Relaxation effects of adrenomedullin in isolated rabbit corpus cavernosum smooth muscle
OBJECTIVES To clarify the pharmacological effects of adrenomedullin, a potent vasodilator and hypotensive peptide isolated from human phaeochromocytoma cells, on corpus cavernosal smooth muscle in vitro, as the intracavernosal injection of adrenomedullin induces penile erection in the anaesthetized...
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| Veröffentlicht in: | BJU international 2004-04, Vol.93 (6), p.859-862 |
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| creator | Gokce, G. Bagcivan, I. Kilicarslan, H. Yildirim, S. Gultekin, Y.E. Sarioglu, Y. |
| description | OBJECTIVES
To clarify the pharmacological effects of adrenomedullin, a potent vasodilator and hypotensive peptide isolated from human phaeochromocytoma cells, on corpus cavernosal smooth muscle in vitro, as the intracavernosal injection of adrenomedullin induces penile erection in the anaesthetized cat.
MATERIALS AND METHODS
The effects of adrenomedullin were investigated in isolated muscle strips from New Zealand rabbit corpus cavernosum smooth muscle pre‐contracted with phenylephrine alone, in the presence of indomethacin (cyclooxygenase inhibitor), Nω‐nitro l‐arginine methyl ester (L‐NAME, a nitric oxide synthase inhibitor), and K+‐channel blockers.
RESULTS
Adrenomedullin caused relaxation of isolated pre‐contracted rabbit corpus cavernosum strips in a concentration‐dependent manner. The response of corpus cavernosum was unaffected L‐NAME, indomethacin and K+‐channel blockers
CONCLUSION
The relaxation exerted by adrenomedullin in rabbit corporal tissue may arise from the effect of the drug on its specific receptors and/or calcitonin gene‐related peptide‐1 receptors. The relaxant effect of adrenomedullin might lead to novel clinical applications for erectile dysfunction. |
| doi_str_mv | 10.1111/j.1464-410X.2003.04728.x |
| format | Article |
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To clarify the pharmacological effects of adrenomedullin, a potent vasodilator and hypotensive peptide isolated from human phaeochromocytoma cells, on corpus cavernosal smooth muscle in vitro, as the intracavernosal injection of adrenomedullin induces penile erection in the anaesthetized cat.
MATERIALS AND METHODS
The effects of adrenomedullin were investigated in isolated muscle strips from New Zealand rabbit corpus cavernosum smooth muscle pre‐contracted with phenylephrine alone, in the presence of indomethacin (cyclooxygenase inhibitor), Nω‐nitro l‐arginine methyl ester (L‐NAME, a nitric oxide synthase inhibitor), and K+‐channel blockers.
RESULTS
Adrenomedullin caused relaxation of isolated pre‐contracted rabbit corpus cavernosum strips in a concentration‐dependent manner. The response of corpus cavernosum was unaffected L‐NAME, indomethacin and K+‐channel blockers
CONCLUSION
The relaxation exerted by adrenomedullin in rabbit corporal tissue may arise from the effect of the drug on its specific receptors and/or calcitonin gene‐related peptide‐1 receptors. The relaxant effect of adrenomedullin might lead to novel clinical applications for erectile dysfunction.</description><identifier>ISSN: 1464-4096</identifier><identifier>EISSN: 1464-410X</identifier><identifier>DOI: 10.1111/j.1464-410X.2003.04728.x</identifier><identifier>PMID: 15050005</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Adrenomedullin ; Animals ; Biological and medical sciences ; corpus cavernosum ; erectile dysfunction ; Genital system. Reproduction ; In Vitro Techniques ; Male ; Medical sciences ; Muscle Relaxation - drug effects ; Muscle, Smooth - drug effects ; NG-Nitroarginine Methyl Ester - pharmacology ; Penile Erection - drug effects ; Penis - drug effects ; Peptides - pharmacology ; Pharmacology. Drug treatments ; Rabbits ; Vasodilator Agents - pharmacology</subject><ispartof>BJU international, 2004-04, Vol.93 (6), p.859-862</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3958-4bb261b30bf9c9931b02d2954afb804bb7f386c259f2b1d0fa016c6171e3f0b43</citedby><cites>FETCH-LOGICAL-c3958-4bb261b30bf9c9931b02d2954afb804bb7f386c259f2b1d0fa016c6171e3f0b43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1464-410X.2003.04728.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1464-410X.2003.04728.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15653956$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15050005$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gokce, G.</creatorcontrib><creatorcontrib>Bagcivan, I.</creatorcontrib><creatorcontrib>Kilicarslan, H.</creatorcontrib><creatorcontrib>Yildirim, S.</creatorcontrib><creatorcontrib>Gultekin, Y.E.</creatorcontrib><creatorcontrib>Sarioglu, Y.</creatorcontrib><title>Relaxation effects of adrenomedullin in isolated rabbit corpus cavernosum smooth muscle</title><title>BJU international</title><addtitle>BJU Int</addtitle><description>OBJECTIVES
To clarify the pharmacological effects of adrenomedullin, a potent vasodilator and hypotensive peptide isolated from human phaeochromocytoma cells, on corpus cavernosal smooth muscle in vitro, as the intracavernosal injection of adrenomedullin induces penile erection in the anaesthetized cat.
MATERIALS AND METHODS
The effects of adrenomedullin were investigated in isolated muscle strips from New Zealand rabbit corpus cavernosum smooth muscle pre‐contracted with phenylephrine alone, in the presence of indomethacin (cyclooxygenase inhibitor), Nω‐nitro l‐arginine methyl ester (L‐NAME, a nitric oxide synthase inhibitor), and K+‐channel blockers.
RESULTS
Adrenomedullin caused relaxation of isolated pre‐contracted rabbit corpus cavernosum strips in a concentration‐dependent manner. The response of corpus cavernosum was unaffected L‐NAME, indomethacin and K+‐channel blockers
CONCLUSION
The relaxation exerted by adrenomedullin in rabbit corporal tissue may arise from the effect of the drug on its specific receptors and/or calcitonin gene‐related peptide‐1 receptors. The relaxant effect of adrenomedullin might lead to novel clinical applications for erectile dysfunction.</description><subject>Adrenomedullin</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>corpus cavernosum</subject><subject>erectile dysfunction</subject><subject>Genital system. Reproduction</subject><subject>In Vitro Techniques</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Muscle Relaxation - drug effects</subject><subject>Muscle, Smooth - drug effects</subject><subject>NG-Nitroarginine Methyl Ester - pharmacology</subject><subject>Penile Erection - drug effects</subject><subject>Penis - drug effects</subject><subject>Peptides - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Rabbits</subject><subject>Vasodilator Agents - pharmacology</subject><issn>1464-4096</issn><issn>1464-410X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEtPxCAQgInR-P4Lhovetg4tpe3Bg258xsTEaPRGgELshpYVWl3_vdRdH0cJCZOZb2D4EMIEEhLX8SwhlNEJJfCcpABZArRIy2SxhrZ_CuvfMVRsC-2EMAOICZZvoi2SQw4A-TZ6utdWLETfuA5rY7TqA3YGi9rrzrW6HqxtOjzu4KzodY29kLLpsXJ-PgSsxJv2nQtDi0PrXP-C2yEoq_fQhhE26P3VuYseL84fpleT27vL6-np7URlVV5OqJQpIzIDaSpVVRmRkNZplVNhZAmxWpisZCrNK5NKUoMRQJhipCA6MyBptouOlvfOvXsddOh52wSlrRWddkPgBSkKWtIiguUSVN6F4LXhc9-0wn9wAnyUymd89MVHd3yUyr-k8kVsPVi9Mcio5LdxZTEChytABCWs8aJTTfjDsTz-lkXuZMm9N1Z__HsAfnbzOEbZJ8Rjk9c</recordid><startdate>200404</startdate><enddate>200404</enddate><creator>Gokce, G.</creator><creator>Bagcivan, I.</creator><creator>Kilicarslan, H.</creator><creator>Yildirim, S.</creator><creator>Gultekin, Y.E.</creator><creator>Sarioglu, Y.</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200404</creationdate><title>Relaxation effects of adrenomedullin in isolated rabbit corpus cavernosum smooth muscle</title><author>Gokce, G. ; Bagcivan, I. ; Kilicarslan, H. ; Yildirim, S. ; Gultekin, Y.E. ; Sarioglu, Y.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3958-4bb261b30bf9c9931b02d2954afb804bb7f386c259f2b1d0fa016c6171e3f0b43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adrenomedullin</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>corpus cavernosum</topic><topic>erectile dysfunction</topic><topic>Genital system. Reproduction</topic><topic>In Vitro Techniques</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Muscle Relaxation - drug effects</topic><topic>Muscle, Smooth - drug effects</topic><topic>NG-Nitroarginine Methyl Ester - pharmacology</topic><topic>Penile Erection - drug effects</topic><topic>Penis - drug effects</topic><topic>Peptides - pharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Rabbits</topic><topic>Vasodilator Agents - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gokce, G.</creatorcontrib><creatorcontrib>Bagcivan, I.</creatorcontrib><creatorcontrib>Kilicarslan, H.</creatorcontrib><creatorcontrib>Yildirim, S.</creatorcontrib><creatorcontrib>Gultekin, Y.E.</creatorcontrib><creatorcontrib>Sarioglu, Y.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>BJU international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gokce, G.</au><au>Bagcivan, I.</au><au>Kilicarslan, H.</au><au>Yildirim, S.</au><au>Gultekin, Y.E.</au><au>Sarioglu, Y.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relaxation effects of adrenomedullin in isolated rabbit corpus cavernosum smooth muscle</atitle><jtitle>BJU international</jtitle><addtitle>BJU Int</addtitle><date>2004-04</date><risdate>2004</risdate><volume>93</volume><issue>6</issue><spage>859</spage><epage>862</epage><pages>859-862</pages><issn>1464-4096</issn><eissn>1464-410X</eissn><abstract>OBJECTIVES
To clarify the pharmacological effects of adrenomedullin, a potent vasodilator and hypotensive peptide isolated from human phaeochromocytoma cells, on corpus cavernosal smooth muscle in vitro, as the intracavernosal injection of adrenomedullin induces penile erection in the anaesthetized cat.
MATERIALS AND METHODS
The effects of adrenomedullin were investigated in isolated muscle strips from New Zealand rabbit corpus cavernosum smooth muscle pre‐contracted with phenylephrine alone, in the presence of indomethacin (cyclooxygenase inhibitor), Nω‐nitro l‐arginine methyl ester (L‐NAME, a nitric oxide synthase inhibitor), and K+‐channel blockers.
RESULTS
Adrenomedullin caused relaxation of isolated pre‐contracted rabbit corpus cavernosum strips in a concentration‐dependent manner. The response of corpus cavernosum was unaffected L‐NAME, indomethacin and K+‐channel blockers
CONCLUSION
The relaxation exerted by adrenomedullin in rabbit corporal tissue may arise from the effect of the drug on its specific receptors and/or calcitonin gene‐related peptide‐1 receptors. The relaxant effect of adrenomedullin might lead to novel clinical applications for erectile dysfunction.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>15050005</pmid><doi>10.1111/j.1464-410X.2003.04728.x</doi><tpages>4</tpages></addata></record> |
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| subjects | Adrenomedullin Animals Biological and medical sciences corpus cavernosum erectile dysfunction Genital system. Reproduction In Vitro Techniques Male Medical sciences Muscle Relaxation - drug effects Muscle, Smooth - drug effects NG-Nitroarginine Methyl Ester - pharmacology Penile Erection - drug effects Penis - drug effects Peptides - pharmacology Pharmacology. Drug treatments Rabbits Vasodilator Agents - pharmacology |
| title | Relaxation effects of adrenomedullin in isolated rabbit corpus cavernosum smooth muscle |
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