Atypical squamous cells of undetermined significance in girls and women
To estimate the outcome of adolescents with atypical squamous cells of undetermined significance (ASC-US) on cytology. A review of ASC-US cytology in girls and women aged 10-19 years between 1995 and 1999 was performed. The cytologic and histologic follow-up of each patient was evaluated. The outcom...
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| Veröffentlicht in: | Obstetrics and gynecology (New York. 1953) 2004-04, Vol.103 (4), p.632-638 |
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| container_title | Obstetrics and gynecology (New York. 1953) |
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| creator | WRIGHT, Jason D PINTO, Anil B POWELL, Matthew A LU, Danielle W FENG GAO PINTO, Karen R |
| description | To estimate the outcome of adolescents with atypical squamous cells of undetermined significance (ASC-US) on cytology.
A review of ASC-US cytology in girls and women aged 10-19 years between 1995 and 1999 was performed. The cytologic and histologic follow-up of each patient was evaluated. The outcome was recorded as the most significant (highest grade) subsequent cervical smear or biopsy.
Overall, 535 of 7897 (6.8%) cervical cytologic specimens were reported as ASC-US. The study group consisted of 398 patients for whom pathologic follow-up was available. The mean duration of follow-up was 19 months. Follow-up consisted of repeat cytology in 251 (63%) patients and colposcopy with cervical biopsies and/or endocervical curettage in 147 (37%) of the adolescents. Two hundred fifty-three (64%) adolescents had no pathologic abnormalities on follow-up. Persistent ASC-US was identified in 65 (16%), low-grade squamous intraepithelial lesions/cervical intraepithelial neoplasia (CIN) 1 was found in 44 (11%) and high-grade squamous intraepithelial lesions/CIN 2 or 3 occurred in 36 (9%) of the adolescents. No cases of invasive carcinoma were found.
Among adolescents with ASC-US, the rate of squamous intraepithelial lesions/CIN is similar to that of adults. Although the optimal management of ASC-US in adolescents is unknown, these patients warrant close follow-up.
III |
| doi_str_mv | 10.1097/01.AOG.0000120145.85419.c4 |
| format | Article |
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A review of ASC-US cytology in girls and women aged 10-19 years between 1995 and 1999 was performed. The cytologic and histologic follow-up of each patient was evaluated. The outcome was recorded as the most significant (highest grade) subsequent cervical smear or biopsy.
Overall, 535 of 7897 (6.8%) cervical cytologic specimens were reported as ASC-US. The study group consisted of 398 patients for whom pathologic follow-up was available. The mean duration of follow-up was 19 months. Follow-up consisted of repeat cytology in 251 (63%) patients and colposcopy with cervical biopsies and/or endocervical curettage in 147 (37%) of the adolescents. Two hundred fifty-three (64%) adolescents had no pathologic abnormalities on follow-up. Persistent ASC-US was identified in 65 (16%), low-grade squamous intraepithelial lesions/cervical intraepithelial neoplasia (CIN) 1 was found in 44 (11%) and high-grade squamous intraepithelial lesions/CIN 2 or 3 occurred in 36 (9%) of the adolescents. No cases of invasive carcinoma were found.
Among adolescents with ASC-US, the rate of squamous intraepithelial lesions/CIN is similar to that of adults. Although the optimal management of ASC-US in adolescents is unknown, these patients warrant close follow-up.
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A review of ASC-US cytology in girls and women aged 10-19 years between 1995 and 1999 was performed. The cytologic and histologic follow-up of each patient was evaluated. The outcome was recorded as the most significant (highest grade) subsequent cervical smear or biopsy.
Overall, 535 of 7897 (6.8%) cervical cytologic specimens were reported as ASC-US. The study group consisted of 398 patients for whom pathologic follow-up was available. The mean duration of follow-up was 19 months. Follow-up consisted of repeat cytology in 251 (63%) patients and colposcopy with cervical biopsies and/or endocervical curettage in 147 (37%) of the adolescents. Two hundred fifty-three (64%) adolescents had no pathologic abnormalities on follow-up. Persistent ASC-US was identified in 65 (16%), low-grade squamous intraepithelial lesions/cervical intraepithelial neoplasia (CIN) 1 was found in 44 (11%) and high-grade squamous intraepithelial lesions/CIN 2 or 3 occurred in 36 (9%) of the adolescents. No cases of invasive carcinoma were found.
Among adolescents with ASC-US, the rate of squamous intraepithelial lesions/CIN is similar to that of adults. Although the optimal management of ASC-US in adolescents is unknown, these patients warrant close follow-up.
III</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Biological and medical sciences</subject><subject>Cervical Intraepithelial Neoplasia - pathology</subject><subject>Cervix Uteri - pathology</subject><subject>Child</subject><subject>Disease Progression</subject><subject>Epithelial Cells - pathology</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Follow-Up Studies</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Neoplasms, Squamous Cell - pathology</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Time Factors</subject><subject>Tumors</subject><subject>Uterine Cervical Neoplasms - pathology</subject><subject>Vaginal Smears</subject><issn>0029-7844</issn><issn>1873-233X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkE1Lw0AQhhdRbK3-BQmC3hL3I5vpeitFq1DoRcHbstnMlpUmabMN0n_vVgN1LnN53neGh5A7RjNGFTxSls1Wi4zGYZyyXGZTmTOV2fyMjNkURMqF-DwnY0q5SmGa5yNyFcLXkS-UuCQjJqlkUrIxWcz2h623ZpOEXW_qtg-Jxc0mJK1L-qbCPXa1b7BKgl833kWysZj4Jln7LlKmqZLvtsbmmlw4swl4M-wJ-Xh5fp-_psvV4m0-W6ZWKNinUFhkMpcATGGBElyF1pVU8BId52BooSTllbKWCnQOLDW8MlCVgAqFFBPy8Ne77dpdj2Gvax-OH5sG4_MaGMRunkfw6Q-0XRtCh05vO1-b7qAZ1UeNmjIdNeqTRv2rUdtj-Ha40pc1Vqfo4C0C9wNgQpTnuqjFh39ckcMUQPwAGHR8gw</recordid><startdate>20040401</startdate><enddate>20040401</enddate><creator>WRIGHT, Jason D</creator><creator>PINTO, Anil B</creator><creator>POWELL, Matthew A</creator><creator>LU, Danielle W</creator><creator>FENG GAO</creator><creator>PINTO, Karen R</creator><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040401</creationdate><title>Atypical squamous cells of undetermined significance in girls and women</title><author>WRIGHT, Jason D ; PINTO, Anil B ; POWELL, Matthew A ; LU, Danielle W ; FENG GAO ; PINTO, Karen R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c397t-76ce15457719e6e57fdecfb032bef227a069502d9cc03eff7c0a2da7db7e9e353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Biological and medical sciences</topic><topic>Cervical Intraepithelial Neoplasia - pathology</topic><topic>Cervix Uteri - pathology</topic><topic>Child</topic><topic>Disease Progression</topic><topic>Epithelial Cells - pathology</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Follow-Up Studies</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Neoplasms, Squamous Cell - pathology</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Time Factors</topic><topic>Tumors</topic><topic>Uterine Cervical Neoplasms - pathology</topic><topic>Vaginal Smears</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WRIGHT, Jason D</creatorcontrib><creatorcontrib>PINTO, Anil B</creatorcontrib><creatorcontrib>POWELL, Matthew A</creatorcontrib><creatorcontrib>LU, Danielle W</creatorcontrib><creatorcontrib>FENG GAO</creatorcontrib><creatorcontrib>PINTO, Karen R</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>WRIGHT, Jason D</au><au>PINTO, Anil B</au><au>POWELL, Matthew A</au><au>LU, Danielle W</au><au>FENG GAO</au><au>PINTO, Karen R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Atypical squamous cells of undetermined significance in girls and women</atitle><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle><addtitle>Obstet Gynecol</addtitle><date>2004-04-01</date><risdate>2004</risdate><volume>103</volume><issue>4</issue><spage>632</spage><epage>638</epage><pages>632-638</pages><issn>0029-7844</issn><eissn>1873-233X</eissn><coden>OBGNAS</coden><abstract>To estimate the outcome of adolescents with atypical squamous cells of undetermined significance (ASC-US) on cytology.
A review of ASC-US cytology in girls and women aged 10-19 years between 1995 and 1999 was performed. The cytologic and histologic follow-up of each patient was evaluated. The outcome was recorded as the most significant (highest grade) subsequent cervical smear or biopsy.
Overall, 535 of 7897 (6.8%) cervical cytologic specimens were reported as ASC-US. The study group consisted of 398 patients for whom pathologic follow-up was available. The mean duration of follow-up was 19 months. Follow-up consisted of repeat cytology in 251 (63%) patients and colposcopy with cervical biopsies and/or endocervical curettage in 147 (37%) of the adolescents. Two hundred fifty-three (64%) adolescents had no pathologic abnormalities on follow-up. Persistent ASC-US was identified in 65 (16%), low-grade squamous intraepithelial lesions/cervical intraepithelial neoplasia (CIN) 1 was found in 44 (11%) and high-grade squamous intraepithelial lesions/CIN 2 or 3 occurred in 36 (9%) of the adolescents. No cases of invasive carcinoma were found.
Among adolescents with ASC-US, the rate of squamous intraepithelial lesions/CIN is similar to that of adults. Although the optimal management of ASC-US in adolescents is unknown, these patients warrant close follow-up.
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adolescent Adult Age Factors Biological and medical sciences Cervical Intraepithelial Neoplasia - pathology Cervix Uteri - pathology Child Disease Progression Epithelial Cells - pathology Female Female genital diseases Follow-Up Studies Gynecology. Andrology. Obstetrics Humans Medical sciences Neoplasms, Squamous Cell - pathology Prognosis Retrospective Studies Time Factors Tumors Uterine Cervical Neoplasms - pathology Vaginal Smears |
| title | Atypical squamous cells of undetermined significance in girls and women |
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