Fluorescence Properties and Metabolic Features of Indocyanine Green (ICG) as Related to Angiography
Indocyanine green (ICG) is a fluorescent dye that has been used for the imaging of retinal and choroidal vasculatures for more than 30 years. Its high molecular weight, specific metabolic features, and its infrared spectra make the specificity of the images obtained with this dye in ophthalmology. T...
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| Veröffentlicht in: | Survey of ophthalmology 2000-07, Vol.45 (1), p.15-27 |
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| description | Indocyanine green (ICG) is a fluorescent dye that has been used for the imaging of retinal and choroidal vasculatures for more than 30 years. Its high molecular weight, specific metabolic features, and its infrared spectra make the specificity of the images obtained with this dye in ophthalmology. The focus of this paper is to review the basic properties of ICG and to show how some clinical features related to basic properties also depend on the instrumentation used to perform ICG angiography. Indocyanine green has a complex molecular structure that leads to amphiphilic properties, that is, both hydrophilic and lipophilic properties. These properties explain that a specific interaction with phospholipids influences the emission spectrum and the fluorescence yield of ICG. The composition of cell membranes mainly composed of phospholipid bilayers is consistent with a binding and/or a diffusion of ICG molecules observed on angiograms. Likewise, ICG can bind to the lipid component of miliary drusen, explaining their hyperfluorescence. A knowledge of ICG basic properties and interactions may allow a better understanding of angiograms performed with this dye. |
| doi_str_mv | 10.1016/S0039-6257(00)00123-5 |
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Its high molecular weight, specific metabolic features, and its infrared spectra make the specificity of the images obtained with this dye in ophthalmology. The focus of this paper is to review the basic properties of ICG and to show how some clinical features related to basic properties also depend on the instrumentation used to perform ICG angiography. Indocyanine green has a complex molecular structure that leads to amphiphilic properties, that is, both hydrophilic and lipophilic properties. These properties explain that a specific interaction with phospholipids influences the emission spectrum and the fluorescence yield of ICG. The composition of cell membranes mainly composed of phospholipid bilayers is consistent with a binding and/or a diffusion of ICG molecules observed on angiograms. Likewise, ICG can bind to the lipid component of miliary drusen, explaining their hyperfluorescence. A knowledge of ICG basic properties and interactions may allow a better understanding of angiograms performed with this dye.</description><identifier>ISSN: 0039-6257</identifier><identifier>EISSN: 1879-3304</identifier><identifier>DOI: 10.1016/S0039-6257(00)00123-5</identifier><identifier>PMID: 10946079</identifier><identifier>CODEN: SUOPAD</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Absorption ; age-related macular degeneration ; angiography ; Binding Sites ; Biological and medical sciences ; choroidal neovascularization ; Contrast Media - chemistry ; Contrast Media - pharmacokinetics ; fluorescein ; Fluorescein - chemistry ; Fluorescein - pharmacokinetics ; Fluorescein Angiography - instrumentation ; Fluorescence ; Fluorescent Dyes - chemistry ; Fluorescent Dyes - pharmacokinetics ; Fundus Oculi ; Humans ; ICG ; indocyanine green ; Indocyanine Green - chemistry ; Indocyanine Green - pharmacokinetics ; Investigative techniques, diagnostic techniques (general aspects) ; Light ; Medical sciences ; Molecular Structure ; Otorhinolaryngology. Stomatology. Orbit ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; Retinal Diseases - diagnosis ; Retinal Diseases - metabolism</subject><ispartof>Survey of ophthalmology, 2000-07, Vol.45 (1), p.15-27</ispartof><rights>2000 Elsevier Science Inc.</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c508t-b996b9926715ba5e75539bc3401532bb9256a9afe8ee5ee3f4d30bc1a433ecb03</citedby><cites>FETCH-LOGICAL-c508t-b996b9926715ba5e75539bc3401532bb9256a9afe8ee5ee3f4d30bc1a433ecb03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0039-6257(00)00123-5$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1503164$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10946079$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Desmettre, T</creatorcontrib><creatorcontrib>Devoisselle, J.M</creatorcontrib><creatorcontrib>Mordon, S</creatorcontrib><title>Fluorescence Properties and Metabolic Features of Indocyanine Green (ICG) as Related to Angiography</title><title>Survey of ophthalmology</title><addtitle>Surv Ophthalmol</addtitle><description>Indocyanine green (ICG) is a fluorescent dye that has been used for the imaging of retinal and choroidal vasculatures for more than 30 years. Its high molecular weight, specific metabolic features, and its infrared spectra make the specificity of the images obtained with this dye in ophthalmology. The focus of this paper is to review the basic properties of ICG and to show how some clinical features related to basic properties also depend on the instrumentation used to perform ICG angiography. Indocyanine green has a complex molecular structure that leads to amphiphilic properties, that is, both hydrophilic and lipophilic properties. These properties explain that a specific interaction with phospholipids influences the emission spectrum and the fluorescence yield of ICG. The composition of cell membranes mainly composed of phospholipid bilayers is consistent with a binding and/or a diffusion of ICG molecules observed on angiograms. Likewise, ICG can bind to the lipid component of miliary drusen, explaining their hyperfluorescence. A knowledge of ICG basic properties and interactions may allow a better understanding of angiograms performed with this dye.</description><subject>Absorption</subject><subject>age-related macular degeneration</subject><subject>angiography</subject><subject>Binding Sites</subject><subject>Biological and medical sciences</subject><subject>choroidal neovascularization</subject><subject>Contrast Media - chemistry</subject><subject>Contrast Media - pharmacokinetics</subject><subject>fluorescein</subject><subject>Fluorescein - chemistry</subject><subject>Fluorescein - pharmacokinetics</subject><subject>Fluorescein Angiography - instrumentation</subject><subject>Fluorescence</subject><subject>Fluorescent Dyes - chemistry</subject><subject>Fluorescent Dyes - pharmacokinetics</subject><subject>Fundus Oculi</subject><subject>Humans</subject><subject>ICG</subject><subject>indocyanine green</subject><subject>Indocyanine Green - chemistry</subject><subject>Indocyanine Green - pharmacokinetics</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Light</subject><subject>Medical sciences</subject><subject>Molecular Structure</subject><subject>Otorhinolaryngology. Stomatology. Orbit</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>Retinal Diseases - diagnosis</subject><subject>Retinal Diseases - metabolism</subject><issn>0039-6257</issn><issn>1879-3304</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUuP0zAQgC0EYsvCTwD5gNDuITCO47g-oVVFS6VFIB5na-xMFqPULnaC1H9Puq2AG4fRXL55fcPYcwGvBYj2zRcAaaq2VvoK4BpA1LJSD9hCLLWppITmIVv8QS7Yk1J-AEAjjX7MLgSYpgVtFsyvhyllKp6iJ_4ppz3lMVDhGDv-gUZ0aQierwnHacZ46vk2dskfMIZIfJOJIr_arjbXHAv_TAOO1PEx8Zt4F9Jdxv33w1P2qMeh0LNzvmTf1u--rt5Xtx8329XNbeUVLMfKGdPOUbdaKIeKtFLSOC8bEErWzplatWiwpyWRIpJ900lwXmAjJXkH8pK9OvXd5_RzojLaXZgPGwaMlKZitdDayNbMoDqBPqdSMvV2n8MO88EKsEe79t6uPaqzAPberlVz3YvzgMntqPun6qRzBl6eASwehz5j9KH85RRI0TYz9vaE0WzjV6Bsiw_HB3Qhkx9tl8J_NvkNJVCV6Q</recordid><startdate>20000701</startdate><enddate>20000701</enddate><creator>Desmettre, T</creator><creator>Devoisselle, J.M</creator><creator>Mordon, S</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000701</creationdate><title>Fluorescence Properties and Metabolic Features of Indocyanine Green (ICG) as Related to Angiography</title><author>Desmettre, T ; Devoisselle, J.M ; Mordon, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c508t-b996b9926715ba5e75539bc3401532bb9256a9afe8ee5ee3f4d30bc1a433ecb03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Absorption</topic><topic>age-related macular degeneration</topic><topic>angiography</topic><topic>Binding Sites</topic><topic>Biological and medical sciences</topic><topic>choroidal neovascularization</topic><topic>Contrast Media - chemistry</topic><topic>Contrast Media - pharmacokinetics</topic><topic>fluorescein</topic><topic>Fluorescein - chemistry</topic><topic>Fluorescein - pharmacokinetics</topic><topic>Fluorescein Angiography - instrumentation</topic><topic>Fluorescence</topic><topic>Fluorescent Dyes - chemistry</topic><topic>Fluorescent Dyes - pharmacokinetics</topic><topic>Fundus Oculi</topic><topic>Humans</topic><topic>ICG</topic><topic>indocyanine green</topic><topic>Indocyanine Green - chemistry</topic><topic>Indocyanine Green - pharmacokinetics</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Light</topic><topic>Medical sciences</topic><topic>Molecular Structure</topic><topic>Otorhinolaryngology. Stomatology. Orbit</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>Retinal Diseases - diagnosis</topic><topic>Retinal Diseases - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Desmettre, T</creatorcontrib><creatorcontrib>Devoisselle, J.M</creatorcontrib><creatorcontrib>Mordon, S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Survey of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Desmettre, T</au><au>Devoisselle, J.M</au><au>Mordon, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fluorescence Properties and Metabolic Features of Indocyanine Green (ICG) as Related to Angiography</atitle><jtitle>Survey of ophthalmology</jtitle><addtitle>Surv Ophthalmol</addtitle><date>2000-07-01</date><risdate>2000</risdate><volume>45</volume><issue>1</issue><spage>15</spage><epage>27</epage><pages>15-27</pages><issn>0039-6257</issn><eissn>1879-3304</eissn><coden>SUOPAD</coden><abstract>Indocyanine green (ICG) is a fluorescent dye that has been used for the imaging of retinal and choroidal vasculatures for more than 30 years. Its high molecular weight, specific metabolic features, and its infrared spectra make the specificity of the images obtained with this dye in ophthalmology. The focus of this paper is to review the basic properties of ICG and to show how some clinical features related to basic properties also depend on the instrumentation used to perform ICG angiography. Indocyanine green has a complex molecular structure that leads to amphiphilic properties, that is, both hydrophilic and lipophilic properties. These properties explain that a specific interaction with phospholipids influences the emission spectrum and the fluorescence yield of ICG. The composition of cell membranes mainly composed of phospholipid bilayers is consistent with a binding and/or a diffusion of ICG molecules observed on angiograms. Likewise, ICG can bind to the lipid component of miliary drusen, explaining their hyperfluorescence. A knowledge of ICG basic properties and interactions may allow a better understanding of angiograms performed with this dye.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>10946079</pmid><doi>10.1016/S0039-6257(00)00123-5</doi><tpages>13</tpages></addata></record> |
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| subjects | Absorption age-related macular degeneration angiography Binding Sites Biological and medical sciences choroidal neovascularization Contrast Media - chemistry Contrast Media - pharmacokinetics fluorescein Fluorescein - chemistry Fluorescein - pharmacokinetics Fluorescein Angiography - instrumentation Fluorescence Fluorescent Dyes - chemistry Fluorescent Dyes - pharmacokinetics Fundus Oculi Humans ICG indocyanine green Indocyanine Green - chemistry Indocyanine Green - pharmacokinetics Investigative techniques, diagnostic techniques (general aspects) Light Medical sciences Molecular Structure Otorhinolaryngology. Stomatology. Orbit Radiodiagnosis. Nmr imagery. Nmr spectrometry Retinal Diseases - diagnosis Retinal Diseases - metabolism |
| title | Fluorescence Properties and Metabolic Features of Indocyanine Green (ICG) as Related to Angiography |
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