The influence of pellet shape and surface properties on the drug release from uncoated and coated pellets

Pellets of different shape, varying from spherical to cylindrical, without and with film coating were tested for their drug release properties. For non-disintegrating uncoated pellets, drug release was found to be inversely related to the pellet porosity. A change of 5% in porosity doubled the value...

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Veröffentlicht in:	International journal of pharmaceutics 2002-06, Vol.239 (1), p.171-178
Hauptverfasser:	Chopra, Ranjana, Alderborn, Göran, Podczeck, Fridrun, Newton, J.Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Anti-Inflammatory Agents, Non-Steroidal - chemistry Biological and medical sciences Drug release Film coating General pharmacology Hydrogen-Ion Concentration Kinetics Mean dissolution time Medical sciences Models, Chemical Pellet porosity Pellet shape Pellet surface area Pharmaceutical Preparations - chemistry Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Piroxicam - chemistry Relative dispersion coefficient Solubility Solvents Sulfonamides - chemistry
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