Piceatannol, a Syk-selective tyrosine kinase inhibitor, attenuated antigen challenge of guinea pig airways in vitro

Activation of nontransmembrane protein tyrosine kinases, such as Lyn and Syk, has been shown to be the earliest detectable signaling response to Fc receptor (FcεRI) cross-linking on mast cells leading to mast cell degranulation. The present study examined the effects of piceatannol (3,4,3′,5′-tetrah...

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Veröffentlicht in:	European journal of pharmacology 2002-05, Vol.443 (1), p.189-196
Hauptverfasser:	Seow, Cherng-Jye, Chue, Sung-Chian, Wong, W.S.Fred
Format:	Artikel
Sprache:	eng
Schlagworte:	Airway Obstruction - immunology Airway Obstruction - metabolism Airway Obstruction - physiopathology Anaphylaxis - immunology Anaphylaxis - metabolism Anaphylaxis - physiopathology Animals Arachidonic acid Biological and medical sciences Bronchoconstriction - drug effects Bronchoconstriction - immunology Bronchus Enzyme Inhibitors - pharmacology Enzyme Precursors - antagonists & inhibitors Enzyme-Linked Immunosorbent Assay General pharmacology Guinea Pigs Histamine Histamine and antagonists. Allergy Histamine Release - drug effects In Vitro Techniques Injections, Intraperitoneal Intracellular Signaling Peptides and Proteins Leukotriene D 4 Leukotrienes - metabolism Lung - drug effects Lung - immunology Lung - metabolism Male Medical sciences Ovalbumin Ovalbumin - immunology Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Protein-Tyrosine Kinases - antagonists & inhibitors Schultz–Dale reaction Stilbenes - pharmacology Syk Kinase
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