On the occurrence of Leydig cell tumors in the F344 rat

Dunning began inbreeding, what is now the Fischer F344 rat, in 1931. Because of her publications showing a low incidence of spontaneous tumors to 35 months of age, we selected the F344 rat for most of the studies in the National Cancer Institute (NCI) Bioassay Program, beginning in 1964. We were sur...

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Veröffentlicht in:	Cancer letters 2002-08, Vol.182 (2), p.213-216
Hauptverfasser:	Weisburger, John H, Rivenson, Abraham, Reinhardt, Joel, Braley, Joanne, Pittman, Brian, Zang, Edith
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal tumors. Experimental tumors Animals Bioassays Biological and medical sciences Breast cancer Carcinogenesis Cell Transformation, Neoplastic Differentiation Functional gland Hypotheses Inbreeding Laboratory animals Leydig Cell Tumor - epidemiology Leydig Cell Tumor - genetics Leydig Cell Tumor - pathology Male Males Mating rat Medical sciences Non-functional gland Rats Rats, Inbred F344 Rodents Sexual Behavior, Animal Spontaneous animal tumors Testicular cancer Tumors Virgin rat
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