Preferential HER-2/neu overexpression and/or amplification in aggressive histological subtypes of invasive breast cancer
Aims: To investigate whether alterations of the HER2 gene occur more frequently in histologically unfavourable subtypes of invasive breast cancer. Methods: The study was composed of nine invasive apocrine, six lipid‐rich, 12 glycogen‐rich, 11 micropapillary and 33 pleomorphic lobular breast carcin...
Gespeichert in:
| Veröffentlicht in: | Histopathology 2004-04, Vol.44 (4), p.332-338 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 338 |
|---|---|
| container_issue | 4 |
| container_start_page | 332 |
| container_title | Histopathology |
| container_volume | 44 |
| creator | Varga, Z Zhao, J Öhlschlegel, C Odermatt, B Heitz, P U |
| description | Aims: To investigate whether alterations of the HER2 gene occur more frequently in histologically unfavourable subtypes of invasive breast cancer.
Methods: The study was composed of nine invasive apocrine, six lipid‐rich, 12 glycogen‐rich, 11 micropapillary and 33 pleomorphic lobular breast carcinomas. Lymph node involvement was represented in all subgroups. HER2 status was confirmed in all cases by using immunohistochemistry (CB11, Herceptest) and fluorescent in‐situ hybridization (FISH) analysis (Vysis).
Results: Micropapillary and apocrine carcinomas showed the highest rate of protein overexpression (72% and 66%) and gene amplification (45% and 44%). Protein overexpression was common in poorly differentiated pleomorphic lobular carcinomas (56%); however, this subgroup failed to show an increased number of gene copies by FISH (31%). The incidence of HER2 overexpression (33% and 50%, respectively) and gene amplification (25% and 33%, respectively) among glycogen‐rich and lipid‐rich carcinomas was not higher than that observed in breast cancer generally.
Conclusion: Our data suggest that preferential involvement of the HER2 gene in micropapillary and apocrine breast carcinomas may contribute to their aggressive behaviour. |
| doi_str_mv | 10.1111/j.1365-2559.2004.01843.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71776624</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>71776624</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5283-8fb0b6dea66109c4c96c29c72196d4397b94fb48cf097ca0cc0a9076f54ba27c3</originalsourceid><addsrcrecordid>eNqNkUuP0zAURi0EYsrAX0DewC6pX7HjBQs0M7QjlTdoZmc5rl1c0iTYSUn_PU5bDSzxxta957u2jgGAGOU4rfk2x5QXGSkKmROEWI5wyWg-PgKzh8ZjMEMUyQxhLi7Asxi3CGFBCXkKLnCBmCxlOQPjp2CdDbbpva7h8uZLRuaNHWC7T8WxCzZG3zZQN-t5G6DedbV33uh-KvpU32yOyN7CHz72bd1uUreGcaj6Q2cjbF3C9vpIVMHq2EOjG2PDc_DE6TraF-f9Enx_d_PtapmtPi5ur96uMlOQkmalq1DF11ZzjpE0zEhuiDSCYMnXjEpRSeYqVhqHpDAaGYO0RIK7glWaCEMvwevT3C60vwYbe7Xz0di61o1th6gEFoJzwhJYnkAT2hiTFdUFv9PhoDBSk3W1VZNcNclVk3V1tK7GFH15vmOodnb9N3jWnIBXZ0DHpMeFpMDHf7hCijQwcW9O3G9f28N_P0Atb79Op5TPTvn0F3Z8yOvwU3FBRaHuPizUnbhefb6_X6j39A874a8_</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71776624</pqid></control><display><type>article</type><title>Preferential HER-2/neu overexpression and/or amplification in aggressive histological subtypes of invasive breast cancer</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Varga, Z ; Zhao, J ; Öhlschlegel, C ; Odermatt, B ; Heitz, P U</creator><creatorcontrib>Varga, Z ; Zhao, J ; Öhlschlegel, C ; Odermatt, B ; Heitz, P U</creatorcontrib><description>Aims: To investigate whether alterations of the HER2 gene occur more frequently in histologically unfavourable subtypes of invasive breast cancer.
Methods: The study was composed of nine invasive apocrine, six lipid‐rich, 12 glycogen‐rich, 11 micropapillary and 33 pleomorphic lobular breast carcinomas. Lymph node involvement was represented in all subgroups. HER2 status was confirmed in all cases by using immunohistochemistry (CB11, Herceptest) and fluorescent in‐situ hybridization (FISH) analysis (Vysis).
Results: Micropapillary and apocrine carcinomas showed the highest rate of protein overexpression (72% and 66%) and gene amplification (45% and 44%). Protein overexpression was common in poorly differentiated pleomorphic lobular carcinomas (56%); however, this subgroup failed to show an increased number of gene copies by FISH (31%). The incidence of HER2 overexpression (33% and 50%, respectively) and gene amplification (25% and 33%, respectively) among glycogen‐rich and lipid‐rich carcinomas was not higher than that observed in breast cancer generally.
Conclusion: Our data suggest that preferential involvement of the HER2 gene in micropapillary and apocrine breast carcinomas may contribute to their aggressive behaviour.</description><identifier>ISSN: 0309-0167</identifier><identifier>EISSN: 1365-2559</identifier><identifier>DOI: 10.1111/j.1365-2559.2004.01843.x</identifier><identifier>PMID: 15049898</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Aged ; Biological and medical sciences ; breast cancer ; Breast Neoplasms - metabolism ; Breast Neoplasms - pathology ; Carcinoma - metabolism ; Carcinoma - pathology ; Female ; FISH ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Gene Amplification ; HER-2/neu ; Humans ; Immunohistochemistry ; Medical sciences ; Middle Aged ; Neoplasm Invasiveness ; Receptor, ErbB-2 - biosynthesis ; Receptor, ErbB-2 - genetics ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis ; special type ; Tumors ; unfavourable prognosis</subject><ispartof>Histopathology, 2004-04, Vol.44 (4), p.332-338</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5283-8fb0b6dea66109c4c96c29c72196d4397b94fb48cf097ca0cc0a9076f54ba27c3</citedby><cites>FETCH-LOGICAL-c5283-8fb0b6dea66109c4c96c29c72196d4397b94fb48cf097ca0cc0a9076f54ba27c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2559.2004.01843.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2559.2004.01843.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45552,45553</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15597004$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15049898$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Varga, Z</creatorcontrib><creatorcontrib>Zhao, J</creatorcontrib><creatorcontrib>Öhlschlegel, C</creatorcontrib><creatorcontrib>Odermatt, B</creatorcontrib><creatorcontrib>Heitz, P U</creatorcontrib><title>Preferential HER-2/neu overexpression and/or amplification in aggressive histological subtypes of invasive breast cancer</title><title>Histopathology</title><addtitle>Histopathology</addtitle><description>Aims: To investigate whether alterations of the HER2 gene occur more frequently in histologically unfavourable subtypes of invasive breast cancer.
Methods: The study was composed of nine invasive apocrine, six lipid‐rich, 12 glycogen‐rich, 11 micropapillary and 33 pleomorphic lobular breast carcinomas. Lymph node involvement was represented in all subgroups. HER2 status was confirmed in all cases by using immunohistochemistry (CB11, Herceptest) and fluorescent in‐situ hybridization (FISH) analysis (Vysis).
Results: Micropapillary and apocrine carcinomas showed the highest rate of protein overexpression (72% and 66%) and gene amplification (45% and 44%). Protein overexpression was common in poorly differentiated pleomorphic lobular carcinomas (56%); however, this subgroup failed to show an increased number of gene copies by FISH (31%). The incidence of HER2 overexpression (33% and 50%, respectively) and gene amplification (25% and 33%, respectively) among glycogen‐rich and lipid‐rich carcinomas was not higher than that observed in breast cancer generally.
Conclusion: Our data suggest that preferential involvement of the HER2 gene in micropapillary and apocrine breast carcinomas may contribute to their aggressive behaviour.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>breast cancer</subject><subject>Breast Neoplasms - metabolism</subject><subject>Breast Neoplasms - pathology</subject><subject>Carcinoma - metabolism</subject><subject>Carcinoma - pathology</subject><subject>Female</subject><subject>FISH</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Gene Amplification</subject><subject>HER-2/neu</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness</subject><subject>Receptor, ErbB-2 - biosynthesis</subject><subject>Receptor, ErbB-2 - genetics</subject><subject>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</subject><subject>special type</subject><subject>Tumors</subject><subject>unfavourable prognosis</subject><issn>0309-0167</issn><issn>1365-2559</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUuP0zAURi0EYsrAX0DewC6pX7HjBQs0M7QjlTdoZmc5rl1c0iTYSUn_PU5bDSzxxta957u2jgGAGOU4rfk2x5QXGSkKmROEWI5wyWg-PgKzh8ZjMEMUyQxhLi7Asxi3CGFBCXkKLnCBmCxlOQPjp2CdDbbpva7h8uZLRuaNHWC7T8WxCzZG3zZQN-t5G6DedbV33uh-KvpU32yOyN7CHz72bd1uUreGcaj6Q2cjbF3C9vpIVMHq2EOjG2PDc_DE6TraF-f9Enx_d_PtapmtPi5ur96uMlOQkmalq1DF11ZzjpE0zEhuiDSCYMnXjEpRSeYqVhqHpDAaGYO0RIK7glWaCEMvwevT3C60vwYbe7Xz0di61o1th6gEFoJzwhJYnkAT2hiTFdUFv9PhoDBSk3W1VZNcNclVk3V1tK7GFH15vmOodnb9N3jWnIBXZ0DHpMeFpMDHf7hCijQwcW9O3G9f28N_P0Atb79Op5TPTvn0F3Z8yOvwU3FBRaHuPizUnbhefb6_X6j39A874a8_</recordid><startdate>200404</startdate><enddate>200404</enddate><creator>Varga, Z</creator><creator>Zhao, J</creator><creator>Öhlschlegel, C</creator><creator>Odermatt, B</creator><creator>Heitz, P U</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200404</creationdate><title>Preferential HER-2/neu overexpression and/or amplification in aggressive histological subtypes of invasive breast cancer</title><author>Varga, Z ; Zhao, J ; Öhlschlegel, C ; Odermatt, B ; Heitz, P U</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5283-8fb0b6dea66109c4c96c29c72196d4397b94fb48cf097ca0cc0a9076f54ba27c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>breast cancer</topic><topic>Breast Neoplasms - metabolism</topic><topic>Breast Neoplasms - pathology</topic><topic>Carcinoma - metabolism</topic><topic>Carcinoma - pathology</topic><topic>Female</topic><topic>FISH</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Gene Amplification</topic><topic>HER-2/neu</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness</topic><topic>Receptor, ErbB-2 - biosynthesis</topic><topic>Receptor, ErbB-2 - genetics</topic><topic>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</topic><topic>special type</topic><topic>Tumors</topic><topic>unfavourable prognosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Varga, Z</creatorcontrib><creatorcontrib>Zhao, J</creatorcontrib><creatorcontrib>Öhlschlegel, C</creatorcontrib><creatorcontrib>Odermatt, B</creatorcontrib><creatorcontrib>Heitz, P U</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Histopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Varga, Z</au><au>Zhao, J</au><au>Öhlschlegel, C</au><au>Odermatt, B</au><au>Heitz, P U</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preferential HER-2/neu overexpression and/or amplification in aggressive histological subtypes of invasive breast cancer</atitle><jtitle>Histopathology</jtitle><addtitle>Histopathology</addtitle><date>2004-04</date><risdate>2004</risdate><volume>44</volume><issue>4</issue><spage>332</spage><epage>338</epage><pages>332-338</pages><issn>0309-0167</issn><eissn>1365-2559</eissn><abstract>Aims: To investigate whether alterations of the HER2 gene occur more frequently in histologically unfavourable subtypes of invasive breast cancer.
Methods: The study was composed of nine invasive apocrine, six lipid‐rich, 12 glycogen‐rich, 11 micropapillary and 33 pleomorphic lobular breast carcinomas. Lymph node involvement was represented in all subgroups. HER2 status was confirmed in all cases by using immunohistochemistry (CB11, Herceptest) and fluorescent in‐situ hybridization (FISH) analysis (Vysis).
Results: Micropapillary and apocrine carcinomas showed the highest rate of protein overexpression (72% and 66%) and gene amplification (45% and 44%). Protein overexpression was common in poorly differentiated pleomorphic lobular carcinomas (56%); however, this subgroup failed to show an increased number of gene copies by FISH (31%). The incidence of HER2 overexpression (33% and 50%, respectively) and gene amplification (25% and 33%, respectively) among glycogen‐rich and lipid‐rich carcinomas was not higher than that observed in breast cancer generally.
Conclusion: Our data suggest that preferential involvement of the HER2 gene in micropapillary and apocrine breast carcinomas may contribute to their aggressive behaviour.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>15049898</pmid><doi>10.1111/j.1365-2559.2004.01843.x</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0309-0167 |
| ispartof | Histopathology, 2004-04, Vol.44 (4), p.332-338 |
| issn | 0309-0167 1365-2559 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71776624 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Aged Biological and medical sciences breast cancer Breast Neoplasms - metabolism Breast Neoplasms - pathology Carcinoma - metabolism Carcinoma - pathology Female FISH Fundamental and applied biological sciences. Psychology Fundamental immunology Gene Amplification HER-2/neu Humans Immunohistochemistry Medical sciences Middle Aged Neoplasm Invasiveness Receptor, ErbB-2 - biosynthesis Receptor, ErbB-2 - genetics Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis special type Tumors unfavourable prognosis |
| title | Preferential HER-2/neu overexpression and/or amplification in aggressive histological subtypes of invasive breast cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T08%3A04%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Preferential%20HER-2/neu%20overexpression%20and/or%20amplification%20in%20aggressive%20histological%20subtypes%20of%20invasive%20breast%20cancer&rft.jtitle=Histopathology&rft.au=Varga,%20Z&rft.date=2004-04&rft.volume=44&rft.issue=4&rft.spage=332&rft.epage=338&rft.pages=332-338&rft.issn=0309-0167&rft.eissn=1365-2559&rft_id=info:doi/10.1111/j.1365-2559.2004.01843.x&rft_dat=%3Cproquest_cross%3E71776624%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=71776624&rft_id=info:pmid/15049898&rfr_iscdi=true |