Study of ultrasonic contrast agents using a dual-frequency band technique
We have developed a dual-frequency band technique to study frequency-dependent phenomena associated with ultrasonic contrast agents. Our technique uses a superimposed high-frequency (10 MHz) broad-band ultrasound (US) pulse to investigate contrast agent interaction with a low-frequency ( e.g., 0.5 M...
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| Veröffentlicht in: | Ultrasound in medicine & biology 2000-06, Vol.26 (5), p.819-831 |
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| container_title | Ultrasound in medicine & biology |
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| creator | Deng, Cheri X Lizzi, Frederic L Kalisz, Andrew Rosado, Angel Silverman, Ronald H Coleman, D.Jackson |
| description | We have developed a dual-frequency band technique to study frequency-dependent phenomena associated with ultrasonic contrast agents. Our technique uses a superimposed high-frequency (10 MHz) broad-band ultrasound (US) pulse to investigate contrast agent interaction with a low-frequency (
e.g., 0.5 MHz) ultrasonic field. Our digitally controlled system has the ability to produce two colinear, confocal US pulses at different center frequencies, to adjust the relative phasing and pulse repetition frequency of each pulse, and to acquire digital backscatter data. A series of experimental studies demonstrated that the high-frequency backscatter signal responded to several phenomena induced in contrast agent particles by the low-frequency beam. These phenomena included radial pulsations, nonlinear oscillations and depletion. Initial results also demonstrated a relative phase shift between the high- and low-frequency signals; this shift is due to a difference in sound velocity at these frequencies, and it may convey information about the contrast agent concentration. |
| doi_str_mv | 10.1016/S0301-5629(00)00217-9 |
| format | Article |
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e.g., 0.5 MHz) ultrasonic field. Our digitally controlled system has the ability to produce two colinear, confocal US pulses at different center frequencies, to adjust the relative phasing and pulse repetition frequency of each pulse, and to acquire digital backscatter data. A series of experimental studies demonstrated that the high-frequency backscatter signal responded to several phenomena induced in contrast agent particles by the low-frequency beam. These phenomena included radial pulsations, nonlinear oscillations and depletion. Initial results also demonstrated a relative phase shift between the high- and low-frequency signals; this shift is due to a difference in sound velocity at these frequencies, and it may convey information about the contrast agent concentration.</description><subject>Albumins - chemistry</subject><subject>Backscattering</subject><subject>Biological and medical sciences</subject><subject>Contrast agents</subject><subject>Contrast media</subject><subject>Contrast Media - chemistry</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Measurement of contrast agents</subject><subject>Medical imaging</subject><subject>Medical sciences</subject><subject>Microspheres</subject><subject>Miscellaneous. 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Technology</topic><topic>Models, Theoretical</topic><topic>Phase shift</topic><topic>Sonication</topic><topic>Ultrasonic interaction</topic><topic>Ultrasonic investigative techniques</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Deng, Cheri X</creatorcontrib><creatorcontrib>Lizzi, Frederic L</creatorcontrib><creatorcontrib>Kalisz, Andrew</creatorcontrib><creatorcontrib>Rosado, Angel</creatorcontrib><creatorcontrib>Silverman, Ronald H</creatorcontrib><creatorcontrib>Coleman, D.Jackson</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Ultrasound in medicine & biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Deng, Cheri X</au><au>Lizzi, Frederic L</au><au>Kalisz, Andrew</au><au>Rosado, Angel</au><au>Silverman, Ronald H</au><au>Coleman, D.Jackson</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Study of ultrasonic contrast agents using a dual-frequency band technique</atitle><jtitle>Ultrasound in medicine & biology</jtitle><addtitle>Ultrasound Med Biol</addtitle><date>2000-06-01</date><risdate>2000</risdate><volume>26</volume><issue>5</issue><spage>819</spage><epage>831</epage><pages>819-831</pages><issn>0301-5629</issn><eissn>1879-291X</eissn><coden>USMBA3</coden><abstract>We have developed a dual-frequency band technique to study frequency-dependent phenomena associated with ultrasonic contrast agents. 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| ispartof | Ultrasound in medicine & biology, 2000-06, Vol.26 (5), p.819-831 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Albumins - chemistry Backscattering Biological and medical sciences Contrast agents Contrast media Contrast Media - chemistry Investigative techniques, diagnostic techniques (general aspects) Measurement of contrast agents Medical imaging Medical sciences Microspheres Miscellaneous. Technology Models, Theoretical Phase shift Sonication Ultrasonic interaction Ultrasonic investigative techniques |
| title | Study of ultrasonic contrast agents using a dual-frequency band technique |
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