Utilization of supercritical carbon dioxide for complex formation of ibuprofen and methyl-β-cyclodextrin

The dissolution rate of a drug into the biological environment can be enhanced by forming complexes with cyclodextrins and their derivatives. In this study, ibuprofen–methyl-β-cyclodextrin complexes were prepared successfully by passing ibuprofen-laden CO 2 through a methyl-β-cyclodextrin packed bed...

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Veröffentlicht in:	International journal of pharmaceutics 2002-06, Vol.239 (1), p.103-112
Hauptverfasser:	Charoenchaitrakool, M., Dehghani, F., Foster, N.R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Inflammatory Agents, Non-Steroidal - chemistry beta-Cyclodextrins Biological and medical sciences Calorimetry, Differential Scanning Carbon Dioxide - chemistry Crystallography, X-Ray Cyclodextrins Drug Compounding Excipients General pharmacology Ibuprofen Ibuprofen - chemistry Kinetics Medical sciences Methyl-β-cyclodextrin Microscopy, Electron, Scanning Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Pressure Solubility Supercritical CO 2
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