Morphological and biochemical integrity of human liver slices in long-term culture: Effects of oxygen tension

We tested the effects of low (20% O2) and high (70% O2) oxygen tension on the morphological and biochemical integrity of human liver slices incubated for up to 72 h in supplemented Williams' E medium in a dynamic rotating culture system. High oxygen tension was more effective than low oxygen te...

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Veröffentlicht in:	Cell biology and toxicology 2002-01, Vol.18 (2), p.73-85
Hauptverfasser:	MARTIN, H, SARSAT, J. P, LERCHE-LANGRAND, C, HOUSSET, C, BALLADUR, P, TOUTAIN, H, ALBALADEJO, V
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Biological material (laboratory animals, preparation of biological tracers, etc.) Cytochrome P-450 CYP2E1 - metabolism Cytochrome P-450 CYP3A Cytochrome P-450 Enzyme System - metabolism Female Fundamental and applied biological sciences. Psychology General aspects Glutathione - metabolism Humans Immunohistochemistry Liver - enzymology Liver - metabolism Liver - physiology Male Middle Aged Organ Culture Techniques Oxidative stress Oxygen Oxygen - metabolism Reactive Oxygen Species - metabolism
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