Markers of Disease Evolution: The Case of Tuberculosis
Abrupt changes in environmental conditions—broadly understood to include demographic and social dynamics—can seriously impact the local or global disease dynamics of a population. These changes in the evolutionary landscape, which may occur over relatively short time-scales, are very likely to play...
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Veröffentlicht in: | Journal of theoretical biology 2002-03, Vol.215 (2), p.227-237 |
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container_title | Journal of theoretical biology |
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creator | APARICIO, JUAN P. CAPURRO, ANGEL F. CASTILLO-CHAVEZ, CARLOS |
description | Abrupt changes in environmental conditions—broadly understood to include demographic and social dynamics—can seriously impact the local or global disease dynamics of a population. These changes in the evolutionary landscape, which may occur over relatively short time-scales, are very likely to play a critical role in disease evolution. The potential impact of demographic, social and epidemiological shifts on the evolution of tuberculosis epidemics in the United States over the past century and a half is the main subject of this article. Evidence is provided to support the hypothesis that the observed substantial decreases in the incidence of active tuberculosis are the result of abrupt reductions in the rates of disease progression. |
doi_str_mv | 10.1006/jtbi.2001.2489 |
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These changes in the evolutionary landscape, which may occur over relatively short time-scales, are very likely to play a critical role in disease evolution. The potential impact of demographic, social and epidemiological shifts on the evolution of tuberculosis epidemics in the United States over the past century and a half is the main subject of this article. 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Evidence is provided to support the hypothesis that the observed substantial decreases in the incidence of active tuberculosis are the result of abrupt reductions in the rates of disease progression.</description><subject>Disease Outbreaks</subject><subject>Disease Progression</subject><subject>Humans</subject><subject>Life Style</subject><subject>Models, Statistical</subject><subject>Nutritional Physiological Phenomena</subject><subject>Prevalence</subject><subject>Social Environment</subject><subject>Tuberculosis - epidemiology</subject><subject>Tuberculosis - microbiology</subject><subject>Tuberculosis - transmission</subject><subject>United States - epidemiology</subject><subject>Urbanization</subject><issn>0022-5193</issn><issn>1095-8541</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkD1PwzAURS0EoqWwMqJMbAnPsRMnbKiUD6mIpcyW4zwLl7QGO6nEv8dRKzEhFlu6Pr567xBySSGjAOXNum9slgPQLOdVfUSmFOoirQpOj8kUIM_TgtZsQs5CWANAzVl5SiY0hxiLckrKF-U_0IfEmeTeBlQBk8XOdUNv3fY2Wb1jMh-z-LwaGvR66Fyw4ZycGNUFvDjcM_L2sFjNn9Ll6-Pz_G6ZaiZon2pVtiXTpQahCtAc4lkUjWmMKRQK0RpDmziIMIpzpC3TzFAVORCMNy1lM3K97_307mvA0MuNDRq7Tm3RDUEKKuq4lfgXpBUHzugIZntQexeCRyM_vd0o_y0pyFGpHJXKUakclcYPV4fmodlg-4sfHEag2gMYRewsehm0xa3G1nrUvWyd_av7B02khGA</recordid><startdate>20020321</startdate><enddate>20020321</enddate><creator>APARICIO, JUAN P.</creator><creator>CAPURRO, ANGEL F.</creator><creator>CASTILLO-CHAVEZ, CARLOS</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20020321</creationdate><title>Markers of Disease Evolution: The Case of Tuberculosis</title><author>APARICIO, JUAN P. ; CAPURRO, ANGEL F. ; CASTILLO-CHAVEZ, CARLOS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-ca6d63c6c07a50c40a5055bfbff5ae77dff1b1977fa44e1d3c3f1ac400734bd13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Disease Outbreaks</topic><topic>Disease Progression</topic><topic>Humans</topic><topic>Life Style</topic><topic>Models, Statistical</topic><topic>Nutritional Physiological Phenomena</topic><topic>Prevalence</topic><topic>Social Environment</topic><topic>Tuberculosis - epidemiology</topic><topic>Tuberculosis - microbiology</topic><topic>Tuberculosis - transmission</topic><topic>United States - epidemiology</topic><topic>Urbanization</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>APARICIO, JUAN P.</creatorcontrib><creatorcontrib>CAPURRO, ANGEL F.</creatorcontrib><creatorcontrib>CASTILLO-CHAVEZ, CARLOS</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of theoretical biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>APARICIO, JUAN P.</au><au>CAPURRO, ANGEL F.</au><au>CASTILLO-CHAVEZ, CARLOS</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Markers of Disease Evolution: The Case of Tuberculosis</atitle><jtitle>Journal of theoretical biology</jtitle><addtitle>J Theor Biol</addtitle><date>2002-03-21</date><risdate>2002</risdate><volume>215</volume><issue>2</issue><spage>227</spage><epage>237</epage><pages>227-237</pages><issn>0022-5193</issn><eissn>1095-8541</eissn><abstract>Abrupt changes in environmental conditions—broadly understood to include demographic and social dynamics—can seriously impact the local or global disease dynamics of a population. 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subjects | Disease Outbreaks Disease Progression Humans Life Style Models, Statistical Nutritional Physiological Phenomena Prevalence Social Environment Tuberculosis - epidemiology Tuberculosis - microbiology Tuberculosis - transmission United States - epidemiology Urbanization |
title | Markers of Disease Evolution: The Case of Tuberculosis |
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