Cogan Syndrome in children: Early diagnosis and treatment is critical to prognosis
To present two cases of pediatric Cogan Syndrome and to highlight the differences between the adult and pediatric forms of the disease, as well as the importance of early diagnosis and treatment. Interventional case report. Institutional setting. Corneal lesions were much more diffuse than those obs...
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| Veröffentlicht in: | American journal of ophthalmology 2004-04, Vol.137 (4), p.757-758 |
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| container_title | American journal of ophthalmology |
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| creator | ORSONI, Jelka G ZAVOTA, Laura VINCENTI, Vincenzo PELLISTRI, Isabella RAMA, Paolo |
| description | To present two cases of pediatric Cogan Syndrome and to highlight the differences between the adult and pediatric forms of the disease, as well as the importance of early diagnosis and treatment.
Interventional case report.
Institutional setting.
Corneal lesions were much more diffuse than those observed in adult Cogan syndrome. Immunosuppressive drug combination therapy successfully resolved systemic and ocular inflammation, but the involvement of the pupillary area caused permanent low vision in one case and amblyopia in the other.
When chronic ocular inflammation is observed in association with sensory neural hearing loss and any systemic signs of autoimmune inflammation, a diagnosis of Cogan syndrome should be suspected. If immunosuppressive treatment is not initiated as soon as possible, permanent low vision and deafness can result. |
| doi_str_mv | 10.1016/S0002-9394(03)01122-X |
| format | Article |
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Interventional case report.
Institutional setting.
Corneal lesions were much more diffuse than those observed in adult Cogan syndrome. Immunosuppressive drug combination therapy successfully resolved systemic and ocular inflammation, but the involvement of the pupillary area caused permanent low vision in one case and amblyopia in the other.
When chronic ocular inflammation is observed in association with sensory neural hearing loss and any systemic signs of autoimmune inflammation, a diagnosis of Cogan syndrome should be suspected. If immunosuppressive treatment is not initiated as soon as possible, permanent low vision and deafness can result.</description><identifier>ISSN: 0002-9394</identifier><identifier>EISSN: 1879-1891</identifier><identifier>DOI: 10.1016/S0002-9394(03)01122-X</identifier><identifier>PMID: 15059721</identifier><identifier>CODEN: AJOPAA</identifier><language>eng</language><publisher>New York, NY: Elsevier</publisher><subject>Amblyopia - etiology ; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use ; Aspirin - therapeutic use ; Autoimmune Diseases - complications ; Autoimmune Diseases - diagnosis ; Autoimmune Diseases - drug therapy ; Biological and medical sciences ; Child ; Child, Preschool ; Cyclosporine - therapeutic use ; Diseases of cornea, anterior segment and sclera ; Drug Therapy, Combination ; Fludrocortisone - therapeutic use ; Hearing Loss, Sensorineural - complications ; Hearing Loss, Sensorineural - diagnosis ; Hearing Loss, Sensorineural - drug therapy ; Humans ; Immunosuppressive Agents - therapeutic use ; Keratitis - complications ; Keratitis - diagnosis ; Keratitis - drug therapy ; Male ; Medical sciences ; Methotrexate - therapeutic use ; Ophthalmology ; Prognosis ; Syndrome ; Vasculitis - complications ; Vasculitis - diagnosis ; Vasculitis - drug therapy ; Vision, Low - etiology</subject><ispartof>American journal of ophthalmology, 2004-04, Vol.137 (4), p.757-758</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c335t-b6c37163a7dd1a1ddad83c90f010f88fabc59d37ba59427b362a830193a9272a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15666656$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15059721$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ORSONI, Jelka G</creatorcontrib><creatorcontrib>ZAVOTA, Laura</creatorcontrib><creatorcontrib>VINCENTI, Vincenzo</creatorcontrib><creatorcontrib>PELLISTRI, Isabella</creatorcontrib><creatorcontrib>RAMA, Paolo</creatorcontrib><title>Cogan Syndrome in children: Early diagnosis and treatment is critical to prognosis</title><title>American journal of ophthalmology</title><addtitle>Am J Ophthalmol</addtitle><description>To present two cases of pediatric Cogan Syndrome and to highlight the differences between the adult and pediatric forms of the disease, as well as the importance of early diagnosis and treatment.
Interventional case report.
Institutional setting.
Corneal lesions were much more diffuse than those observed in adult Cogan syndrome. Immunosuppressive drug combination therapy successfully resolved systemic and ocular inflammation, but the involvement of the pupillary area caused permanent low vision in one case and amblyopia in the other.
When chronic ocular inflammation is observed in association with sensory neural hearing loss and any systemic signs of autoimmune inflammation, a diagnosis of Cogan syndrome should be suspected. If immunosuppressive treatment is not initiated as soon as possible, permanent low vision and deafness can result.</description><subject>Amblyopia - etiology</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</subject><subject>Aspirin - therapeutic use</subject><subject>Autoimmune Diseases - complications</subject><subject>Autoimmune Diseases - diagnosis</subject><subject>Autoimmune Diseases - drug therapy</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cyclosporine - therapeutic use</subject><subject>Diseases of cornea, anterior segment and sclera</subject><subject>Drug Therapy, Combination</subject><subject>Fludrocortisone - therapeutic use</subject><subject>Hearing Loss, Sensorineural - complications</subject><subject>Hearing Loss, Sensorineural - diagnosis</subject><subject>Hearing Loss, Sensorineural - drug therapy</subject><subject>Humans</subject><subject>Immunosuppressive Agents - therapeutic use</subject><subject>Keratitis - complications</subject><subject>Keratitis - diagnosis</subject><subject>Keratitis - drug therapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methotrexate - therapeutic use</subject><subject>Ophthalmology</subject><subject>Prognosis</subject><subject>Syndrome</subject><subject>Vasculitis - complications</subject><subject>Vasculitis - diagnosis</subject><subject>Vasculitis - drug therapy</subject><subject>Vision, Low - etiology</subject><issn>0002-9394</issn><issn>1879-1891</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkEtLxDAQgIMouj5-gpKLoodqJtk2jTdZfIEg-ABvYZqkGmlTTbqH_fdGd1HnMszwzQzzEbIP7BQYVGePjDFeKKGmx0ycMADOi5c1MoFaqgJqBetk8otske2U3nNZyancJFtQslJJDhPyMBteMdDHRbBx6B31gZo339nowjm9xNgtqPX4GobkE8Vg6Rgdjr0LI80NE_3oDXZ0HOhHHJbYLtlosUtub5V3yPPV5dPspri7v76dXdwVRohyLJrKCAmVQGktIFiLthZGsZYBa-u6xcaUygrZYKmmXDai4lgLBkqg4pKj2CFHy7358ufcpVH3PhnXdRjcME9aglQ8v5nBcgmaOKQUXas_ou8xLjQw_S1T_8jU36Y0E_pHpn7JcwerA_Omd_ZvamUvA4crAFO20EYMxqd_XJWjrMQXtLB84Q</recordid><startdate>20040401</startdate><enddate>20040401</enddate><creator>ORSONI, Jelka G</creator><creator>ZAVOTA, Laura</creator><creator>VINCENTI, Vincenzo</creator><creator>PELLISTRI, Isabella</creator><creator>RAMA, Paolo</creator><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040401</creationdate><title>Cogan Syndrome in children: Early diagnosis and treatment is critical to prognosis</title><author>ORSONI, Jelka G ; ZAVOTA, Laura ; VINCENTI, Vincenzo ; PELLISTRI, Isabella ; RAMA, Paolo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c335t-b6c37163a7dd1a1ddad83c90f010f88fabc59d37ba59427b362a830193a9272a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Amblyopia - etiology</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</topic><topic>Aspirin - therapeutic use</topic><topic>Autoimmune Diseases - complications</topic><topic>Autoimmune Diseases - diagnosis</topic><topic>Autoimmune Diseases - drug therapy</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cyclosporine - therapeutic use</topic><topic>Diseases of cornea, anterior segment and sclera</topic><topic>Drug Therapy, Combination</topic><topic>Fludrocortisone - therapeutic use</topic><topic>Hearing Loss, Sensorineural - complications</topic><topic>Hearing Loss, Sensorineural - diagnosis</topic><topic>Hearing Loss, Sensorineural - drug therapy</topic><topic>Humans</topic><topic>Immunosuppressive Agents - therapeutic use</topic><topic>Keratitis - complications</topic><topic>Keratitis - diagnosis</topic><topic>Keratitis - drug therapy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Methotrexate - therapeutic use</topic><topic>Ophthalmology</topic><topic>Prognosis</topic><topic>Syndrome</topic><topic>Vasculitis - complications</topic><topic>Vasculitis - diagnosis</topic><topic>Vasculitis - drug therapy</topic><topic>Vision, Low - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ORSONI, Jelka G</creatorcontrib><creatorcontrib>ZAVOTA, Laura</creatorcontrib><creatorcontrib>VINCENTI, Vincenzo</creatorcontrib><creatorcontrib>PELLISTRI, Isabella</creatorcontrib><creatorcontrib>RAMA, Paolo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ORSONI, Jelka G</au><au>ZAVOTA, Laura</au><au>VINCENTI, Vincenzo</au><au>PELLISTRI, Isabella</au><au>RAMA, Paolo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cogan Syndrome in children: Early diagnosis and treatment is critical to prognosis</atitle><jtitle>American journal of ophthalmology</jtitle><addtitle>Am J Ophthalmol</addtitle><date>2004-04-01</date><risdate>2004</risdate><volume>137</volume><issue>4</issue><spage>757</spage><epage>758</epage><pages>757-758</pages><issn>0002-9394</issn><eissn>1879-1891</eissn><coden>AJOPAA</coden><abstract>To present two cases of pediatric Cogan Syndrome and to highlight the differences between the adult and pediatric forms of the disease, as well as the importance of early diagnosis and treatment.
Interventional case report.
Institutional setting.
Corneal lesions were much more diffuse than those observed in adult Cogan syndrome. Immunosuppressive drug combination therapy successfully resolved systemic and ocular inflammation, but the involvement of the pupillary area caused permanent low vision in one case and amblyopia in the other.
When chronic ocular inflammation is observed in association with sensory neural hearing loss and any systemic signs of autoimmune inflammation, a diagnosis of Cogan syndrome should be suspected. If immunosuppressive treatment is not initiated as soon as possible, permanent low vision and deafness can result.</abstract><cop>New York, NY</cop><pub>Elsevier</pub><pmid>15059721</pmid><doi>10.1016/S0002-9394(03)01122-X</doi><tpages>2</tpages></addata></record> |
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| subjects | Amblyopia - etiology Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Aspirin - therapeutic use Autoimmune Diseases - complications Autoimmune Diseases - diagnosis Autoimmune Diseases - drug therapy Biological and medical sciences Child Child, Preschool Cyclosporine - therapeutic use Diseases of cornea, anterior segment and sclera Drug Therapy, Combination Fludrocortisone - therapeutic use Hearing Loss, Sensorineural - complications Hearing Loss, Sensorineural - diagnosis Hearing Loss, Sensorineural - drug therapy Humans Immunosuppressive Agents - therapeutic use Keratitis - complications Keratitis - diagnosis Keratitis - drug therapy Male Medical sciences Methotrexate - therapeutic use Ophthalmology Prognosis Syndrome Vasculitis - complications Vasculitis - diagnosis Vasculitis - drug therapy Vision, Low - etiology |
| title | Cogan Syndrome in children: Early diagnosis and treatment is critical to prognosis |
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