Endotoxin Induces Respiratory Failure and Increases Surfactant Turnover and Respiration Independent of Alveolocapillary Injury in Rats

Although endotoxin-induced acute lung injury is associated with inflammation, alveolocapillary injury, surfactant dysfunction, and altered lung mechanics, the precise sequence of these changes is polemic. We have studied the early pathogenesis of acute lung injury in spontaneously breathing anesthet...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 2002-06, Vol.165 (11), p.1516-1525
Hauptverfasser:	Davidson, Kate G, Bersten, Andrew D, Barr, Heather A, Dowling, Kay D, Nicholas, Terence E, Doyle, Ian R
Format:	Artikel
Sprache:	eng
Schlagworte:	Airway Resistance - physiology Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences Blood Gas Analysis Blood-Air Barrier - drug effects Blood-Air Barrier - physiology Capillary Permeability - drug effects Capillary Permeability - physiology Disease Models, Animal Emergency and intensive respiratory care Endotoxins - pharmacology Intensive care medicine Lung - metabolism Lung Injury Male Medical sciences Pulmonary Surfactants - metabolism Rats Rats, Sprague-Dawley Reference Values Respiratory Function Tests Respiratory Insufficiency - physiopathology Respiratory Mechanics Salmonella Sensitivity and Specificity Severity of Illness Index
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