Hepatopulmonary syndrome after living donor liver transplantation and deceased donor liver transplantation: A single‐center experience
Hepatopulmonary syndrome (HPS) is a progressive, debilitating complication of end‐stage liver disease. In contrast to the well‐established reversal of HPS after deceased donor liver transplantation (DDLT), little has been written about the natural course of HPS after the newer procedure of living do...
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| Veröffentlicht in: | Liver transplantation 2004-04, Vol.10 (4), p.529-533 |
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| container_title | Liver transplantation |
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| creator | Carey, Elizabeth J. Douglas, David D. Balan, Vijayan Vargas, Hugo E. Byrne, Thomas J. Moss, Adyr A. Mulligan, David C. |
| description | Hepatopulmonary syndrome (HPS) is a progressive, debilitating complication of end‐stage liver disease. In contrast to the well‐established reversal of HPS after deceased donor liver transplantation (DDLT), little has been written about the natural course of HPS after the newer procedure of living donor liver transplantation (LDLT). We describe HPS in a small series of 4 liver transplant recipients (2 DDLT; 2 LDLT) at a single center. Before transplantation, these 4 patients had a mean shunt fraction of 23.6 ± 14.3% and a mean PaO2 of 58.5 ± 11.3 mm Hg. All 4 patients used supplemental oxygen before transplantation. Sixteen weeks after transplantation, all 4 patients had normalized or improved shunt fraction and PaO2. These patients regained normal pulmonary function within a few months, despite the period of hepatic regeneration after LDLT. In conclusion, both DDLT and LDLT are associated with rapid and dramatic reversal of HPS. (Liver Transpl 2004;10:529–533.) |
| doi_str_mv | 10.1002/lt.20127 |
| format | Article |
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In contrast to the well‐established reversal of HPS after deceased donor liver transplantation (DDLT), little has been written about the natural course of HPS after the newer procedure of living donor liver transplantation (LDLT). We describe HPS in a small series of 4 liver transplant recipients (2 DDLT; 2 LDLT) at a single center. Before transplantation, these 4 patients had a mean shunt fraction of 23.6 ± 14.3% and a mean PaO2 of 58.5 ± 11.3 mm Hg. All 4 patients used supplemental oxygen before transplantation. Sixteen weeks after transplantation, all 4 patients had normalized or improved shunt fraction and PaO2. These patients regained normal pulmonary function within a few months, despite the period of hepatic regeneration after LDLT. In conclusion, both DDLT and LDLT are associated with rapid and dramatic reversal of HPS. 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In contrast to the well‐established reversal of HPS after deceased donor liver transplantation (DDLT), little has been written about the natural course of HPS after the newer procedure of living donor liver transplantation (LDLT). We describe HPS in a small series of 4 liver transplant recipients (2 DDLT; 2 LDLT) at a single center. Before transplantation, these 4 patients had a mean shunt fraction of 23.6 ± 14.3% and a mean PaO2 of 58.5 ± 11.3 mm Hg. All 4 patients used supplemental oxygen before transplantation. Sixteen weeks after transplantation, all 4 patients had normalized or improved shunt fraction and PaO2. These patients regained normal pulmonary function within a few months, despite the period of hepatic regeneration after LDLT. In conclusion, both DDLT and LDLT are associated with rapid and dramatic reversal of HPS. (Liver Transpl 2004;10:529–533.)</description><subject>Adult</subject><subject>Female</subject><subject>Hepatopulmonary Syndrome - diagnosis</subject><subject>Hepatopulmonary Syndrome - etiology</subject><subject>Hepatopulmonary Syndrome - surgery</subject><subject>Humans</subject><subject>Liver Regeneration - physiology</subject><subject>Liver Transplantation - adverse effects</subject><subject>Living Donors</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Treatment Outcome</subject><issn>1527-6465</issn><issn>1527-6473</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1PwzAQQC0EoqUg8QtQJsQS8OXLDltVAUWqxAJz5NhnFOTYwU6BboyM_EZ-CYFWMMHk8-np6fQIOQR6CpQmZ6Y_TSgkbIuMIU9YXGQs3f6Zi3xE9kJ4oBQgL-kuGUFOM87KYkze5tiJ3nVL0zor_CoKK6u8azESukcfmeapsfeRctZ9f4ZV74UNnRG2F33jbCSsihRKFAHVf-B5NI3CIDP48fou0X7p8aVD36CVuE92tDABDzbvhNxdXtzO5vHi5up6Nl3EMgXGYiyB1RlPCi5BYk615hmnOs8Eo7VSusZE5gWTUHDgjDFIVVYCp1yjBlGLdEKO197Ou8clhr5qmyDRDGeiW4aKASsToNkAnqxB6V0IHnXV-aYdElVAq6_qlemr7-oDerRxLusW1S-4yTwA8Rp4bgyu_hRVi9u18BOB2Y-t</recordid><startdate>200404</startdate><enddate>200404</enddate><creator>Carey, Elizabeth J.</creator><creator>Douglas, David D.</creator><creator>Balan, Vijayan</creator><creator>Vargas, Hugo E.</creator><creator>Byrne, Thomas J.</creator><creator>Moss, Adyr A.</creator><creator>Mulligan, David C.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200404</creationdate><title>Hepatopulmonary syndrome after living donor liver transplantation and deceased donor liver transplantation: A single‐center experience</title><author>Carey, Elizabeth J. ; Douglas, David D. ; Balan, Vijayan ; Vargas, Hugo E. ; Byrne, Thomas J. ; Moss, Adyr A. ; Mulligan, David C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3177-e917b48268c1ce50ff8480f54a70bddfbe2c567c1681877713d491808fef1aba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Female</topic><topic>Hepatopulmonary Syndrome - diagnosis</topic><topic>Hepatopulmonary Syndrome - etiology</topic><topic>Hepatopulmonary Syndrome - surgery</topic><topic>Humans</topic><topic>Liver Regeneration - physiology</topic><topic>Liver Transplantation - adverse effects</topic><topic>Living Donors</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carey, Elizabeth J.</creatorcontrib><creatorcontrib>Douglas, David D.</creatorcontrib><creatorcontrib>Balan, Vijayan</creatorcontrib><creatorcontrib>Vargas, Hugo E.</creatorcontrib><creatorcontrib>Byrne, Thomas J.</creatorcontrib><creatorcontrib>Moss, Adyr A.</creatorcontrib><creatorcontrib>Mulligan, David C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Liver transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carey, Elizabeth J.</au><au>Douglas, David D.</au><au>Balan, Vijayan</au><au>Vargas, Hugo E.</au><au>Byrne, Thomas J.</au><au>Moss, Adyr A.</au><au>Mulligan, David C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hepatopulmonary syndrome after living donor liver transplantation and deceased donor liver transplantation: A single‐center experience</atitle><jtitle>Liver transplantation</jtitle><addtitle>Liver Transpl</addtitle><date>2004-04</date><risdate>2004</risdate><volume>10</volume><issue>4</issue><spage>529</spage><epage>533</epage><pages>529-533</pages><issn>1527-6465</issn><eissn>1527-6473</eissn><abstract>Hepatopulmonary syndrome (HPS) is a progressive, debilitating complication of end‐stage liver disease. In contrast to the well‐established reversal of HPS after deceased donor liver transplantation (DDLT), little has been written about the natural course of HPS after the newer procedure of living donor liver transplantation (LDLT). We describe HPS in a small series of 4 liver transplant recipients (2 DDLT; 2 LDLT) at a single center. Before transplantation, these 4 patients had a mean shunt fraction of 23.6 ± 14.3% and a mean PaO2 of 58.5 ± 11.3 mm Hg. All 4 patients used supplemental oxygen before transplantation. Sixteen weeks after transplantation, all 4 patients had normalized or improved shunt fraction and PaO2. These patients regained normal pulmonary function within a few months, despite the period of hepatic regeneration after LDLT. In conclusion, both DDLT and LDLT are associated with rapid and dramatic reversal of HPS. 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| ispartof | Liver transplantation, 2004-04, Vol.10 (4), p.529-533 |
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| subjects | Adult Female Hepatopulmonary Syndrome - diagnosis Hepatopulmonary Syndrome - etiology Hepatopulmonary Syndrome - surgery Humans Liver Regeneration - physiology Liver Transplantation - adverse effects Living Donors Male Middle Aged Treatment Outcome |
| title | Hepatopulmonary syndrome after living donor liver transplantation and deceased donor liver transplantation: A single‐center experience |
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