Activation of RhoA by Thrombin in Endothelial Hyperpermeability: Role of Rho Kinase and Protein Tyrosine Kinases

Endothelial cells (ECs) actively regulate the extravasation of blood constituents. On stimulation by vasoactive agents and thrombin, ECs change their cytoskeletal architecture and small gaps are formed between neighboring cells. These changes partly depend on a rise in [Ca]i and activation of the Ca...

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Veröffentlicht in:	Circulation research 2000-08, Vol.87 (4), p.335-340
Hauptverfasser:	Amerongen, Geerten P. van Nieuw, Delft, Sanne van, Vermeer, Mario A, Collard, John G, van Hinsbergh, Victor W. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - pharmacology Biological and medical sciences Blood vessels and receptors Calcium - metabolism Cell Membrane Permeability - drug effects Cell Membrane Permeability - physiology Cells, Cultured Cytoskeleton - metabolism Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Endothelium, Vascular - enzymology Enzyme Activation - drug effects Enzyme Activation - physiology Enzyme Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology Hemostatics - pharmacology Humans Intracellular Signaling Peptides and Proteins Myosin Light Chains - metabolism Phosphorylation Protein Binding - drug effects Protein Binding - physiology Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - metabolism Protein-Tyrosine Kinases - metabolism Proto-Oncogene Proteins c-akt Pyridines - pharmacology rho-Associated Kinases rhoA GTP-Binding Protein - metabolism Thrombin - pharmacology Umbilical Veins - cytology Vertebrates: cardiovascular system
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