The influence of pellet shape and surface properties on the drug release from uncoated and coated pellets
Pellets of different shape, varying from spherical to cylindrical, without and with film coating were tested for their drug release properties. For non-disintegrating uncoated pellets, drug release was found to be inversely related to the pellet porosity. A change of 5% in porosity doubled the value...
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| Veröffentlicht in: | International journal of pharmaceutics 2002-06, Vol.239 (1), p.171-178 |
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| container_title | International journal of pharmaceutics |
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| creator | Chopra, Ranjana Alderborn, Göran Podczeck, Fridrun Newton, J.Michael |
| description | Pellets of different shape, varying from spherical to cylindrical, without and with film coating were tested for their drug release properties. For non-disintegrating uncoated pellets, drug release was found to be inversely related to the pellet porosity. A change of 5% in porosity doubled the value of the mean dissolution time (MDT). As coat thickness increased, the MDT value of coated pellets increased. For those pellets, which are nearly spherical, once a thickness of about 20 μm had been achieved, there was little further reduction in retardation. Pellets produced by extrusion/spheronisation appeared to prolong drug release to a larger extent than those where the extrusion step had been omitted. There was a strong inverse relationship between the surface area by volume of the coated pellets and the value of the MDT. The values of the relative dispersion coefficient (RD), which is an indicator of the drug release mechanism, were related to the amount of fluid used to manufacture the pellets and the pellet shape, in a similar fashion for both uncoated and coated pellets. This suggested that the presence of the film coating changed the rate but not the mechanism of drug release. |
| doi_str_mv | 10.1016/S0378-5173(02)00104-7 |
| format | Article |
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For non-disintegrating uncoated pellets, drug release was found to be inversely related to the pellet porosity. A change of 5% in porosity doubled the value of the mean dissolution time (MDT). As coat thickness increased, the MDT value of coated pellets increased. For those pellets, which are nearly spherical, once a thickness of about 20 μm had been achieved, there was little further reduction in retardation. Pellets produced by extrusion/spheronisation appeared to prolong drug release to a larger extent than those where the extrusion step had been omitted. There was a strong inverse relationship between the surface area by volume of the coated pellets and the value of the MDT. The values of the relative dispersion coefficient (RD), which is an indicator of the drug release mechanism, were related to the amount of fluid used to manufacture the pellets and the pellet shape, in a similar fashion for both uncoated and coated pellets. This suggested that the presence of the film coating changed the rate but not the mechanism of drug release.</description><identifier>ISSN: 0378-5173</identifier><identifier>EISSN: 1873-3476</identifier><identifier>DOI: 10.1016/S0378-5173(02)00104-7</identifier><identifier>PMID: 12052702</identifier><identifier>CODEN: IJPHDE</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Algorithms ; Anti-Inflammatory Agents, Non-Steroidal - chemistry ; Biological and medical sciences ; Drug release ; Film coating ; General pharmacology ; Hydrogen-Ion Concentration ; Kinetics ; Mean dissolution time ; Medical sciences ; Models, Chemical ; Pellet porosity ; Pellet shape ; Pellet surface area ; Pharmaceutical Preparations - chemistry ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Piroxicam - chemistry ; Relative dispersion coefficient ; Solubility ; Solvents ; Sulfonamides - chemistry</subject><ispartof>International journal of pharmaceutics, 2002-06, Vol.239 (1), p.171-178</ispartof><rights>2002 Elsevier Science B.V.</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-20db8ac6acbc66cd305c9732aa9703d290afa12afc5a05c7391d4f508de27cee3</citedby><cites>FETCH-LOGICAL-c391t-20db8ac6acbc66cd305c9732aa9703d290afa12afc5a05c7391d4f508de27cee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0378-5173(02)00104-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13705099$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12052702$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chopra, Ranjana</creatorcontrib><creatorcontrib>Alderborn, Göran</creatorcontrib><creatorcontrib>Podczeck, Fridrun</creatorcontrib><creatorcontrib>Newton, J.Michael</creatorcontrib><title>The influence of pellet shape and surface properties on the drug release from uncoated and coated pellets</title><title>International journal of pharmaceutics</title><addtitle>Int J Pharm</addtitle><description>Pellets of different shape, varying from spherical to cylindrical, without and with film coating were tested for their drug release properties. For non-disintegrating uncoated pellets, drug release was found to be inversely related to the pellet porosity. A change of 5% in porosity doubled the value of the mean dissolution time (MDT). As coat thickness increased, the MDT value of coated pellets increased. For those pellets, which are nearly spherical, once a thickness of about 20 μm had been achieved, there was little further reduction in retardation. Pellets produced by extrusion/spheronisation appeared to prolong drug release to a larger extent than those where the extrusion step had been omitted. There was a strong inverse relationship between the surface area by volume of the coated pellets and the value of the MDT. The values of the relative dispersion coefficient (RD), which is an indicator of the drug release mechanism, were related to the amount of fluid used to manufacture the pellets and the pellet shape, in a similar fashion for both uncoated and coated pellets. This suggested that the presence of the film coating changed the rate but not the mechanism of drug release.</description><subject>Algorithms</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - chemistry</subject><subject>Biological and medical sciences</subject><subject>Drug release</subject><subject>Film coating</subject><subject>General pharmacology</subject><subject>Hydrogen-Ion Concentration</subject><subject>Kinetics</subject><subject>Mean dissolution time</subject><subject>Medical sciences</subject><subject>Models, Chemical</subject><subject>Pellet porosity</subject><subject>Pellet shape</subject><subject>Pellet surface area</subject><subject>Pharmaceutical Preparations - chemistry</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Piroxicam - chemistry</subject><subject>Relative dispersion coefficient</subject><subject>Solubility</subject><subject>Solvents</subject><subject>Sulfonamides - chemistry</subject><issn>0378-5173</issn><issn>1873-3476</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFqGzEQhkVpaNykj5CgS0N72GQkeVfeUwimbQKGHOKexVgaxSrr3Y20G8jbV7aX5tiTBPP9o59PjF0IuBYgqpsnUHpRlEKrbyC_AwiYF_oDm4mFVoWa6-ojm_1DTtnnlP4AQCWF-sROhYRSapAzFtZb4qH1zUitJd553lPT0MDTFnvi2Dqexugxz_rY9RSHQIl3LR9yzsXxmUdqCBNxH7sdH1vb4UDuEJyux4XpnJ14bBJ9mc4z9vvnj_Xyvlg9_npY3q0Kq2oxFBLcZoG2QruxVWWdgtLWWknEWoNysgb0KCR6W2Ie6Rxyc1_CwpHUlkidsavj3tz3ZaQ0mF1INnfAlroxGS10rQSoDJZH0MYupUje9DHsML4ZAWbv2Bwcm71AA9IcHBudc5fTA-NmR-49NUnNwNcJwGSx8RFbG9I7pzSUUNeZuz1ylHW8Boom2bD_Bhci2cG4Lvynyl_MdJnV</recordid><startdate>20020604</startdate><enddate>20020604</enddate><creator>Chopra, Ranjana</creator><creator>Alderborn, Göran</creator><creator>Podczeck, Fridrun</creator><creator>Newton, J.Michael</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020604</creationdate><title>The influence of pellet shape and surface properties on the drug release from uncoated and coated pellets</title><author>Chopra, Ranjana ; Alderborn, Göran ; Podczeck, Fridrun ; Newton, J.Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-20db8ac6acbc66cd305c9732aa9703d290afa12afc5a05c7391d4f508de27cee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Algorithms</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - chemistry</topic><topic>Biological and medical sciences</topic><topic>Drug release</topic><topic>Film coating</topic><topic>General pharmacology</topic><topic>Hydrogen-Ion Concentration</topic><topic>Kinetics</topic><topic>Mean dissolution time</topic><topic>Medical sciences</topic><topic>Models, Chemical</topic><topic>Pellet porosity</topic><topic>Pellet shape</topic><topic>Pellet surface area</topic><topic>Pharmaceutical Preparations - chemistry</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Piroxicam - chemistry</topic><topic>Relative dispersion coefficient</topic><topic>Solubility</topic><topic>Solvents</topic><topic>Sulfonamides - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chopra, Ranjana</creatorcontrib><creatorcontrib>Alderborn, Göran</creatorcontrib><creatorcontrib>Podczeck, Fridrun</creatorcontrib><creatorcontrib>Newton, J.Michael</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of pharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chopra, Ranjana</au><au>Alderborn, Göran</au><au>Podczeck, Fridrun</au><au>Newton, J.Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The influence of pellet shape and surface properties on the drug release from uncoated and coated pellets</atitle><jtitle>International journal of pharmaceutics</jtitle><addtitle>Int J Pharm</addtitle><date>2002-06-04</date><risdate>2002</risdate><volume>239</volume><issue>1</issue><spage>171</spage><epage>178</epage><pages>171-178</pages><issn>0378-5173</issn><eissn>1873-3476</eissn><coden>IJPHDE</coden><abstract>Pellets of different shape, varying from spherical to cylindrical, without and with film coating were tested for their drug release properties. For non-disintegrating uncoated pellets, drug release was found to be inversely related to the pellet porosity. A change of 5% in porosity doubled the value of the mean dissolution time (MDT). As coat thickness increased, the MDT value of coated pellets increased. For those pellets, which are nearly spherical, once a thickness of about 20 μm had been achieved, there was little further reduction in retardation. Pellets produced by extrusion/spheronisation appeared to prolong drug release to a larger extent than those where the extrusion step had been omitted. There was a strong inverse relationship between the surface area by volume of the coated pellets and the value of the MDT. The values of the relative dispersion coefficient (RD), which is an indicator of the drug release mechanism, were related to the amount of fluid used to manufacture the pellets and the pellet shape, in a similar fashion for both uncoated and coated pellets. This suggested that the presence of the film coating changed the rate but not the mechanism of drug release.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>12052702</pmid><doi>10.1016/S0378-5173(02)00104-7</doi><tpages>8</tpages></addata></record> |
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| ispartof | International journal of pharmaceutics, 2002-06, Vol.239 (1), p.171-178 |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Algorithms Anti-Inflammatory Agents, Non-Steroidal - chemistry Biological and medical sciences Drug release Film coating General pharmacology Hydrogen-Ion Concentration Kinetics Mean dissolution time Medical sciences Models, Chemical Pellet porosity Pellet shape Pellet surface area Pharmaceutical Preparations - chemistry Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Piroxicam - chemistry Relative dispersion coefficient Solubility Solvents Sulfonamides - chemistry |
| title | The influence of pellet shape and surface properties on the drug release from uncoated and coated pellets |
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