><issn>0305-4179</issn><eissn>1879-1409</eissn><coden>BURND8</coden><abstract>This is the first reported case of survival of a significant burn in a patient with established Addison’s disease. The systemic stress response to thermal injury is well recognised, there is a marked hypermetabolic response with prolonged periods of catabolism. In particular, the elevation of plasma cortisol levels is crucial for this response to severe systemic stress. Cortisol elevation is maintained for the duration of burn wound healing, is proportional to the burned body surface area and the normal circadian rhythm of endogenous cortisol is lost. Acute adrenal insufficiency has been described in patients suffering major burn injuries with generally poor outcomes. We discuss the management and complications of adrenal replacement therapy in a severe burn setting, as illustrated by this case report.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>12052380</pmid><doi>10.1016/S0305-4179(02)00014-1</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0305-4179 |
| ispartof | Burns, 2002-06, Vol.28 (4), p.391-393 |
| issn | 0305-4179 1879-1409 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71794678 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Addison Disease - complications Addison’s Adrenal Adrenals. Adrenal axis. Renin-angiotensin system (diseases) Adult Biological and medical sciences Burn Burns Burns - mortality Burns - therapy Cortisol Endocrinopathies Humans Hydrocortisone - blood Male Medical sciences Non tumoral diseases. Target tissue resistance. Benign neoplasms Traumas. Diseases due to physical agents |
| title | Survival of a 75% burn in a patient with longstanding Addison’s disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T21%3A57%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Survival%20of%20a%2075%25%20burn%20in%20a%20patient%20with%20longstanding%20Addison%E2%80%99s%20disease&rft.jtitle=Burns&rft.au=James,%20S.E.&rft.date=2002-06-01&rft.volume=28&rft.issue=4&rft.spage=391&rft.epage=393&rft.pages=391-393&rft.issn=0305-4179&rft.eissn=1879-1409&rft.coden=BURND8&rft_id=info:doi/10.1016/S0305-4179(02)00014-1&rft_dat=%3Cproquest_cross%3E71794678%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=71794678&rft_id=info:pmid/12052380&rft_els_id=S0305417902000141&rfr_iscdi=true |