Analysis of two acidic P6 pocket residues in the pH dependency of peptide binding by I-E(k)

Peptide binding to major histocompatibility complex (MHC) class II molecules is optimal at mildly acidic pH. X-ray crystal structures solved for the murine class II molecule I-E(k) revealed an interesting localization of negatively charged residues within the P6 pocket, which may have implications i...

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Veröffentlicht in:	Molecular immunology 2002-06, Vol.38 (15), p.1139-1149
Hauptverfasser:	Dao, Chinh T, Weber, Dominique A, Jensen, Peter E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aspartic Acid - metabolism Glutamic Acid - metabolism Histocompatibility Antigens Class II - genetics Histocompatibility Antigens Class II - metabolism HLA-D Antigens - metabolism Humans Hydrogen-Ion Concentration Mice Mutation Peptides - metabolism Protein Conformation
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