Hypocretin‐1 (orexin‐A) concentrations in cerebrospinal fluid are low in patients with Guillain–Barré syndrome
It is reported that cerebrospinal fluid (CSF) hypocretin‐1 (orexin‐A) concentrations in patients with narcolepsy are significantly low. Human narcolepsy is also known to be closely associated with a specific human histocompatibility leukocyte antigen (HLA), suggesting that autoimmunity is involved i...
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| Veröffentlicht in: | Psychiatry and clinical neurosciences 2002-06, Vol.56 (3), p.273-274 |
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| creator | KANBAYASHI, TAKASHI ISHIGURO, HIDEAKI AIZAWA, RIKA SAITO, YASUSHI OGAWA, YURIKO ABE, MASAHITO HIROTA, KOUICHI NISHINO, SEIJI SHIMIZU, TETSUO |
| description | It is reported that cerebrospinal fluid (CSF) hypocretin‐1 (orexin‐A) concentrations in patients with narcolepsy are significantly low. Human narcolepsy is also known to be closely associated with a specific human histocompatibility leukocyte antigen (HLA), suggesting that autoimmunity is involved in the pathophysiology of the disease. Thus, it is important to know whether hypocretin changes are found in definite neuroimmunological diseases such as multiple sclerosis and Guillain–Barré syndrome (GBS). The results of the present study indicate that some patients with GBS have lower levels of CSF hypocretin‐1. |
| doi_str_mv | 10.1046/j.1440-1819.2002.00974.x |
| format | Article |
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Human narcolepsy is also known to be closely associated with a specific human histocompatibility leukocyte antigen (HLA), suggesting that autoimmunity is involved in the pathophysiology of the disease. Thus, it is important to know whether hypocretin changes are found in definite neuroimmunological diseases such as multiple sclerosis and Guillain–Barré syndrome (GBS). The results of the present study indicate that some patients with GBS have lower levels of CSF hypocretin‐1.</description><identifier>ISSN: 1323-1316</identifier><identifier>EISSN: 1440-1819</identifier><identifier>DOI: 10.1046/j.1440-1819.2002.00974.x</identifier><identifier>PMID: 12047592</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Science Pty</publisher><subject>Alzheimer’s disease ; Analysis of Variance ; Carrier Proteins - cerebrospinal fluid ; Carrier Proteins - immunology ; cerebrospinal fluid ; Female ; Guillain-Barre Syndrome - cerebrospinal fluid ; Guillain-Barre Syndrome - immunology ; Guillain–Barré syndrome ; HLA Antigens - immunology ; Humans ; hypocretin ; Intracellular Signaling Peptides and Proteins ; Male ; multiple sclerosis ; Multiple Sclerosis - cerebrospinal fluid ; narcolepsy ; Neuropeptides - cerebrospinal fluid ; Neuropeptides - immunology ; orexin ; Orexins</subject><ispartof>Psychiatry and clinical neurosciences, 2002-06, Vol.56 (3), p.273-274</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4674-42d2b9f8d7b60708bfad204cd6ab6d4a88d306531278433b30abff047ef39f853</citedby><cites>FETCH-LOGICAL-c4674-42d2b9f8d7b60708bfad204cd6ab6d4a88d306531278433b30abff047ef39f853</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1440-1819.2002.00974.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1440-1819.2002.00974.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27923,27924,45573,45574,46408,46832</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12047592$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KANBAYASHI, TAKASHI</creatorcontrib><creatorcontrib>ISHIGURO, HIDEAKI</creatorcontrib><creatorcontrib>AIZAWA, RIKA</creatorcontrib><creatorcontrib>SAITO, YASUSHI</creatorcontrib><creatorcontrib>OGAWA, YURIKO</creatorcontrib><creatorcontrib>ABE, MASAHITO</creatorcontrib><creatorcontrib>HIROTA, KOUICHI</creatorcontrib><creatorcontrib>NISHINO, SEIJI</creatorcontrib><creatorcontrib>SHIMIZU, TETSUO</creatorcontrib><title>Hypocretin‐1 (orexin‐A) concentrations in cerebrospinal fluid are low in patients with Guillain–Barré syndrome</title><title>Psychiatry and clinical neurosciences</title><addtitle>Psychiatry Clin Neurosci</addtitle><description>It is reported that cerebrospinal fluid (CSF) hypocretin‐1 (orexin‐A) concentrations in patients with narcolepsy are significantly low. Human narcolepsy is also known to be closely associated with a specific human histocompatibility leukocyte antigen (HLA), suggesting that autoimmunity is involved in the pathophysiology of the disease. Thus, it is important to know whether hypocretin changes are found in definite neuroimmunological diseases such as multiple sclerosis and Guillain–Barré syndrome (GBS). The results of the present study indicate that some patients with GBS have lower levels of CSF hypocretin‐1.</description><subject>Alzheimer’s disease</subject><subject>Analysis of Variance</subject><subject>Carrier Proteins - cerebrospinal fluid</subject><subject>Carrier Proteins - immunology</subject><subject>cerebrospinal fluid</subject><subject>Female</subject><subject>Guillain-Barre Syndrome - cerebrospinal fluid</subject><subject>Guillain-Barre Syndrome - immunology</subject><subject>Guillain–Barré syndrome</subject><subject>HLA Antigens - immunology</subject><subject>Humans</subject><subject>hypocretin</subject><subject>Intracellular Signaling Peptides and Proteins</subject><subject>Male</subject><subject>multiple sclerosis</subject><subject>Multiple Sclerosis - cerebrospinal fluid</subject><subject>narcolepsy</subject><subject>Neuropeptides - cerebrospinal fluid</subject><subject>Neuropeptides - immunology</subject><subject>orexin</subject><subject>Orexins</subject><issn>1323-1316</issn><issn>1440-1819</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1OwzAQhS0EoqVwBeQVgkWCHbv5kdiUClqkCljA2nJiR7hK4mAnarPjCEicgnNwE06C01awxRuPNO-9mfkAgBj5GNHwculjSpGHY5z4AUKBj1ASUX-9B4a_jX1Xk4B4mOBwAI6sXSKECAnxIRjgANFonARD0M67WmdGNqr6fnvH8Fwbud7UkwuY6SqTVWN4o3RloapgJo1Mjba1qngB86JVAnIjYaFXfbt2SmewcKWaFzhrVVHwPuzjmhvz9QltVwmjS3kMDnJeWHmy-0fg-fbmaTr3Fg-zu-lk4WU0jKhHAxGkSR6LKA1RhOI058JtnomQp6GgPI4FQeGY4CCKKSEpQTzNc3eazImzjckInG1za6NfW2kbViqbSbdVJXVrWYSjOHHPCeOtMHPHWSNzVhtVctMxjFiPnC1ZT5b1ZFmPnG2Qs7Wznu5mtGkpxZ9xx9gJrraClSpk9-9g9ji9dwX5AYqalG4</recordid><startdate>200206</startdate><enddate>200206</enddate><creator>KANBAYASHI, TAKASHI</creator><creator>ISHIGURO, HIDEAKI</creator><creator>AIZAWA, RIKA</creator><creator>SAITO, YASUSHI</creator><creator>OGAWA, YURIKO</creator><creator>ABE, MASAHITO</creator><creator>HIROTA, KOUICHI</creator><creator>NISHINO, SEIJI</creator><creator>SHIMIZU, TETSUO</creator><general>Blackwell Science Pty</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200206</creationdate><title>Hypocretin‐1 (orexin‐A) concentrations in cerebrospinal fluid are low in patients with Guillain–Barré syndrome</title><author>KANBAYASHI, TAKASHI ; ISHIGURO, HIDEAKI ; AIZAWA, RIKA ; SAITO, YASUSHI ; OGAWA, YURIKO ; ABE, MASAHITO ; HIROTA, KOUICHI ; NISHINO, SEIJI ; SHIMIZU, TETSUO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4674-42d2b9f8d7b60708bfad204cd6ab6d4a88d306531278433b30abff047ef39f853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Alzheimer’s disease</topic><topic>Analysis of Variance</topic><topic>Carrier Proteins - cerebrospinal fluid</topic><topic>Carrier Proteins - immunology</topic><topic>cerebrospinal fluid</topic><topic>Female</topic><topic>Guillain-Barre Syndrome - cerebrospinal fluid</topic><topic>Guillain-Barre Syndrome - immunology</topic><topic>Guillain–Barré syndrome</topic><topic>HLA Antigens - immunology</topic><topic>Humans</topic><topic>hypocretin</topic><topic>Intracellular Signaling Peptides and Proteins</topic><topic>Male</topic><topic>multiple sclerosis</topic><topic>Multiple Sclerosis - cerebrospinal fluid</topic><topic>narcolepsy</topic><topic>Neuropeptides - cerebrospinal fluid</topic><topic>Neuropeptides - immunology</topic><topic>orexin</topic><topic>Orexins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KANBAYASHI, TAKASHI</creatorcontrib><creatorcontrib>ISHIGURO, HIDEAKI</creatorcontrib><creatorcontrib>AIZAWA, RIKA</creatorcontrib><creatorcontrib>SAITO, YASUSHI</creatorcontrib><creatorcontrib>OGAWA, YURIKO</creatorcontrib><creatorcontrib>ABE, MASAHITO</creatorcontrib><creatorcontrib>HIROTA, KOUICHI</creatorcontrib><creatorcontrib>NISHINO, SEIJI</creatorcontrib><creatorcontrib>SHIMIZU, TETSUO</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Psychiatry and clinical neurosciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KANBAYASHI, TAKASHI</au><au>ISHIGURO, HIDEAKI</au><au>AIZAWA, RIKA</au><au>SAITO, YASUSHI</au><au>OGAWA, YURIKO</au><au>ABE, MASAHITO</au><au>HIROTA, KOUICHI</au><au>NISHINO, SEIJI</au><au>SHIMIZU, TETSUO</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hypocretin‐1 (orexin‐A) concentrations in cerebrospinal fluid are low in patients with Guillain–Barré syndrome</atitle><jtitle>Psychiatry and clinical neurosciences</jtitle><addtitle>Psychiatry Clin Neurosci</addtitle><date>2002-06</date><risdate>2002</risdate><volume>56</volume><issue>3</issue><spage>273</spage><epage>274</epage><pages>273-274</pages><issn>1323-1316</issn><eissn>1440-1819</eissn><abstract>It is reported that cerebrospinal fluid (CSF) hypocretin‐1 (orexin‐A) concentrations in patients with narcolepsy are significantly low. Human narcolepsy is also known to be closely associated with a specific human histocompatibility leukocyte antigen (HLA), suggesting that autoimmunity is involved in the pathophysiology of the disease. Thus, it is important to know whether hypocretin changes are found in definite neuroimmunological diseases such as multiple sclerosis and Guillain–Barré syndrome (GBS). The results of the present study indicate that some patients with GBS have lower levels of CSF hypocretin‐1.</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Science Pty</pub><pmid>12047592</pmid><doi>10.1046/j.1440-1819.2002.00974.x</doi><tpages>2</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Free Content; Freely Accessible Japanese Titles; EZB-FREE-00999 freely available EZB journals; Wiley Online Library All Journals; Alma/SFX Local Collection |
| subjects | Alzheimer’s disease Analysis of Variance Carrier Proteins - cerebrospinal fluid Carrier Proteins - immunology cerebrospinal fluid Female Guillain-Barre Syndrome - cerebrospinal fluid Guillain-Barre Syndrome - immunology Guillain–Barré syndrome HLA Antigens - immunology Humans hypocretin Intracellular Signaling Peptides and Proteins Male multiple sclerosis Multiple Sclerosis - cerebrospinal fluid narcolepsy Neuropeptides - cerebrospinal fluid Neuropeptides - immunology orexin Orexins |
| title | Hypocretin‐1 (orexin‐A) concentrations in cerebrospinal fluid are low in patients with Guillain–Barré syndrome |
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