Membranes as messengers in T cell adhesion signaling
Talin and RapL are components of molecular pathways that regulate the avidity of the integrin lymphocyte function–associated antigen 1 (LFA-1) for its ligand, intercellular adhesion molecule 1. In this review, we discuss recent advances in our understanding of LFA-1 affinity regulation and signaling...
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| Veröffentlicht in: | Nature immunology 2004-04, Vol.5 (4), p.363-372 |
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| creator | Dustin, Michael L Bivona, Trever G Philips, Mark R |
| description | Talin and RapL are components of molecular pathways that regulate the avidity of the integrin lymphocyte function–associated antigen 1 (LFA-1) for its ligand, intercellular adhesion molecule 1. In this review, we discuss recent advances in our understanding of LFA-1 affinity regulation and signaling and discuss a scenario for how Talin and Rap1 might act in synergy to achieve regulation of LFA-1 that is tailored to the specific functional requirements of different situations. Speedy delivery of signals may be crucial, and membrane trafficking from endosomes and the Golgi apparatus seem to be essential in delivering the messages from spatially segregated surface receptors. |
| doi_str_mv | 10.1038/ni1057 |
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| subjects | Adhesion Animals Avidity Biomedical and Life Sciences Biomedicine Cell adhesion Cell Adhesion - physiology Cell Membrane - physiology Endosomes Golgi apparatus Humans Immunology Infectious Diseases Intercellular adhesion molecule 1 Intercellular Adhesion Molecule-1 - metabolism LFA-1 antigen Lymphocyte Function-Associated Antigen-1 - metabolism Lymphocytes Lymphocytes T Membrane trafficking Protein transport rap1 GTP-Binding Proteins - metabolism Rap1 protein review-article Signal Transduction - physiology T-Lymphocytes - physiology Talin |
| title | Membranes as messengers in T cell adhesion signaling |
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