Membranes as messengers in T cell adhesion signaling

Talin and RapL are components of molecular pathways that regulate the avidity of the integrin lymphocyte function–associated antigen 1 (LFA-1) for its ligand, intercellular adhesion molecule 1. In this review, we discuss recent advances in our understanding of LFA-1 affinity regulation and signaling...

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Veröffentlicht in:	Nature immunology 2004-04, Vol.5 (4), p.363-372
Hauptverfasser:	Dustin, Michael L, Bivona, Trever G, Philips, Mark R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion Animals Avidity Biomedical and Life Sciences Biomedicine Cell adhesion Cell Adhesion - physiology Cell Membrane - physiology Endosomes Golgi apparatus Humans Immunology Infectious Diseases Intercellular adhesion molecule 1 Intercellular Adhesion Molecule-1 - metabolism LFA-1 antigen Lymphocyte Function-Associated Antigen-1 - metabolism Lymphocytes Lymphocytes T Membrane trafficking Protein transport rap1 GTP-Binding Proteins - metabolism Rap1 protein review-article Signal Transduction - physiology T-Lymphocytes - physiology Talin
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