Effective Asymmetric Synthesis of 1,2,9,9a-Tetrahydrocyclopropa[c]benzo[e]indol-4-one (CBI)

A short, asymmetric synthesis of the 1,2,9,9a-tetrahydrocyclopropa[c]benzo[e]indol-4-one (CBI) analogue of the CC-1065 and duocarmycin alkylation subunits is detailed that employs an effective enzymatic desymmetrization reaction of prochiral diol 12 using a commercially available Pseudomonas sp. lip...

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Veröffentlicht in:	Journal of organic chemistry 2004-04, Vol.69 (7), p.2284-2289
Hauptverfasser:	Kastrinsky, David B, Boger, Dale L
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylation Antibiotics, Antineoplastic - analysis Antibiotics, Antineoplastic - chemical synthesis Bioconversions. Hemisynthesis Biological and medical sciences Biotechnology Catalysis Combinatorial Chemistry Techniques Cyclopropanes - analysis Cyclopropanes - chemical synthesis Fundamental and applied biological sciences. Psychology Indoles - analysis Indoles - chemical synthesis Indoles - chemistry Lipase - metabolism Methods. Procedures. Technologies Molecular Structure Pseudomonas - enzymology Stereoisomerism
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