Regulation of anti-filarial IgE by infection pressure
In lymphatic filariasis, specific IgG4 responses to the parasite and their relationship with infection have been studied extensively, but only a few studies have concentrated on anti-filarial and total IgE. Here we have investigated the role of filarial infection pressure on production of IgE by con...
Gespeichert in:
| Veröffentlicht in: | Parasitology 2002-05, Vol.124 (5), p.509-519 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 519 |
|---|---|
| container_issue | 5 |
| container_start_page | 509 |
| container_title | Parasitology |
| container_volume | 124 |
| creator | TERHELL, A. J. STOLK, W. A. HAARBRINK, M. MANGALI, A. VAN OORTMARSSEN, G. J. YAZDANBAKHSH, M. |
| description | In lymphatic filariasis, specific IgG4 responses to the parasite and their relationship with infection have been studied extensively, but only a few studies have concentrated on anti-filarial and total IgE. Here we have investigated the role of filarial infection pressure on production of IgE by considering length of exposure (age), filarial endemicity and parasitological status. Antibody levels were determined in 366 individuals, who were resident in 3 villages in South-Sulawesi, Indonesia, with varying degrees of filarial transmission intensity, as indicated by the prevalence of Brugia malayi microfilaraemia (0·7%, 9% and 32%, respectively). Anti-filarial IgE levels were significantly lower in the low transmission village than in the areas with intermediate and high filarial transmission; however, in the latter village a remarkable suppression of specific IgE was found. Microfilaria-positive individuals showed elevated levels of total IgE, but suppression of specific IgE, which has been reported before. Taken together, these observations suggest that 2 opposing mechanisms regulate anti-parasite IgE expression: increasing experience of filarial infection stimulates specific IgE, but antibody levels become specifically suppressed when microfilariae or adult worms develop. Using a simple mathematical model, we illustrate how anti-filarial IgE increases with parasite antigen up to a threshold level, but levels off and becomes down-regulated after the threshold is exceeded. |
| doi_str_mv | 10.1017/S0031182002001543 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71792468</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cupid>10_1017_S0031182002001543</cupid><sourcerecordid>71792468</sourcerecordid><originalsourceid>FETCH-LOGICAL-c436t-75001d84e83ab651954260d01f0d8194c4a6176e327c543d3378fef17b4a1edd3</originalsourceid><addsrcrecordid>eNp1kF1LwzAUhoMobn78AG-kCHpXzUnSpL3UMacgiF8I3oS0TUZm186kBffvzVxxoAiBXLzPOTznRegI8DlgEBdPGFOAlGAcHiSMbqEhMJ7FKXDYRsNVHK_yAdrzfoYx5pSTXTQAglnGgA5R8qinXaVa29RRYyJVtzY2tlLOqiq6nY6jfBnZ2ujim1g47X3n9AHaMary-rD_99HL9fh5dBPf3U9uR5d3ccEob2ORBK0yZTqlKucJZAkjHJcYDC5TyFjBFAfBNSWiCPYlpSI12oDImQJdlnQfna33Llzz0Wnfyrn1ha4qVeum81KAyAjjaQBPfoGzpnN1cJMkNEKISGiAYA0VrvHeaSMXzs6VW0rAclWo_FNomDnuF3f5XJebib7BAJz2gPKFqoxTdWH9hqMZZcBJ4OI1Z32rP39y5d4lF1Qkkk8epKBvV_x18ihXF9FeVs1zZ8up3pz0v-4XWCuYCA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>214622753</pqid></control><display><type>article</type><title>Regulation of anti-filarial IgE by infection pressure</title><source>MEDLINE</source><source>Cambridge University Press Journals Complete</source><creator>TERHELL, A. J. ; STOLK, W. A. ; HAARBRINK, M. ; MANGALI, A. ; VAN OORTMARSSEN, G. J. ; YAZDANBAKHSH, M.</creator><creatorcontrib>TERHELL, A. J. ; STOLK, W. A. ; HAARBRINK, M. ; MANGALI, A. ; VAN OORTMARSSEN, G. J. ; YAZDANBAKHSH, M.</creatorcontrib><description>In lymphatic filariasis, specific IgG4 responses to the parasite and their relationship with infection have been studied extensively, but only a few studies have concentrated on anti-filarial and total IgE. Here we have investigated the role of filarial infection pressure on production of IgE by considering length of exposure (age), filarial endemicity and parasitological status. Antibody levels were determined in 366 individuals, who were resident in 3 villages in South-Sulawesi, Indonesia, with varying degrees of filarial transmission intensity, as indicated by the prevalence of Brugia malayi microfilaraemia (0·7%, 9% and 32%, respectively). Anti-filarial IgE levels were significantly lower in the low transmission village than in the areas with intermediate and high filarial transmission; however, in the latter village a remarkable suppression of specific IgE was found. Microfilaria-positive individuals showed elevated levels of total IgE, but suppression of specific IgE, which has been reported before. Taken together, these observations suggest that 2 opposing mechanisms regulate anti-parasite IgE expression: increasing experience of filarial infection stimulates specific IgE, but antibody levels become specifically suppressed when microfilariae or adult worms develop. Using a simple mathematical model, we illustrate how anti-filarial IgE increases with parasite antigen up to a threshold level, but levels off and becomes down-regulated after the threshold is exceeded.</description><identifier>ISSN: 0031-1820</identifier><identifier>EISSN: 1469-8161</identifier><identifier>DOI: 10.1017/S0031182002001543</identifier><identifier>PMID: 12049413</identifier><identifier>CODEN: PARAAE</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Adolescent ; Adult ; Animals ; Antibodies, Helminth - blood ; Antibody Specificity ; Antigens, Helminth - immunology ; Biological and medical sciences ; Brugia malayi ; Brugia malayi - immunology ; Brugia malayi - pathogenicity ; Child ; Child, Preschool ; Diseases caused by nematodes ; Female ; Filariases ; Filariasis - immunology ; Filariasis - parasitology ; Filariasis - transmission ; Helminthic diseases ; Humans ; IgE ; IgG4 ; Immunoglobulin E - blood ; infection ; Infectious diseases ; Linear Models ; Lymphatic filariases ; Male ; Medical sciences ; microfilaria ; Middle Aged ; Models, Biological ; Parasites ; Parasitic diseases ; transmission intensity ; Tropical medicine ; Vector-borne diseases</subject><ispartof>Parasitology, 2002-05, Vol.124 (5), p.509-519</ispartof><rights>2002 Cambridge University Press</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-75001d84e83ab651954260d01f0d8194c4a6176e327c543d3378fef17b4a1edd3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0031182002001543/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,776,780,27901,27902,55603</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13934162$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12049413$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TERHELL, A. J.</creatorcontrib><creatorcontrib>STOLK, W. A.</creatorcontrib><creatorcontrib>HAARBRINK, M.</creatorcontrib><creatorcontrib>MANGALI, A.</creatorcontrib><creatorcontrib>VAN OORTMARSSEN, G. J.</creatorcontrib><creatorcontrib>YAZDANBAKHSH, M.</creatorcontrib><title>Regulation of anti-filarial IgE by infection pressure</title><title>Parasitology</title><addtitle>Parasitology</addtitle><description>In lymphatic filariasis, specific IgG4 responses to the parasite and their relationship with infection have been studied extensively, but only a few studies have concentrated on anti-filarial and total IgE. Here we have investigated the role of filarial infection pressure on production of IgE by considering length of exposure (age), filarial endemicity and parasitological status. Antibody levels were determined in 366 individuals, who were resident in 3 villages in South-Sulawesi, Indonesia, with varying degrees of filarial transmission intensity, as indicated by the prevalence of Brugia malayi microfilaraemia (0·7%, 9% and 32%, respectively). Anti-filarial IgE levels were significantly lower in the low transmission village than in the areas with intermediate and high filarial transmission; however, in the latter village a remarkable suppression of specific IgE was found. Microfilaria-positive individuals showed elevated levels of total IgE, but suppression of specific IgE, which has been reported before. Taken together, these observations suggest that 2 opposing mechanisms regulate anti-parasite IgE expression: increasing experience of filarial infection stimulates specific IgE, but antibody levels become specifically suppressed when microfilariae or adult worms develop. Using a simple mathematical model, we illustrate how anti-filarial IgE increases with parasite antigen up to a threshold level, but levels off and becomes down-regulated after the threshold is exceeded.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Animals</subject><subject>Antibodies, Helminth - blood</subject><subject>Antibody Specificity</subject><subject>Antigens, Helminth - immunology</subject><subject>Biological and medical sciences</subject><subject>Brugia malayi</subject><subject>Brugia malayi - immunology</subject><subject>Brugia malayi - pathogenicity</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Diseases caused by nematodes</subject><subject>Female</subject><subject>Filariases</subject><subject>Filariasis - immunology</subject><subject>Filariasis - parasitology</subject><subject>Filariasis - transmission</subject><subject>Helminthic diseases</subject><subject>Humans</subject><subject>IgE</subject><subject>IgG4</subject><subject>Immunoglobulin E - blood</subject><subject>infection</subject><subject>Infectious diseases</subject><subject>Linear Models</subject><subject>Lymphatic filariases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>microfilaria</subject><subject>Middle Aged</subject><subject>Models, Biological</subject><subject>Parasites</subject><subject>Parasitic diseases</subject><subject>transmission intensity</subject><subject>Tropical medicine</subject><subject>Vector-borne diseases</subject><issn>0031-1820</issn><issn>1469-8161</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kF1LwzAUhoMobn78AG-kCHpXzUnSpL3UMacgiF8I3oS0TUZm186kBffvzVxxoAiBXLzPOTznRegI8DlgEBdPGFOAlGAcHiSMbqEhMJ7FKXDYRsNVHK_yAdrzfoYx5pSTXTQAglnGgA5R8qinXaVa29RRYyJVtzY2tlLOqiq6nY6jfBnZ2ujim1g47X3n9AHaMary-rD_99HL9fh5dBPf3U9uR5d3ccEob2ORBK0yZTqlKucJZAkjHJcYDC5TyFjBFAfBNSWiCPYlpSI12oDImQJdlnQfna33Llzz0Wnfyrn1ha4qVeum81KAyAjjaQBPfoGzpnN1cJMkNEKISGiAYA0VrvHeaSMXzs6VW0rAclWo_FNomDnuF3f5XJebib7BAJz2gPKFqoxTdWH9hqMZZcBJ4OI1Z32rP39y5d4lF1Qkkk8epKBvV_x18ihXF9FeVs1zZ8up3pz0v-4XWCuYCA</recordid><startdate>20020501</startdate><enddate>20020501</enddate><creator>TERHELL, A. J.</creator><creator>STOLK, W. A.</creator><creator>HAARBRINK, M.</creator><creator>MANGALI, A.</creator><creator>VAN OORTMARSSEN, G. J.</creator><creator>YAZDANBAKHSH, M.</creator><general>Cambridge University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TM</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>P64</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20020501</creationdate><title>Regulation of anti-filarial IgE by infection pressure</title><author>TERHELL, A. J. ; STOLK, W. A. ; HAARBRINK, M. ; MANGALI, A. ; VAN OORTMARSSEN, G. J. ; YAZDANBAKHSH, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-75001d84e83ab651954260d01f0d8194c4a6176e327c543d3378fef17b4a1edd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Animals</topic><topic>Antibodies, Helminth - blood</topic><topic>Antibody Specificity</topic><topic>Antigens, Helminth - immunology</topic><topic>Biological and medical sciences</topic><topic>Brugia malayi</topic><topic>Brugia malayi - immunology</topic><topic>Brugia malayi - pathogenicity</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Diseases caused by nematodes</topic><topic>Female</topic><topic>Filariases</topic><topic>Filariasis - immunology</topic><topic>Filariasis - parasitology</topic><topic>Filariasis - transmission</topic><topic>Helminthic diseases</topic><topic>Humans</topic><topic>IgE</topic><topic>IgG4</topic><topic>Immunoglobulin E - blood</topic><topic>infection</topic><topic>Infectious diseases</topic><topic>Linear Models</topic><topic>Lymphatic filariases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>microfilaria</topic><topic>Middle Aged</topic><topic>Models, Biological</topic><topic>Parasites</topic><topic>Parasitic diseases</topic><topic>transmission intensity</topic><topic>Tropical medicine</topic><topic>Vector-borne diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TERHELL, A. J.</creatorcontrib><creatorcontrib>STOLK, W. A.</creatorcontrib><creatorcontrib>HAARBRINK, M.</creatorcontrib><creatorcontrib>MANGALI, A.</creatorcontrib><creatorcontrib>VAN OORTMARSSEN, G. J.</creatorcontrib><creatorcontrib>YAZDANBAKHSH, M.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Parasitology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TERHELL, A. J.</au><au>STOLK, W. A.</au><au>HAARBRINK, M.</au><au>MANGALI, A.</au><au>VAN OORTMARSSEN, G. J.</au><au>YAZDANBAKHSH, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regulation of anti-filarial IgE by infection pressure</atitle><jtitle>Parasitology</jtitle><addtitle>Parasitology</addtitle><date>2002-05-01</date><risdate>2002</risdate><volume>124</volume><issue>5</issue><spage>509</spage><epage>519</epage><pages>509-519</pages><issn>0031-1820</issn><eissn>1469-8161</eissn><coden>PARAAE</coden><abstract>In lymphatic filariasis, specific IgG4 responses to the parasite and their relationship with infection have been studied extensively, but only a few studies have concentrated on anti-filarial and total IgE. Here we have investigated the role of filarial infection pressure on production of IgE by considering length of exposure (age), filarial endemicity and parasitological status. Antibody levels were determined in 366 individuals, who were resident in 3 villages in South-Sulawesi, Indonesia, with varying degrees of filarial transmission intensity, as indicated by the prevalence of Brugia malayi microfilaraemia (0·7%, 9% and 32%, respectively). Anti-filarial IgE levels were significantly lower in the low transmission village than in the areas with intermediate and high filarial transmission; however, in the latter village a remarkable suppression of specific IgE was found. Microfilaria-positive individuals showed elevated levels of total IgE, but suppression of specific IgE, which has been reported before. Taken together, these observations suggest that 2 opposing mechanisms regulate anti-parasite IgE expression: increasing experience of filarial infection stimulates specific IgE, but antibody levels become specifically suppressed when microfilariae or adult worms develop. Using a simple mathematical model, we illustrate how anti-filarial IgE increases with parasite antigen up to a threshold level, but levels off and becomes down-regulated after the threshold is exceeded.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>12049413</pmid><doi>10.1017/S0031182002001543</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0031-1820 |
| ispartof | Parasitology, 2002-05, Vol.124 (5), p.509-519 |
| issn | 0031-1820 1469-8161 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71792468 |
| source | MEDLINE; Cambridge University Press Journals Complete |
| subjects | Adolescent Adult Animals Antibodies, Helminth - blood Antibody Specificity Antigens, Helminth - immunology Biological and medical sciences Brugia malayi Brugia malayi - immunology Brugia malayi - pathogenicity Child Child, Preschool Diseases caused by nematodes Female Filariases Filariasis - immunology Filariasis - parasitology Filariasis - transmission Helminthic diseases Humans IgE IgG4 Immunoglobulin E - blood infection Infectious diseases Linear Models Lymphatic filariases Male Medical sciences microfilaria Middle Aged Models, Biological Parasites Parasitic diseases transmission intensity Tropical medicine Vector-borne diseases |
| title | Regulation of anti-filarial IgE by infection pressure |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T22%3A01%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Regulation%20of%20anti-filarial%20IgE%20by%20infection%20pressure&rft.jtitle=Parasitology&rft.au=TERHELL,%20A.%C2%A0J.&rft.date=2002-05-01&rft.volume=124&rft.issue=5&rft.spage=509&rft.epage=519&rft.pages=509-519&rft.issn=0031-1820&rft.eissn=1469-8161&rft.coden=PARAAE&rft_id=info:doi/10.1017/S0031182002001543&rft_dat=%3Cproquest_cross%3E71792468%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=214622753&rft_id=info:pmid/12049413&rft_cupid=10_1017_S0031182002001543&rfr_iscdi=true |