Acute graft-versus-host disease does not require alloantigen expression on host epithelium
Alloantigen expression on host antigen-presenting cells (APCs) is essential to initiate graft-versus-host disease (GvHD); therefore, alloantigen expression on host target epithelium is also thought to be essential for tissue damage. We tested this hypothesis in mouse models of GvHD using bone-marrow...
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| Veröffentlicht in: | Nature medicine 2002-06, Vol.8 (6), p.575-581 |
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| creator | Ferrara, James L. M Teshima, Takanori Ordemann, Rainer Reddy, Pavan Gagin, Svetlana Liu, Chen Cooke, Kenneth R |
| description | Alloantigen expression on host antigen-presenting cells (APCs) is essential to initiate graft-versus-host disease (GvHD); therefore, alloantigen expression on host target epithelium is also thought to be essential for tissue damage. We tested this hypothesis in mouse models of GvHD using bone-marrow chimeras in which either major histocompatibility complex class I or class II alloantigen was expressed only on APCs. We found that acute GvHD does not require alloantigen expression on host target epithelium and that neutralization of tumor necrosis factor-α and interleukin-1 prevents acute GvHD. These results pertain particularly to CD4-mediated GvHD but also apply, at least in part, to CD8-mediated GvHD. These results challenge current paradigms about the antigen specificity of GvHD effector mechanisms and confirm the central roles of both host APCs and inflammatory cytokines in acute GvHD. |
| doi_str_mv | 10.1038/nm0602-575 |
| format | Article |
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These results challenge current paradigms about the antigen specificity of GvHD effector mechanisms and confirm the central roles of both host APCs and inflammatory cytokines in acute GvHD.</description><identifier>ISSN: 1078-8956</identifier><identifier>EISSN: 1546-170X</identifier><identifier>DOI: 10.1038/nm0602-575</identifier><identifier>PMID: 12042807</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Acute Disease ; Analysis ; Animals ; Antigen-Presenting Cells - immunology ; Biomedical and Life Sciences ; Biomedicine ; Bone marrow ; Bone Marrow Transplantation - immunology ; Bone Marrow Transplantation - pathology ; Cancer Research ; Epithelium ; Epithelium - immunology ; Female ; Graft vs Host Disease - immunology ; Graft vs Host Disease - pathology ; Graft vs Host Disease - prevention & control ; Histocompatibility Antigens Class II - immunology ; Infectious Diseases ; Interleukin-1 - immunology ; Isoantigens - immunology ; Metabolic Diseases ; Mice ; Mice, Inbred C57BL ; Molecular Medicine ; Neurosciences ; Neutralization ; Transplantation Chimera ; Tumor necrosis factor ; Tumor Necrosis Factor-alpha - immunology</subject><ispartof>Nature medicine, 2002-06, Vol.8 (6), p.575-581</ispartof><rights>Springer Nature America, Inc. 2002</rights><rights>COPYRIGHT 2002 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jun 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c547t-72b20693151a09592fcccf801276fccf7a63838afd3b76b932235cdfaceb30a63</citedby><cites>FETCH-LOGICAL-c547t-72b20693151a09592fcccf801276fccf7a63838afd3b76b932235cdfaceb30a63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/nm0602-575$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/nm0602-575$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,2725,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12042807$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ferrara, James L. 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We tested this hypothesis in mouse models of GvHD using bone-marrow chimeras in which either major histocompatibility complex class I or class II alloantigen was expressed only on APCs. We found that acute GvHD does not require alloantigen expression on host target epithelium and that neutralization of tumor necrosis factor-α and interleukin-1 prevents acute GvHD. These results pertain particularly to CD4-mediated GvHD but also apply, at least in part, to CD8-mediated GvHD. These results challenge current paradigms about the antigen specificity of GvHD effector mechanisms and confirm the central roles of both host APCs and inflammatory cytokines in acute GvHD.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>12042807</pmid><doi>10.1038/nm0602-575</doi><tpages>7</tpages></addata></record> |
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| ispartof | Nature medicine, 2002-06, Vol.8 (6), p.575-581 |
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| subjects | Acute Disease Analysis Animals Antigen-Presenting Cells - immunology Biomedical and Life Sciences Biomedicine Bone marrow Bone Marrow Transplantation - immunology Bone Marrow Transplantation - pathology Cancer Research Epithelium Epithelium - immunology Female Graft vs Host Disease - immunology Graft vs Host Disease - pathology Graft vs Host Disease - prevention & control Histocompatibility Antigens Class II - immunology Infectious Diseases Interleukin-1 - immunology Isoantigens - immunology Metabolic Diseases Mice Mice, Inbred C57BL Molecular Medicine Neurosciences Neutralization Transplantation Chimera Tumor necrosis factor Tumor Necrosis Factor-alpha - immunology |
| title | Acute graft-versus-host disease does not require alloantigen expression on host epithelium |
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