Putting the heat on ALS

Putting the heat on ALS

An enhancer of the heat shock response alleviates symptoms of neurodegeneration and prolongs lifespan in a mouse model of amyotrophic lateral sclerosis--even when administered after onset.

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Bibliographische Detailangaben
Veröffentlicht in:Nature medicine 2004-04, Vol.10 (4), p.345-347
Hauptverfasser: Benn, Susanna C, Brown, Robert H
Format: Artikel
Sprache:eng
Schlagworte:
Amyotrophic Lateral Sclerosis - drug therapy
Amyotrophic Lateral Sclerosis - genetics
Amyotrophic Lateral Sclerosis - physiopathology
Animals
Disease Models, Animal
Heat-Shock Response
Hydroxylamines - pharmacology
Hydroxylamines - therapeutic use
Life Expectancy
Mice
Superoxide Dismutase - genetics
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Beschreibung
Zusammenfassung:An enhancer of the heat shock response alleviates symptoms of neurodegeneration and prolongs lifespan in a mouse model of amyotrophic lateral sclerosis--even when administered after onset.
ISSN:1078-8956
1546-170X
DOI:10.1038/nm0404-345