Mediator–Nucleosome Interaction

Mediator, a multiprotein complex involved in the regulation of RNA polymerase II transcription, binds to nucleosomes and acetylates histones. Three lines of evidence identify the Nut1 subunit of Mediator as responsible for the histone acetyltransferase (HAT) activity. An “in-gel” HAT assay reveals a...

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Veröffentlicht in:	Molecular cell 2000-07, Vol.6 (1), p.197-201
Hauptverfasser:	Lorch, Yahli, Beve, Jenny, Gustafsson, Claes M., Myers, Lawrence C., Kornberg, Roger D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetyltransferases - chemistry Acetyltransferases - genetics Acetyltransferases - metabolism Amino Acid Sequence Base Sequence DNA Primers - genetics Fungal Proteins - chemistry Fungal Proteins - genetics Fungal Proteins - metabolism histone acetyltransferase Histone Acetyltransferases Macromolecular Substances Mediator Complex Molecular Sequence Data Multiprotein Complexes Nuclear Proteins - chemistry Nuclear Proteins - genetics Nuclear Proteins - metabolism Nucleosomes - metabolism Nut1 protein RNA Polymerase II - metabolism Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins Sequence Homology, Amino Acid
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