B7‐2 expression above a threshold elicits anti‐tumor immunity as effective as interleukin‐12 and prolongs survival in murine B‐cell lymphoma

The costimulatory molecule, B7‐2, is expressed by various lymphomas, but this level of expression is not sufficient to generate effective anti‐tumor immunity in vivo. To determine whether up‐regulated expression of the costimulatory molecule, B7‐2, leads to more effective anti‐tumor immunity in vivo...

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Veröffentlicht in:	International journal of cancer 2004-05, Vol.110 (1), p.61-69
1. Verfasser:	Pizzoferrato, Eva
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal tumors. Experimental tumors Animals Antigens, CD - physiology B7-2 Antigen B7‐2 Biological and medical sciences Cell Line, Tumor costimulatory molecules cytotoxic T lymphocytes Cytotoxicity, Immunologic Experimental malignant blood diseases Female Interleukin-12 - physiology Killer Cells, Natural - immunology Lymphoma, B-Cell - immunology Lymphoma, B-Cell - mortality Medical sciences Membrane Glycoproteins - physiology Mice Mice, Inbred BALB C Mice, Inbred C57BL natural cytotoxicity Survival Rate tumor immunity Tumors
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