Cervical regeneration after diathermy excision of cervical intraepithelial neoplasia as assessed by transvaginal sonography
Objective: To evaluate regeneration in cervical craters following large loop excision of the transformation zone (LLETZ) and to investigate possible differential healing patterns depending on the cone’s size. Study design: A prospective study of 100 nulliparous women who underwent LLETZ. They underw...
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| Veröffentlicht in: | European journal of obstetrics & gynecology and reproductive biology 2002-04, Vol.102 (1), p.88-91 |
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| container_title | European journal of obstetrics & gynecology and reproductive biology |
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| creator | Paraskevaidis, Evangelos Bilirakis, Evripidis Koliopoulos, George Lolis, Evangelos D Kalantaridou, Sofia Paschopoulos, Minas Plachouras, Nicholas Malamou-Mitsi, Vasiliki Kitchener, Henry C |
| description | Objective: To evaluate regeneration in cervical craters following large loop excision of the transformation zone (LLETZ) and to investigate possible differential healing patterns depending on the cone’s size.
Study design: A prospective study of 100 nulliparous women who underwent LLETZ. They underwent transvaginal scanning estimation of the cervical craters (diameter, depth) immediately post-operatively and at 3, 6 and 12 months. The crater dimensions of the women with the 25 largest cones were compared to those of the women with the 25 smallest cones in each of the above points of time.
Results: The mean crater size of all women at 12 months was significantly smaller from the crater size immediately post-operatively. Although, there was a statistically significant difference in mean crater dimensions between the two quartile groups immediately post-operatively, no difference was found at 6 and 12 months.
Conclusion: There is a healing process of the cervical crater, which is almost completed by the sixth post-treatment month. The defect remaining in the cervix is similar whether a large or small excision was performed. |
| doi_str_mv | 10.1016/S0301-2115(01)00574-7 |
| format | Article |
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Study design: A prospective study of 100 nulliparous women who underwent LLETZ. They underwent transvaginal scanning estimation of the cervical craters (diameter, depth) immediately post-operatively and at 3, 6 and 12 months. The crater dimensions of the women with the 25 largest cones were compared to those of the women with the 25 smallest cones in each of the above points of time.
Results: The mean crater size of all women at 12 months was significantly smaller from the crater size immediately post-operatively. Although, there was a statistically significant difference in mean crater dimensions between the two quartile groups immediately post-operatively, no difference was found at 6 and 12 months.
Conclusion: There is a healing process of the cervical crater, which is almost completed by the sixth post-treatment month. The defect remaining in the cervix is similar whether a large or small excision was performed.</description><identifier>ISSN: 0301-2115</identifier><identifier>EISSN: 1872-7654</identifier><identifier>DOI: 10.1016/S0301-2115(01)00574-7</identifier><identifier>PMID: 12039097</identifier><identifier>CODEN: EOGRAL</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Adult ; Biological and medical sciences ; Cervical Intraepithelial Neoplasia - physiopathology ; Cervical Intraepithelial Neoplasia - surgery ; Cervix Uteri - blood supply ; Cervix Uteri - diagnostic imaging ; Cervix Uteri - physiopathology ; Electrocoagulation ; Female ; Female genital diseases ; Gynecology. Andrology. Obstetrics ; Humans ; LLETZ ; Medical sciences ; Prospective Studies ; Regeneration ; Tumors ; Ultrasonography ; Ultrasound ; Uterine cervix</subject><ispartof>European journal of obstetrics & gynecology and reproductive biology, 2002-04, Vol.102 (1), p.88-91</ispartof><rights>2002 Elsevier Science Ireland Ltd</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-fbc2b3c8310c23bad1c0e08fcd316f94606e705d4c51a004472a7655810b24f63</citedby><cites>FETCH-LOGICAL-c391t-fbc2b3c8310c23bad1c0e08fcd316f94606e705d4c51a004472a7655810b24f63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0301211501005747$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13576621$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12039097$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Paraskevaidis, Evangelos</creatorcontrib><creatorcontrib>Bilirakis, Evripidis</creatorcontrib><creatorcontrib>Koliopoulos, George</creatorcontrib><creatorcontrib>Lolis, Evangelos D</creatorcontrib><creatorcontrib>Kalantaridou, Sofia</creatorcontrib><creatorcontrib>Paschopoulos, Minas</creatorcontrib><creatorcontrib>Plachouras, Nicholas</creatorcontrib><creatorcontrib>Malamou-Mitsi, Vasiliki</creatorcontrib><creatorcontrib>Kitchener, Henry C</creatorcontrib><title>Cervical regeneration after diathermy excision of cervical intraepithelial neoplasia as assessed by transvaginal sonography</title><title>European journal of obstetrics & gynecology and reproductive biology</title><addtitle>Eur J Obstet Gynecol Reprod Biol</addtitle><description>Objective: To evaluate regeneration in cervical craters following large loop excision of the transformation zone (LLETZ) and to investigate possible differential healing patterns depending on the cone’s size.
Study design: A prospective study of 100 nulliparous women who underwent LLETZ. They underwent transvaginal scanning estimation of the cervical craters (diameter, depth) immediately post-operatively and at 3, 6 and 12 months. The crater dimensions of the women with the 25 largest cones were compared to those of the women with the 25 smallest cones in each of the above points of time.
Results: The mean crater size of all women at 12 months was significantly smaller from the crater size immediately post-operatively. Although, there was a statistically significant difference in mean crater dimensions between the two quartile groups immediately post-operatively, no difference was found at 6 and 12 months.
Conclusion: There is a healing process of the cervical crater, which is almost completed by the sixth post-treatment month. The defect remaining in the cervix is similar whether a large or small excision was performed.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cervical Intraepithelial Neoplasia - physiopathology</subject><subject>Cervical Intraepithelial Neoplasia - surgery</subject><subject>Cervix Uteri - blood supply</subject><subject>Cervix Uteri - diagnostic imaging</subject><subject>Cervix Uteri - physiopathology</subject><subject>Electrocoagulation</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>LLETZ</subject><subject>Medical sciences</subject><subject>Prospective Studies</subject><subject>Regeneration</subject><subject>Tumors</subject><subject>Ultrasonography</subject><subject>Ultrasound</subject><subject>Uterine cervix</subject><issn>0301-2115</issn><issn>1872-7654</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFu1DAQhi1URLeFR6DKpQgOgZk4sZNTVa0oIFXiAJwtxxlvXWWT1M6uWPHyzHaX9og10sjy949HnxBvET4ioPr0AyRgXiBW7wE_AFS6zPULscBaF7lWVXkiFk_IqThL6R74SNm8EqdYgGyg0QvxZ0lxG5zts0grGijaOYxDZv1MMeuCne8orncZ_XYh7R9Gn7l_iTDM0dIUmOkD3wcap96mYDObuBJxdVm7yxgb0tauwsBUGodxFe10t3stXnrbJ3pz7Ofi183nn8uv-e33L9-W17e5kw3OuW9d0UpXSwRXyNZ26ICg9q6TqHxTKlCkoepKV6EFKEtdWBZQ1QhtUXolz8W7w9wpjg8bSrNZh-So7y1vvElGo9a1QslgdQBdHFOK5M0Uw9rGnUEwe-vm0brZKzXcH60bzbmL4webdk3dc-qomYHLI2ATm_Psg30-c7LSShXI3NWBI9axDRRNcoEGR12I5GbTjeE_q_wFKVSg8w</recordid><startdate>20020410</startdate><enddate>20020410</enddate><creator>Paraskevaidis, Evangelos</creator><creator>Bilirakis, Evripidis</creator><creator>Koliopoulos, George</creator><creator>Lolis, Evangelos D</creator><creator>Kalantaridou, Sofia</creator><creator>Paschopoulos, Minas</creator><creator>Plachouras, Nicholas</creator><creator>Malamou-Mitsi, Vasiliki</creator><creator>Kitchener, Henry C</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020410</creationdate><title>Cervical regeneration after diathermy excision of cervical intraepithelial neoplasia as assessed by transvaginal sonography</title><author>Paraskevaidis, Evangelos ; Bilirakis, Evripidis ; Koliopoulos, George ; Lolis, Evangelos D ; Kalantaridou, Sofia ; Paschopoulos, Minas ; Plachouras, Nicholas ; Malamou-Mitsi, Vasiliki ; Kitchener, Henry C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-fbc2b3c8310c23bad1c0e08fcd316f94606e705d4c51a004472a7655810b24f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Cervical Intraepithelial Neoplasia - physiopathology</topic><topic>Cervical Intraepithelial Neoplasia - surgery</topic><topic>Cervix Uteri - blood supply</topic><topic>Cervix Uteri - diagnostic imaging</topic><topic>Cervix Uteri - physiopathology</topic><topic>Electrocoagulation</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>LLETZ</topic><topic>Medical sciences</topic><topic>Prospective Studies</topic><topic>Regeneration</topic><topic>Tumors</topic><topic>Ultrasonography</topic><topic>Ultrasound</topic><topic>Uterine cervix</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Paraskevaidis, Evangelos</creatorcontrib><creatorcontrib>Bilirakis, Evripidis</creatorcontrib><creatorcontrib>Koliopoulos, George</creatorcontrib><creatorcontrib>Lolis, Evangelos D</creatorcontrib><creatorcontrib>Kalantaridou, Sofia</creatorcontrib><creatorcontrib>Paschopoulos, Minas</creatorcontrib><creatorcontrib>Plachouras, Nicholas</creatorcontrib><creatorcontrib>Malamou-Mitsi, Vasiliki</creatorcontrib><creatorcontrib>Kitchener, Henry C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of obstetrics & gynecology and reproductive biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Paraskevaidis, Evangelos</au><au>Bilirakis, Evripidis</au><au>Koliopoulos, George</au><au>Lolis, Evangelos D</au><au>Kalantaridou, Sofia</au><au>Paschopoulos, Minas</au><au>Plachouras, Nicholas</au><au>Malamou-Mitsi, Vasiliki</au><au>Kitchener, Henry C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cervical regeneration after diathermy excision of cervical intraepithelial neoplasia as assessed by transvaginal sonography</atitle><jtitle>European journal of obstetrics & gynecology and reproductive biology</jtitle><addtitle>Eur J Obstet Gynecol Reprod Biol</addtitle><date>2002-04-10</date><risdate>2002</risdate><volume>102</volume><issue>1</issue><spage>88</spage><epage>91</epage><pages>88-91</pages><issn>0301-2115</issn><eissn>1872-7654</eissn><coden>EOGRAL</coden><abstract>Objective: To evaluate regeneration in cervical craters following large loop excision of the transformation zone (LLETZ) and to investigate possible differential healing patterns depending on the cone’s size.
Study design: A prospective study of 100 nulliparous women who underwent LLETZ. They underwent transvaginal scanning estimation of the cervical craters (diameter, depth) immediately post-operatively and at 3, 6 and 12 months. The crater dimensions of the women with the 25 largest cones were compared to those of the women with the 25 smallest cones in each of the above points of time.
Results: The mean crater size of all women at 12 months was significantly smaller from the crater size immediately post-operatively. Although, there was a statistically significant difference in mean crater dimensions between the two quartile groups immediately post-operatively, no difference was found at 6 and 12 months.
Conclusion: There is a healing process of the cervical crater, which is almost completed by the sixth post-treatment month. The defect remaining in the cervix is similar whether a large or small excision was performed.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>12039097</pmid><doi>10.1016/S0301-2115(01)00574-7</doi><tpages>4</tpages></addata></record> |
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| ispartof | European journal of obstetrics & gynecology and reproductive biology, 2002-04, Vol.102 (1), p.88-91 |
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| subjects | Adult Biological and medical sciences Cervical Intraepithelial Neoplasia - physiopathology Cervical Intraepithelial Neoplasia - surgery Cervix Uteri - blood supply Cervix Uteri - diagnostic imaging Cervix Uteri - physiopathology Electrocoagulation Female Female genital diseases Gynecology. Andrology. Obstetrics Humans LLETZ Medical sciences Prospective Studies Regeneration Tumors Ultrasonography Ultrasound Uterine cervix |
| title | Cervical regeneration after diathermy excision of cervical intraepithelial neoplasia as assessed by transvaginal sonography |
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