Probing Site-Specific Energetics in Proteins and Nucleic Acids by Hydrogen Exchange and Nuclear Magnetic Resonance Spectroscopy

This chapter illustrates the use of hydrogen exchange and NMR spectroscopy to define how the free energy of stabilization of a biological molecule is being redistributed or lost as a result of a structural perturbation or of a functional change. The methodology relies on the potential of hydrogen ex...

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Veröffentlicht in:	Methods in Enzymology 2004, Vol.379, p.152-175
1. Verfasser:	Russu, Irina M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Deuterium - chemistry Deuterium Exchange Measurement - methods Hemoglobins - chemistry Histidine - chemistry Humans Hydrogen - chemistry Magnetic Resonance Spectroscopy - methods Nucleic Acids - chemistry Proteins - chemistry Tryptophan - chemistry Water - chemistry
Online-Zugang:	Volltext
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