Structure–activity relationships of untenone A and its derivatives for inhibition of DNA polymerases
We found that untenone A and mannzamenone A inhibit mammalian DNA polymerases α and β, and human terminal deoxynucleotidyl transferase (TdT). The syntheses of both compounds and the structure–activity relationships of untenone A derivatives are described. Graphic
Gespeichert in:
| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2004-04, Vol.14 (8), p.1975-1977 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1977 |
|---|---|
| container_issue | 8 |
| container_start_page | 1975 |
| container_title | Bioorganic & medicinal chemistry letters |
| container_volume | 14 |
| creator | Saito, Fumiyo Takeuchi, Ryo Kamino, Tomoyuki Kuramochi, Kouji Sugawara, Fumio Sakaguchi, Kengo Kobayashi, Susumu |
| description | We found that untenone A and mannzamenone A inhibit mammalian DNA polymerases α and β, and human terminal deoxynucleotidyl transferase (TdT). The syntheses of both compounds and the structure–activity relationships of untenone A derivatives are described.
Graphic |
| doi_str_mv | 10.1016/j.bmcl.2004.01.092 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71776937</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0960894X04001726</els_id><sourcerecordid>71776937</sourcerecordid><originalsourceid>FETCH-LOGICAL-c448t-b4a453685ec23441d421f36d2d3e2525a3fe136f0a65152cb6dbeac6ce09dc6c3</originalsourceid><addsrcrecordid>eNp9kMuKFDEUhoM4OO3oC7iQbHRX5cm1u8BNM-MNBmehgruQSk6YNHVpk1RD7-YdfMN5EqvoBl25Opvv-zl8hLxiUDNg-t2ubnvX1RxA1sBqaPgTsmJSy0pIUE_JChoN1aaRPy_J85x3AEyClM_IJVOgQEtYkfCtpMmVKeHjw2_rSjzEcqQJO1viOOT7uM90DHQaCg7jgHRL7eBpLJl6TPEwUwfMNIyJxuE-tnGxFuHm65bux-7YY7IZ8wtyEWyX8eX5XpEfHz98v_5c3d59-nK9va2clJtStdJKJfRGoeNCSuYlZ0Foz71ArriyIiATOoDViinuWu1btE47hMbPR1yRt6fdfRp_TZiL6WN22HV2wHHKZs3Wa92I9QzyE-jSmHPCYPYp9jYdDQOz1DU7s9Q1S10DzMx1Z-n1eX1qe_R_lXPOGXhzBmx2tgvJDi7mfzgtuNB65t6fOJxbHCImk13EwaGPCV0xfoz_--MPFUea_g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71776937</pqid></control><display><type>article</type><title>Structure–activity relationships of untenone A and its derivatives for inhibition of DNA polymerases</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Saito, Fumiyo ; Takeuchi, Ryo ; Kamino, Tomoyuki ; Kuramochi, Kouji ; Sugawara, Fumio ; Sakaguchi, Kengo ; Kobayashi, Susumu</creator><creatorcontrib>Saito, Fumiyo ; Takeuchi, Ryo ; Kamino, Tomoyuki ; Kuramochi, Kouji ; Sugawara, Fumio ; Sakaguchi, Kengo ; Kobayashi, Susumu</creatorcontrib><description>We found that untenone A and mannzamenone A inhibit mammalian DNA polymerases α and β, and human terminal deoxynucleotidyl transferase (TdT). The syntheses of both compounds and the structure–activity relationships of untenone A derivatives are described.
Graphic</description><identifier>ISSN: 0960-894X</identifier><identifier>EISSN: 1464-3405</identifier><identifier>DOI: 10.1016/j.bmcl.2004.01.092</identifier><identifier>PMID: 15050640</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Antineoplastic agents ; Biological and medical sciences ; Cyclopentanes - chemical synthesis ; Cyclopentanes - pharmacology ; DNA Nucleotidylexotransferase - antagonists & inhibitors ; Enzyme Inhibitors - chemical synthesis ; Enzyme Inhibitors - pharmacology ; Formates - chemical synthesis ; Formates - pharmacology ; General aspects ; Humans ; Indans - chemical synthesis ; Indans - pharmacology ; Levulinic Acids - chemical synthesis ; Levulinic Acids - pharmacology ; Medical sciences ; Molecular Structure ; Nucleic Acid Synthesis Inhibitors ; Pharmacology. Drug treatments ; Structure-Activity Relationship</subject><ispartof>Bioorganic & medicinal chemistry letters, 2004-04, Vol.14 (8), p.1975-1977</ispartof><rights>2004 Elsevier Ltd</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-b4a453685ec23441d421f36d2d3e2525a3fe136f0a65152cb6dbeac6ce09dc6c3</citedby><cites>FETCH-LOGICAL-c448t-b4a453685ec23441d421f36d2d3e2525a3fe136f0a65152cb6dbeac6ce09dc6c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0960894X04001726$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15632366$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15050640$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saito, Fumiyo</creatorcontrib><creatorcontrib>Takeuchi, Ryo</creatorcontrib><creatorcontrib>Kamino, Tomoyuki</creatorcontrib><creatorcontrib>Kuramochi, Kouji</creatorcontrib><creatorcontrib>Sugawara, Fumio</creatorcontrib><creatorcontrib>Sakaguchi, Kengo</creatorcontrib><creatorcontrib>Kobayashi, Susumu</creatorcontrib><title>Structure–activity relationships of untenone A and its derivatives for inhibition of DNA polymerases</title><title>Bioorganic & medicinal chemistry letters</title><addtitle>Bioorg Med Chem Lett</addtitle><description>We found that untenone A and mannzamenone A inhibit mammalian DNA polymerases α and β, and human terminal deoxynucleotidyl transferase (TdT). The syntheses of both compounds and the structure–activity relationships of untenone A derivatives are described.
Graphic</description><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>Cyclopentanes - chemical synthesis</subject><subject>Cyclopentanes - pharmacology</subject><subject>DNA Nucleotidylexotransferase - antagonists & inhibitors</subject><subject>Enzyme Inhibitors - chemical synthesis</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Formates - chemical synthesis</subject><subject>Formates - pharmacology</subject><subject>General aspects</subject><subject>Humans</subject><subject>Indans - chemical synthesis</subject><subject>Indans - pharmacology</subject><subject>Levulinic Acids - chemical synthesis</subject><subject>Levulinic Acids - pharmacology</subject><subject>Medical sciences</subject><subject>Molecular Structure</subject><subject>Nucleic Acid Synthesis Inhibitors</subject><subject>Pharmacology. Drug treatments</subject><subject>Structure-Activity Relationship</subject><issn>0960-894X</issn><issn>1464-3405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMuKFDEUhoM4OO3oC7iQbHRX5cm1u8BNM-MNBmehgruQSk6YNHVpk1RD7-YdfMN5EqvoBl25Opvv-zl8hLxiUDNg-t2ubnvX1RxA1sBqaPgTsmJSy0pIUE_JChoN1aaRPy_J85x3AEyClM_IJVOgQEtYkfCtpMmVKeHjw2_rSjzEcqQJO1viOOT7uM90DHQaCg7jgHRL7eBpLJl6TPEwUwfMNIyJxuE-tnGxFuHm65bux-7YY7IZ8wtyEWyX8eX5XpEfHz98v_5c3d59-nK9va2clJtStdJKJfRGoeNCSuYlZ0Foz71ArriyIiATOoDViinuWu1btE47hMbPR1yRt6fdfRp_TZiL6WN22HV2wHHKZs3Wa92I9QzyE-jSmHPCYPYp9jYdDQOz1DU7s9Q1S10DzMx1Z-n1eX1qe_R_lXPOGXhzBmx2tgvJDi7mfzgtuNB65t6fOJxbHCImk13EwaGPCV0xfoz_--MPFUea_g</recordid><startdate>20040419</startdate><enddate>20040419</enddate><creator>Saito, Fumiyo</creator><creator>Takeuchi, Ryo</creator><creator>Kamino, Tomoyuki</creator><creator>Kuramochi, Kouji</creator><creator>Sugawara, Fumio</creator><creator>Sakaguchi, Kengo</creator><creator>Kobayashi, Susumu</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040419</creationdate><title>Structure–activity relationships of untenone A and its derivatives for inhibition of DNA polymerases</title><author>Saito, Fumiyo ; Takeuchi, Ryo ; Kamino, Tomoyuki ; Kuramochi, Kouji ; Sugawara, Fumio ; Sakaguchi, Kengo ; Kobayashi, Susumu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-b4a453685ec23441d421f36d2d3e2525a3fe136f0a65152cb6dbeac6ce09dc6c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Antineoplastic agents</topic><topic>Biological and medical sciences</topic><topic>Cyclopentanes - chemical synthesis</topic><topic>Cyclopentanes - pharmacology</topic><topic>DNA Nucleotidylexotransferase - antagonists & inhibitors</topic><topic>Enzyme Inhibitors - chemical synthesis</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Formates - chemical synthesis</topic><topic>Formates - pharmacology</topic><topic>General aspects</topic><topic>Humans</topic><topic>Indans - chemical synthesis</topic><topic>Indans - pharmacology</topic><topic>Levulinic Acids - chemical synthesis</topic><topic>Levulinic Acids - pharmacology</topic><topic>Medical sciences</topic><topic>Molecular Structure</topic><topic>Nucleic Acid Synthesis Inhibitors</topic><topic>Pharmacology. Drug treatments</topic><topic>Structure-Activity Relationship</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saito, Fumiyo</creatorcontrib><creatorcontrib>Takeuchi, Ryo</creatorcontrib><creatorcontrib>Kamino, Tomoyuki</creatorcontrib><creatorcontrib>Kuramochi, Kouji</creatorcontrib><creatorcontrib>Sugawara, Fumio</creatorcontrib><creatorcontrib>Sakaguchi, Kengo</creatorcontrib><creatorcontrib>Kobayashi, Susumu</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bioorganic & medicinal chemistry letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saito, Fumiyo</au><au>Takeuchi, Ryo</au><au>Kamino, Tomoyuki</au><au>Kuramochi, Kouji</au><au>Sugawara, Fumio</au><au>Sakaguchi, Kengo</au><au>Kobayashi, Susumu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Structure–activity relationships of untenone A and its derivatives for inhibition of DNA polymerases</atitle><jtitle>Bioorganic & medicinal chemistry letters</jtitle><addtitle>Bioorg Med Chem Lett</addtitle><date>2004-04-19</date><risdate>2004</risdate><volume>14</volume><issue>8</issue><spage>1975</spage><epage>1977</epage><pages>1975-1977</pages><issn>0960-894X</issn><eissn>1464-3405</eissn><abstract>We found that untenone A and mannzamenone A inhibit mammalian DNA polymerases α and β, and human terminal deoxynucleotidyl transferase (TdT). The syntheses of both compounds and the structure–activity relationships of untenone A derivatives are described.
Graphic</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>15050640</pmid><doi>10.1016/j.bmcl.2004.01.092</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0960-894X |
| ispartof | Bioorganic & medicinal chemistry letters, 2004-04, Vol.14 (8), p.1975-1977 |
| issn | 0960-894X 1464-3405 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71776937 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Antineoplastic agents Biological and medical sciences Cyclopentanes - chemical synthesis Cyclopentanes - pharmacology DNA Nucleotidylexotransferase - antagonists & inhibitors Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - pharmacology Formates - chemical synthesis Formates - pharmacology General aspects Humans Indans - chemical synthesis Indans - pharmacology Levulinic Acids - chemical synthesis Levulinic Acids - pharmacology Medical sciences Molecular Structure Nucleic Acid Synthesis Inhibitors Pharmacology. Drug treatments Structure-Activity Relationship |
| title | Structure–activity relationships of untenone A and its derivatives for inhibition of DNA polymerases |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T16%3A03%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Structure%E2%80%93activity%20relationships%20of%20untenone%20A%20and%20its%20derivatives%20for%20inhibition%20of%20DNA%20polymerases&rft.jtitle=Bioorganic%20&%20medicinal%20chemistry%20letters&rft.au=Saito,%20Fumiyo&rft.date=2004-04-19&rft.volume=14&rft.issue=8&rft.spage=1975&rft.epage=1977&rft.pages=1975-1977&rft.issn=0960-894X&rft.eissn=1464-3405&rft_id=info:doi/10.1016/j.bmcl.2004.01.092&rft_dat=%3Cproquest_cross%3E71776937%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=71776937&rft_id=info:pmid/15050640&rft_els_id=S0960894X04001726&rfr_iscdi=true |