Induction of cell cycle arrest and p21(CIP1/WAF1) expression in human lung cancer cells by isoliquiritigenin
Isoliquiritigenin is a natural flavonoid isolated from licorice, shallot and bean sprouts. The effect of isoliquiritigenin on cell proliferation and cell cycle progression was examined in the A549 human lung cancer cell line. Isoliquiritigenin significantly inhibited the proliferation of lung cancer...
Gespeichert in:
| Veröffentlicht in: | Cancer letters 2004-04, Vol.207 (1), p.27-35 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 35 |
|---|---|
| container_issue | 1 |
| container_start_page | 27 |
| container_title | Cancer letters |
| container_volume | 207 |
| creator | Ii, Tsunehiro Satomi, Yoshiko Katoh, Daishiro Shimada, Junichi Baba, Masaki Okuyama, Toru Nishino, Hoyoku Kitamura, Nobuo |
| description | Isoliquiritigenin is a natural flavonoid isolated from licorice, shallot and bean sprouts. The effect of isoliquiritigenin on cell proliferation and cell cycle progression was examined in the A549 human lung cancer cell line. Isoliquiritigenin significantly inhibited the proliferation of lung cancer cells in a dose- and time-dependent manner. Flow cytometric analysis demonstrated that isoliquiritigenin restrained the cell cycle progression at G2/M phase. Further examinations using cDNA arrays and real-time quantitative RT-PCR revealed that isoliquiritigenin enhanced the expression of p21(CIP1/WAF1), a universal inhibitor of cyclin-dependent kinases. These results suggest that isoliquiritigenin will be a promising agent for use in chemopreventive or therapeutics against lung cancer. |
| doi_str_mv | 10.1016/j.canlet.2003.10.023 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_71782142</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>71782142</sourcerecordid><originalsourceid>FETCH-LOGICAL-p207t-4898b9561174fe904e8addcbbfeec36da1544a5923e6329f42e5a003e9e020133</originalsourceid><addsrcrecordid>eNo1UE1Lw0AU3INia_UfiOxJ9ND07Vc-jlKsFgp6UDyGzealbtls0mwC9t-baj09mDczzAwhNwwiBixe7CKjvcM-4gBihCLg4oxMQYCci1SoCbkMYQcASibqgkyYAgWJYFPi1r4cTG8bT5uKGnSOmoNxSHXXYeip9iVtObtfrt_Y4vNxxR4ofrfjKxwl1tOvodaeusFv6ZjBYPdrEmhxoDY0zu4H29nebtFbf0XOK-0CXp_ujHysnt6XL_PN6_N6-biZtxySfi7TLC0yFTOWyAozkJjqsjRFUSEaEZeaKSm1yrjAWPCskhyVHotjhsCBCTEjd3--bdfsh7FGXttwjKU9NkPIE5aknEk-Em9PxKGosczbzta6O-T_-4gfL0pm-g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71782142</pqid></control><display><type>article</type><title>Induction of cell cycle arrest and p21(CIP1/WAF1) expression in human lung cancer cells by isoliquiritigenin</title><source>MEDLINE</source><source>ScienceDirect Freedom Collection (Elsevier)</source><creator>Ii, Tsunehiro ; Satomi, Yoshiko ; Katoh, Daishiro ; Shimada, Junichi ; Baba, Masaki ; Okuyama, Toru ; Nishino, Hoyoku ; Kitamura, Nobuo</creator><creatorcontrib>Ii, Tsunehiro ; Satomi, Yoshiko ; Katoh, Daishiro ; Shimada, Junichi ; Baba, Masaki ; Okuyama, Toru ; Nishino, Hoyoku ; Kitamura, Nobuo</creatorcontrib><description>Isoliquiritigenin is a natural flavonoid isolated from licorice, shallot and bean sprouts. The effect of isoliquiritigenin on cell proliferation and cell cycle progression was examined in the A549 human lung cancer cell line. Isoliquiritigenin significantly inhibited the proliferation of lung cancer cells in a dose- and time-dependent manner. Flow cytometric analysis demonstrated that isoliquiritigenin restrained the cell cycle progression at G2/M phase. Further examinations using cDNA arrays and real-time quantitative RT-PCR revealed that isoliquiritigenin enhanced the expression of p21(CIP1/WAF1), a universal inhibitor of cyclin-dependent kinases. These results suggest that isoliquiritigenin will be a promising agent for use in chemopreventive or therapeutics against lung cancer.</description><identifier>ISSN: 0304-3835</identifier><identifier>DOI: 10.1016/j.canlet.2003.10.023</identifier><identifier>PMID: 15050731</identifier><language>eng</language><publisher>Ireland</publisher><subject>Cell Cycle ; Cell Division ; Cell Line, Tumor ; Chalcone - analogs & derivatives ; Chalcone - pharmacology ; Chalcones ; Cyclin-Dependent Kinase Inhibitor p21 ; Cyclins - biosynthesis ; DNA, Complementary - metabolism ; Dose-Response Relationship, Drug ; Enzyme Inhibitors - pharmacology ; Flavonoids - pharmacology ; Flow Cytometry ; G2 Phase ; Humans ; Lung Neoplasms - drug therapy ; Lung Neoplasms - metabolism ; Lung Neoplasms - pathology ; Mitosis ; Models, Chemical ; Nucleic Acid Hybridization ; Oligonucleotide Array Sequence Analysis ; Reverse Transcriptase Polymerase Chain Reaction ; RNA - metabolism ; Time Factors ; Up-Regulation</subject><ispartof>Cancer letters, 2004-04, Vol.207 (1), p.27-35</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15050731$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ii, Tsunehiro</creatorcontrib><creatorcontrib>Satomi, Yoshiko</creatorcontrib><creatorcontrib>Katoh, Daishiro</creatorcontrib><creatorcontrib>Shimada, Junichi</creatorcontrib><creatorcontrib>Baba, Masaki</creatorcontrib><creatorcontrib>Okuyama, Toru</creatorcontrib><creatorcontrib>Nishino, Hoyoku</creatorcontrib><creatorcontrib>Kitamura, Nobuo</creatorcontrib><title>Induction of cell cycle arrest and p21(CIP1/WAF1) expression in human lung cancer cells by isoliquiritigenin</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>Isoliquiritigenin is a natural flavonoid isolated from licorice, shallot and bean sprouts. The effect of isoliquiritigenin on cell proliferation and cell cycle progression was examined in the A549 human lung cancer cell line. Isoliquiritigenin significantly inhibited the proliferation of lung cancer cells in a dose- and time-dependent manner. Flow cytometric analysis demonstrated that isoliquiritigenin restrained the cell cycle progression at G2/M phase. Further examinations using cDNA arrays and real-time quantitative RT-PCR revealed that isoliquiritigenin enhanced the expression of p21(CIP1/WAF1), a universal inhibitor of cyclin-dependent kinases. These results suggest that isoliquiritigenin will be a promising agent for use in chemopreventive or therapeutics against lung cancer.</description><subject>Cell Cycle</subject><subject>Cell Division</subject><subject>Cell Line, Tumor</subject><subject>Chalcone - analogs & derivatives</subject><subject>Chalcone - pharmacology</subject><subject>Chalcones</subject><subject>Cyclin-Dependent Kinase Inhibitor p21</subject><subject>Cyclins - biosynthesis</subject><subject>DNA, Complementary - metabolism</subject><subject>Dose-Response Relationship, Drug</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Flavonoids - pharmacology</subject><subject>Flow Cytometry</subject><subject>G2 Phase</subject><subject>Humans</subject><subject>Lung Neoplasms - drug therapy</subject><subject>Lung Neoplasms - metabolism</subject><subject>Lung Neoplasms - pathology</subject><subject>Mitosis</subject><subject>Models, Chemical</subject><subject>Nucleic Acid Hybridization</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA - metabolism</subject><subject>Time Factors</subject><subject>Up-Regulation</subject><issn>0304-3835</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1UE1Lw0AU3INia_UfiOxJ9ND07Vc-jlKsFgp6UDyGzealbtls0mwC9t-baj09mDczzAwhNwwiBixe7CKjvcM-4gBihCLg4oxMQYCci1SoCbkMYQcASibqgkyYAgWJYFPi1r4cTG8bT5uKGnSOmoNxSHXXYeip9iVtObtfrt_Y4vNxxR4ofrfjKxwl1tOvodaeusFv6ZjBYPdrEmhxoDY0zu4H29nebtFbf0XOK-0CXp_ujHysnt6XL_PN6_N6-biZtxySfi7TLC0yFTOWyAozkJjqsjRFUSEaEZeaKSm1yrjAWPCskhyVHotjhsCBCTEjd3--bdfsh7FGXttwjKU9NkPIE5aknEk-Em9PxKGosczbzta6O-T_-4gfL0pm-g</recordid><startdate>20040415</startdate><enddate>20040415</enddate><creator>Ii, Tsunehiro</creator><creator>Satomi, Yoshiko</creator><creator>Katoh, Daishiro</creator><creator>Shimada, Junichi</creator><creator>Baba, Masaki</creator><creator>Okuyama, Toru</creator><creator>Nishino, Hoyoku</creator><creator>Kitamura, Nobuo</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20040415</creationdate><title>Induction of cell cycle arrest and p21(CIP1/WAF1) expression in human lung cancer cells by isoliquiritigenin</title><author>Ii, Tsunehiro ; Satomi, Yoshiko ; Katoh, Daishiro ; Shimada, Junichi ; Baba, Masaki ; Okuyama, Toru ; Nishino, Hoyoku ; Kitamura, Nobuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p207t-4898b9561174fe904e8addcbbfeec36da1544a5923e6329f42e5a003e9e020133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Cell Cycle</topic><topic>Cell Division</topic><topic>Cell Line, Tumor</topic><topic>Chalcone - analogs & derivatives</topic><topic>Chalcone - pharmacology</topic><topic>Chalcones</topic><topic>Cyclin-Dependent Kinase Inhibitor p21</topic><topic>Cyclins - biosynthesis</topic><topic>DNA, Complementary - metabolism</topic><topic>Dose-Response Relationship, Drug</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Flavonoids - pharmacology</topic><topic>Flow Cytometry</topic><topic>G2 Phase</topic><topic>Humans</topic><topic>Lung Neoplasms - drug therapy</topic><topic>Lung Neoplasms - metabolism</topic><topic>Lung Neoplasms - pathology</topic><topic>Mitosis</topic><topic>Models, Chemical</topic><topic>Nucleic Acid Hybridization</topic><topic>Oligonucleotide Array Sequence Analysis</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>RNA - metabolism</topic><topic>Time Factors</topic><topic>Up-Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ii, Tsunehiro</creatorcontrib><creatorcontrib>Satomi, Yoshiko</creatorcontrib><creatorcontrib>Katoh, Daishiro</creatorcontrib><creatorcontrib>Shimada, Junichi</creatorcontrib><creatorcontrib>Baba, Masaki</creatorcontrib><creatorcontrib>Okuyama, Toru</creatorcontrib><creatorcontrib>Nishino, Hoyoku</creatorcontrib><creatorcontrib>Kitamura, Nobuo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ii, Tsunehiro</au><au>Satomi, Yoshiko</au><au>Katoh, Daishiro</au><au>Shimada, Junichi</au><au>Baba, Masaki</au><au>Okuyama, Toru</au><au>Nishino, Hoyoku</au><au>Kitamura, Nobuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Induction of cell cycle arrest and p21(CIP1/WAF1) expression in human lung cancer cells by isoliquiritigenin</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>2004-04-15</date><risdate>2004</risdate><volume>207</volume><issue>1</issue><spage>27</spage><epage>35</epage><pages>27-35</pages><issn>0304-3835</issn><abstract>Isoliquiritigenin is a natural flavonoid isolated from licorice, shallot and bean sprouts. The effect of isoliquiritigenin on cell proliferation and cell cycle progression was examined in the A549 human lung cancer cell line. Isoliquiritigenin significantly inhibited the proliferation of lung cancer cells in a dose- and time-dependent manner. Flow cytometric analysis demonstrated that isoliquiritigenin restrained the cell cycle progression at G2/M phase. Further examinations using cDNA arrays and real-time quantitative RT-PCR revealed that isoliquiritigenin enhanced the expression of p21(CIP1/WAF1), a universal inhibitor of cyclin-dependent kinases. These results suggest that isoliquiritigenin will be a promising agent for use in chemopreventive or therapeutics against lung cancer.</abstract><cop>Ireland</cop><pmid>15050731</pmid><doi>10.1016/j.canlet.2003.10.023</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3835 |
| ispartof | Cancer letters, 2004-04, Vol.207 (1), p.27-35 |
| issn | 0304-3835 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71782142 |
| source | MEDLINE; ScienceDirect Freedom Collection (Elsevier) |
| subjects | Cell Cycle Cell Division Cell Line, Tumor Chalcone - analogs & derivatives Chalcone - pharmacology Chalcones Cyclin-Dependent Kinase Inhibitor p21 Cyclins - biosynthesis DNA, Complementary - metabolism Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacology Flavonoids - pharmacology Flow Cytometry G2 Phase Humans Lung Neoplasms - drug therapy Lung Neoplasms - metabolism Lung Neoplasms - pathology Mitosis Models, Chemical Nucleic Acid Hybridization Oligonucleotide Array Sequence Analysis Reverse Transcriptase Polymerase Chain Reaction RNA - metabolism Time Factors Up-Regulation |
| title | Induction of cell cycle arrest and p21(CIP1/WAF1) expression in human lung cancer cells by isoliquiritigenin |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T18%3A54%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Induction%20of%20cell%20cycle%20arrest%20and%20p21(CIP1/WAF1)%20expression%20in%20human%20lung%20cancer%20cells%20by%20isoliquiritigenin&rft.jtitle=Cancer%20letters&rft.au=Ii,%20Tsunehiro&rft.date=2004-04-15&rft.volume=207&rft.issue=1&rft.spage=27&rft.epage=35&rft.pages=27-35&rft.issn=0304-3835&rft_id=info:doi/10.1016/j.canlet.2003.10.023&rft_dat=%3Cproquest_pubme%3E71782142%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=71782142&rft_id=info:pmid/15050731&rfr_iscdi=true |