Fluticasone inhibits the progression of allergen-induced structural airway changes

Summary Background Inhaled corticosteroids are widely used as first‐line therapy in patients with asthma. The concept of early introduction is more and more accepted. Objective In our rat model of airway remodelling, we investigated whether treatment with inhaled fluticasone propionate can inhibit f...

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Veröffentlicht in:	Clinical and experimental allergy 2002-06, Vol.32 (6), p.914-920
Hauptverfasser:	Vanacker, N. J., Palmans, E., Pauwels, R. A., Kips, J. C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Administration, Topical Allergens - administration & dosage Allergens - adverse effects Allergens - drug effects Androstadienes - administration & dosage Animals Anti-Inflammatory Agents - administration & dosage Antibody Specificity - drug effects asthma Asthma - blood Asthma - drug therapy Asthma - etiology Biological and medical sciences Bronchoalveolar Lavage Fluid - cytology Carbachol - pharmacology Cholinergic Agonists - pharmacology Collagen - drug effects Collagen - metabolism corticosteroids Disease Models, Animal Disease Progression Dose-Response Relationship, Drug fibronectin Fibronectins - drug effects Fibronectins - metabolism Fluticasone Glucocorticoids goblet cells Histamine and antagonists. Allergy Immunoglobulin E - blood Immunoglobulin E - drug effects Leukocytes - drug effects Lung - blood supply Lung - metabolism Lung - pathology Male Medical sciences Ovalbumin - administration & dosage Ovalbumin - adverse effects Ovalbumin - drug effects Pharmacology. Drug treatments progression Rats remodeling Time Factors treatment
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