Age-Related Dysregulation in CD8 T Cell Homeostasis: Kinetics of a Diversity Loss

Relative diversity and representation of peripheral T cells bearing different TCR Vbeta families are remarkably tightly regulated between birth and advanced adulthood. By contrast, individual elderly humans and C3H.SW and B10.BR aged mice display drastic disruption in such regulation. It was suggest...

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Veröffentlicht in:	The Journal of immunology (1950) 2000-09, Vol.165 (5), p.2367-2373
Hauptverfasser:	LeMaoult, Joel, Messaoudi, Ilhem, Manavalan, John S, Potvin, Heather, Dyall, Ruben, Szabo, Paul, Weksler, Marc E
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - immunology AIDS/HIV Animals CD8 antigen CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cell Division - immunology Clone Cells Female Gene Rearrangement, beta-Chain T-Cell Antigen Receptor Homeostasis - immunology Kinetics Longitudinal Studies Lymphocyte Activation Lymphocyte Count Mice Mice, Inbred C3H Mice, Inbred C57BL Mice, Knockout Receptors, Antigen, T-Cell, alpha-beta - analysis Receptors, Antigen, T-Cell, alpha-beta - biosynthesis T-Lymphocyte Subsets - cytology T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism
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