Odorant Stimulation Enhances Survival of Olfactory Sensory Neurons via MAPK and CREB
Olfactory sensory neurons (OSNs) can be sensitized to odorants by repeated exposure, suggesting that an animal's responsiveness to olfactory cues can be enhanced at the initial stage of detection. However, because OSNs undergo a regular cycle of apoptosis and replacement by ostensibly naive, pr...
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| Veröffentlicht in: | Neuron (Cambridge, Mass.) Mass.), 2004-03, Vol.41 (6), p.955-967 |
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| creator | Watt, William C Sakano, Hitomi Lee, Zong-Yi Reusch, Jane E Trinh, Kien Storm, Daniel R |
| description | Olfactory sensory neurons (OSNs) can be sensitized to odorants by repeated exposure, suggesting that an animal's responsiveness to olfactory cues can be enhanced at the initial stage of detection. However, because OSNs undergo a regular cycle of apoptosis and replacement by ostensibly naive, precursor-derived neurons, the advantage of sensitization would be lost in the absence of a mechanism for odorant-enhanced survival of OSNs. Using recombinant adenoviruses in conjunction with surgical and electrophysiological techniques, we monitored OSN survival and function in vivo and find that odorant exposure selectively rescues populations of OSNs from apoptosis. We further demonstrate that odorant stimuli rescue OSNs in a cAMP-dependent manner by activating the MAPK/CREB-dependent transcriptional pathway, possibly as a result of expression of Bcl-2. |
| doi_str_mv | 10.1016/S0896-6273(04)00075-3 |
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However, because OSNs undergo a regular cycle of apoptosis and replacement by ostensibly naive, precursor-derived neurons, the advantage of sensitization would be lost in the absence of a mechanism for odorant-enhanced survival of OSNs. Using recombinant adenoviruses in conjunction with surgical and electrophysiological techniques, we monitored OSN survival and function in vivo and find that odorant exposure selectively rescues populations of OSNs from apoptosis. 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| subjects | Animals Apoptosis - genetics Cell Line Cell Membrane - genetics Cell Membrane - metabolism Cell Survival - genetics Cyclic AMP Response Element-Binding Protein - metabolism Genetic Vectors - genetics Humans Kinases MAP Kinase Signaling System - physiology Membrane Potentials - genetics Mice Mice, Inbred C57BL Microscopy Neurons Neurons, Afferent - cytology Neurons, Afferent - enzymology Olfactory Mucosa - cytology Olfactory Mucosa - enzymology Potassium Proto-Oncogene Proteins c-bcl-2 - genetics Receptors, Odorant - genetics Receptors, Odorant - metabolism Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Signal transduction Smell - physiology Surgery |
| title | Odorant Stimulation Enhances Survival of Olfactory Sensory Neurons via MAPK and CREB |
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