CD6: expression during development, apoptosis and selection of human and mouse thymocytes

CD6, a 130-kDa surface glycoprotein, is expressed primarily on cells of T lineage. A co-stimulatory role for CD6 in mature T cells has been shown, but the function of CD6 during thymocyte development is unknown. Since CD6 ligands are expressed on thymic epithelium, their interactions with CD6 could...

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Veröffentlicht in:	International immunology 2002-06, Vol.14 (6), p.585-597
Hauptverfasser:	Singer, Nora G, Fox, David A, Haqqi, Tariq M, Beretta, Laura, Endres, Judith S, Prohaska, Susan, Parnes, Jane R, Bromberg, Jonathan, Sramkoski, R Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD - metabolism Antigens, Differentiation, T-Lymphocyte - metabolism Apoptosis - immunology CD2 Antigens - metabolism Cell Differentiation Cell Survival Humans In Vitro Techniques Infant Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Receptors, Antigen, T-Cell - genetics Receptors, Antigen, T-Cell - metabolism Signal Transduction T-Lymphocyte Subsets - cytology T-Lymphocyte Subsets - immunology T-Lymphocytes - cytology T-Lymphocytes - immunology
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