Polymorphic distribution of the ovine prion protein ( PrP) gene in scrapie-infected sheep flocks in which embryo transfer was used to circumvent the transmissions of scrapie
The genetic sequence of the ovine prion protein ( PrP) gene between codons 102 and 175 with emphasis on ovine PrP gene codons 136 and 171 was determined, and the polymorphic distribution of the ovine PrP gene in the scrapie-exposed Suffolk embryo donors and offspring from these donors that were tran...
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| Veröffentlicht in: | Theriogenology 2002-04, Vol.57 (7), p.1865-1875 |
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| container_title | Theriogenology |
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| creator | Wang, Shiquan Cockett, Noelle E. Miller, Janice M. Shay, Tracy L. Maciulis, Alma Sutton, Diane L. Foote, Warren C. Holyoak, Gilbert R. Evans, Ronald C. Bunch, Thomas D. Beever, Jonathan E. Call, Jay W. Taylor, William D. Marshall, Michael R. |
| description | The genetic sequence of the ovine prion protein (
PrP) gene between codons 102 and 175 with emphasis on ovine
PrP gene codons 136 and 171 was determined, and the polymorphic distribution of the ovine
PrP gene in the scrapie-exposed Suffolk embryo donors and offspring from these donors that were transferred to scrapie-free recipient ewes was investigated in this study. The most common genotype was
AA
136
QQ
171 (70% and 63% in the donor and offspring flocks, respectively), which is considered a high risk genotype in US Suffolk sheep. Although embryos were collected from scrapie-positive donors and many embryos had the high risk genotype, no scrapie occurred in the resulting offspring. Based upon the results of this study, we conclude that vertical transmission of scrapie can be circumvented using embryo transfer procedures even when the offspring have the high risk genotype. |
| doi_str_mv | 10.1016/S0093-691X(02)00673-8 |
| format | Article |
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PrP) gene between codons 102 and 175 with emphasis on ovine
PrP gene codons 136 and 171 was determined, and the polymorphic distribution of the ovine
PrP gene in the scrapie-exposed Suffolk embryo donors and offspring from these donors that were transferred to scrapie-free recipient ewes was investigated in this study. The most common genotype was
AA
136
QQ
171 (70% and 63% in the donor and offspring flocks, respectively), which is considered a high risk genotype in US Suffolk sheep. Although embryos were collected from scrapie-positive donors and many embryos had the high risk genotype, no scrapie occurred in the resulting offspring. Based upon the results of this study, we conclude that vertical transmission of scrapie can be circumvented using embryo transfer procedures even when the offspring have the high risk genotype.</description><identifier>ISSN: 0093-691X</identifier><identifier>EISSN: 1879-3231</identifier><identifier>DOI: 10.1016/S0093-691X(02)00673-8</identifier><identifier>PMID: 12041690</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Alleles ; Animals ; DNA sequence ; Embryo transfer ; Embryo Transfer - veterinary ; Female ; Gene Frequency ; Genotype ; Infectious Disease Transmission, Vertical ; Ovine prion protein gene (ovine PrP gene) ; Polymorphism, Genetic ; Prions - genetics ; Scrapie ; Scrapie - genetics ; Scrapie - prevention & control ; Scrapie - transmission ; Sheep ; Suffolk ; Tissue and Organ Harvesting - methods ; Tissue and Organ Harvesting - veterinary</subject><ispartof>Theriogenology, 2002-04, Vol.57 (7), p.1865-1875</ispartof><rights>2002 Elsevier Science Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c361t-adde8452766e24faddef7a91dd74f10ef28aca1f4540fad37b12572c1d74d9a23</citedby><cites>FETCH-LOGICAL-c361t-adde8452766e24faddef7a91dd74f10ef28aca1f4540fad37b12572c1d74d9a23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0093691X02006738$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12041690$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Shiquan</creatorcontrib><creatorcontrib>Cockett, Noelle E.</creatorcontrib><creatorcontrib>Miller, Janice M.</creatorcontrib><creatorcontrib>Shay, Tracy L.</creatorcontrib><creatorcontrib>Maciulis, Alma</creatorcontrib><creatorcontrib>Sutton, Diane L.</creatorcontrib><creatorcontrib>Foote, Warren C.</creatorcontrib><creatorcontrib>Holyoak, Gilbert R.</creatorcontrib><creatorcontrib>Evans, Ronald C.</creatorcontrib><creatorcontrib>Bunch, Thomas D.</creatorcontrib><creatorcontrib>Beever, Jonathan E.</creatorcontrib><creatorcontrib>Call, Jay W.</creatorcontrib><creatorcontrib>Taylor, William D.</creatorcontrib><creatorcontrib>Marshall, Michael R.</creatorcontrib><title>Polymorphic distribution of the ovine prion protein ( PrP) gene in scrapie-infected sheep flocks in which embryo transfer was used to circumvent the transmissions of scrapie</title><title>Theriogenology</title><addtitle>Theriogenology</addtitle><description>The genetic sequence of the ovine prion protein (
PrP) gene between codons 102 and 175 with emphasis on ovine
PrP gene codons 136 and 171 was determined, and the polymorphic distribution of the ovine
PrP gene in the scrapie-exposed Suffolk embryo donors and offspring from these donors that were transferred to scrapie-free recipient ewes was investigated in this study. The most common genotype was
AA
136
QQ
171 (70% and 63% in the donor and offspring flocks, respectively), which is considered a high risk genotype in US Suffolk sheep. Although embryos were collected from scrapie-positive donors and many embryos had the high risk genotype, no scrapie occurred in the resulting offspring. Based upon the results of this study, we conclude that vertical transmission of scrapie can be circumvented using embryo transfer procedures even when the offspring have the high risk genotype.</description><subject>Alleles</subject><subject>Animals</subject><subject>DNA sequence</subject><subject>Embryo transfer</subject><subject>Embryo Transfer - veterinary</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genotype</subject><subject>Infectious Disease Transmission, Vertical</subject><subject>Ovine prion protein gene (ovine PrP gene)</subject><subject>Polymorphism, Genetic</subject><subject>Prions - genetics</subject><subject>Scrapie</subject><subject>Scrapie - genetics</subject><subject>Scrapie - prevention & control</subject><subject>Scrapie - transmission</subject><subject>Sheep</subject><subject>Suffolk</subject><subject>Tissue and Organ Harvesting - methods</subject><subject>Tissue and Organ Harvesting - veterinary</subject><issn>0093-691X</issn><issn>1879-3231</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9uEzEQxi1ERdOURwD5hNrDgv9s7N0TqioKSJUaCSpxsxx7TAy768X2pspD8Y54kwiOnKzx_Ga-mfkQekXJW0qoePeFkJZXoqXfrgi7JkRIXjXP0II2sq044_Q5WvxFztFFSj8IIVwI-gKdU0ZqKlqyQL_Xodv3IY5bb7D1KUe_mbIPAw4O5y3gsPMD4DHOX2MMGfyAr_A6rq_xdyiZEiYT9eih8oMDk8HitAUYseuC-Zlm4Kk032LoN3EfcI56SA4iftIJT6ngOWDjo5n6HQz5IHpgep9SUU3zJCeJS3TmdJfg5eldose7D19vP1X3Dx8_397cV4YLmittLTT1ikkhgNVuDp3ULbVW1o4ScKzRRlNXr2pSslxuKFtJZmjJ21YzvkRvjn3Lxr8mSFmVYQx0nR4gTElJKiWn5ZxLtDqCJoaUIjhVLtXruFeUqNkndfBJzSYowtTBJ9WUutcngWnTg_1XdTKmAO-PAJQ1dx6iSsbDYMD6WI6sbPD_kfgDgvSnrg</recordid><startdate>20020415</startdate><enddate>20020415</enddate><creator>Wang, Shiquan</creator><creator>Cockett, Noelle E.</creator><creator>Miller, Janice M.</creator><creator>Shay, Tracy L.</creator><creator>Maciulis, Alma</creator><creator>Sutton, Diane L.</creator><creator>Foote, Warren C.</creator><creator>Holyoak, Gilbert R.</creator><creator>Evans, Ronald C.</creator><creator>Bunch, Thomas D.</creator><creator>Beever, Jonathan E.</creator><creator>Call, Jay W.</creator><creator>Taylor, William D.</creator><creator>Marshall, Michael R.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020415</creationdate><title>Polymorphic distribution of the ovine prion protein ( PrP) gene in scrapie-infected sheep flocks in which embryo transfer was used to circumvent the transmissions of scrapie</title><author>Wang, Shiquan ; Cockett, Noelle E. ; Miller, Janice M. ; Shay, Tracy L. ; Maciulis, Alma ; Sutton, Diane L. ; Foote, Warren C. ; Holyoak, Gilbert R. ; Evans, Ronald C. ; Bunch, Thomas D. ; Beever, Jonathan E. ; Call, Jay W. ; Taylor, William D. ; Marshall, Michael R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c361t-adde8452766e24faddef7a91dd74f10ef28aca1f4540fad37b12572c1d74d9a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Alleles</topic><topic>Animals</topic><topic>DNA sequence</topic><topic>Embryo transfer</topic><topic>Embryo Transfer - veterinary</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genotype</topic><topic>Infectious Disease Transmission, Vertical</topic><topic>Ovine prion protein gene (ovine PrP gene)</topic><topic>Polymorphism, Genetic</topic><topic>Prions - genetics</topic><topic>Scrapie</topic><topic>Scrapie - genetics</topic><topic>Scrapie - prevention & control</topic><topic>Scrapie - transmission</topic><topic>Sheep</topic><topic>Suffolk</topic><topic>Tissue and Organ Harvesting - methods</topic><topic>Tissue and Organ Harvesting - veterinary</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Shiquan</creatorcontrib><creatorcontrib>Cockett, Noelle E.</creatorcontrib><creatorcontrib>Miller, Janice M.</creatorcontrib><creatorcontrib>Shay, Tracy L.</creatorcontrib><creatorcontrib>Maciulis, Alma</creatorcontrib><creatorcontrib>Sutton, Diane L.</creatorcontrib><creatorcontrib>Foote, Warren C.</creatorcontrib><creatorcontrib>Holyoak, Gilbert R.</creatorcontrib><creatorcontrib>Evans, Ronald C.</creatorcontrib><creatorcontrib>Bunch, Thomas D.</creatorcontrib><creatorcontrib>Beever, Jonathan E.</creatorcontrib><creatorcontrib>Call, Jay W.</creatorcontrib><creatorcontrib>Taylor, William D.</creatorcontrib><creatorcontrib>Marshall, Michael R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Theriogenology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Shiquan</au><au>Cockett, Noelle E.</au><au>Miller, Janice M.</au><au>Shay, Tracy L.</au><au>Maciulis, Alma</au><au>Sutton, Diane L.</au><au>Foote, Warren C.</au><au>Holyoak, Gilbert R.</au><au>Evans, Ronald C.</au><au>Bunch, Thomas D.</au><au>Beever, Jonathan E.</au><au>Call, Jay W.</au><au>Taylor, William D.</au><au>Marshall, Michael R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polymorphic distribution of the ovine prion protein ( PrP) gene in scrapie-infected sheep flocks in which embryo transfer was used to circumvent the transmissions of scrapie</atitle><jtitle>Theriogenology</jtitle><addtitle>Theriogenology</addtitle><date>2002-04-15</date><risdate>2002</risdate><volume>57</volume><issue>7</issue><spage>1865</spage><epage>1875</epage><pages>1865-1875</pages><issn>0093-691X</issn><eissn>1879-3231</eissn><abstract>The genetic sequence of the ovine prion protein (
PrP) gene between codons 102 and 175 with emphasis on ovine
PrP gene codons 136 and 171 was determined, and the polymorphic distribution of the ovine
PrP gene in the scrapie-exposed Suffolk embryo donors and offspring from these donors that were transferred to scrapie-free recipient ewes was investigated in this study. The most common genotype was
AA
136
QQ
171 (70% and 63% in the donor and offspring flocks, respectively), which is considered a high risk genotype in US Suffolk sheep. Although embryos were collected from scrapie-positive donors and many embryos had the high risk genotype, no scrapie occurred in the resulting offspring. Based upon the results of this study, we conclude that vertical transmission of scrapie can be circumvented using embryo transfer procedures even when the offspring have the high risk genotype.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>12041690</pmid><doi>10.1016/S0093-691X(02)00673-8</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0093-691X |
| ispartof | Theriogenology, 2002-04, Vol.57 (7), p.1865-1875 |
| issn | 0093-691X 1879-3231 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71773100 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Alleles Animals DNA sequence Embryo transfer Embryo Transfer - veterinary Female Gene Frequency Genotype Infectious Disease Transmission, Vertical Ovine prion protein gene (ovine PrP gene) Polymorphism, Genetic Prions - genetics Scrapie Scrapie - genetics Scrapie - prevention & control Scrapie - transmission Sheep Suffolk Tissue and Organ Harvesting - methods Tissue and Organ Harvesting - veterinary |
| title | Polymorphic distribution of the ovine prion protein ( PrP) gene in scrapie-infected sheep flocks in which embryo transfer was used to circumvent the transmissions of scrapie |
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