HIRA Is Critical for a Nucleosome Assembly Pathway Independent of DNA Synthesis

The mammalian HIRA gene encodes a histone-interacting protein whose homolog in Xenopus laevis is characterized here. In vitro, recombinant Xenopus HIRA bound purified core histones and promoted their deposition onto plasmid DNA. The Xenopus HIRA protein, tightly associated with nuclear structures in...

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Veröffentlicht in:	Molecular cell 2002-05, Vol.9 (5), p.1091-1100
Hauptverfasser:	Ray-Gallet, Dominique, Quivy, Jean-Pierre, Scamps, Christine, Martini, Emmanuelle M.-D, Lipinski, Marc, Almouzni, Geneviève
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Chromatin - metabolism DNA - metabolism DNA Replication Female Histones - metabolism Molecular Sequence Data Nuclear Proteins - physiology Nucleosomes - physiology Plasmids Transcription Factors - physiology Xenopus laevis
Online-Zugang:	Volltext
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