Carnosine uptake in rat choroid plexus primary cell cultures and choroid plexus whole tissue from PEPT2 null mice

PEPT2 is functionally active and localized to the apical membrane of rat choroid plexus epithelial cells. However, little is known about the transport mechanisms of endogenous neuropeptides in choroid plexus, and the role of PEPT2 in this process. In the present study, we examined the uptake kinetic...

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Veröffentlicht in:	Journal of neurochemistry 2004-04, Vol.89 (2), p.375-382
Hauptverfasser:	Teuscher, Nathan S., Shen, Hong, Shu, Cathaleen, Xiang, Jianming, Keep, Richard F., Smith, David E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Ageing, cell death Amino Acids - pharmacology Animals Biological and medical sciences Biological Transport - drug effects Biological Transport - physiology carnosine Carnosine - metabolism Carnosine - pharmacokinetics Cell physiology Cells, Cultured Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges choroid plexus Choroid Plexus - cytology Choroid Plexus - metabolism Diffusion Chambers, Culture Dipeptides - pharmacology Epithelial Cells - cytology Epithelial Cells - drug effects Epithelial Cells - metabolism Female Fundamental and applied biological sciences. Psychology Mice Mice, Knockout Molecular and cellular biology neuropeptides PEPT2 Rats Symporters - deficiency Symporters - genetics transport Vertebrates: nervous system and sense organs
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