KR‐31378 ameliorates atherosclerosis by blocking monocyte recruitment in hypercholestrolemic mice

The recruitment of monocytes into the artery wall is a crucial early step in atherogenesis. A novel compound, KR‐31378, has been shown to be a neuroprotective agent for ischemia‐reperfusion damage in rat brain via its potent antioxidant and antiapoptotic actions. Here, we report the effects of this...

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Veröffentlicht in:	The FASEB journal 2004-04, Vol.18 (6), p.714-716
Hauptverfasser:	Kim, Jiyun, Nam, Ki‐Hoan, Kim, Sun‐Ok, Choi, Jae‐Hoon, Kim, Hyoung‐Chin, Yang, Sung‐Don, Kang, Joo‐Hyoung, Ryu, Young‐Han, Taeg Oh, Goo, Yoo, Sung‐Eun
Format:	Artikel
Sprache:	eng
Schlagworte:	adhesion molecules Animals Arteriosclerosis - drug therapy Arteriosclerosis - immunology Arteriosclerosis - pathology Cell Adhesion - drug effects Chemotactic Factors - metabolism Chemotaxis - drug effects Diet, Atherogenic Guanidines - pharmacology Guanidines - therapeutic use Humans Hypercholesterolemia - etiology inflammation Mice Mice, Knockout Models, Biological Monocytes - cytology Monocytes - drug effects Monocytes - immunology NF-kappa B - metabolism nuclear factor‐κB Pyrans - pharmacology Pyrans - therapeutic use Tumor Necrosis Factor-alpha - antagonists & inhibitors Vascular Cell Adhesion Molecule-1 - metabolism
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