Cellular growth and rearrangement during the development of the mammalian organ of Corti
The sensory epithelium of the mammalian cochlea, the organ of Corti, is comprised of ordered rows of cells, including inner and outer hair cells. Recent results suggest that physical changes in the overall size and shape of the cochlear duct, including possible convergence and extension, could play...
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| Veröffentlicht in: | Developmental dynamics 2004-04, Vol.229 (4), p.802-812 |
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| creator | McKenzie, Erynn Krupin, Alison Kelley, Matthew W. |
| description | The sensory epithelium of the mammalian cochlea, the organ of Corti, is comprised of ordered rows of cells, including inner and outer hair cells. Recent results suggest that physical changes in the overall size and shape of the cochlear duct, including possible convergence and extension, could play a role in the development of this pattern. To examine this hypothesis, changes in cell size and distribution were determined for different regions of the cochlea duct during embryonic development. In addition, changes in the spatial distribution of sensory precursor cells were determined at different developmental time points based on expression of p27kip1. Unique changes in luminal surface area, cell density, and number of cell contacts were observed for each region of the duct. Moreover, the spatial distribution of p27kip1‐positive cells changed from short and broad early in development, to long and narrow. These results are consistent with the hypothesis that convergence and extension plays a role in cellular patterning within the organ of Corti. Developmental Dynamics 229:802–812, 2004. Published 2004 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/dvdy.10500 |
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Recent results suggest that physical changes in the overall size and shape of the cochlear duct, including possible convergence and extension, could play a role in the development of this pattern. To examine this hypothesis, changes in cell size and distribution were determined for different regions of the cochlea duct during embryonic development. In addition, changes in the spatial distribution of sensory precursor cells were determined at different developmental time points based on expression of p27kip1. Unique changes in luminal surface area, cell density, and number of cell contacts were observed for each region of the duct. Moreover, the spatial distribution of p27kip1‐positive cells changed from short and broad early in development, to long and narrow. These results are consistent with the hypothesis that convergence and extension plays a role in cellular patterning within the organ of Corti. Developmental Dynamics 229:802–812, 2004. 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Recent results suggest that physical changes in the overall size and shape of the cochlear duct, including possible convergence and extension, could play a role in the development of this pattern. To examine this hypothesis, changes in cell size and distribution were determined for different regions of the cochlea duct during embryonic development. In addition, changes in the spatial distribution of sensory precursor cells were determined at different developmental time points based on expression of p27kip1. Unique changes in luminal surface area, cell density, and number of cell contacts were observed for each region of the duct. Moreover, the spatial distribution of p27kip1‐positive cells changed from short and broad early in development, to long and narrow. These results are consistent with the hypothesis that convergence and extension plays a role in cellular patterning within the organ of Corti. Developmental Dynamics 229:802–812, 2004. Published 2004 Wiley‐Liss, Inc.</description><subject>Animals</subject><subject>Cell Count</subject><subject>Cell Cycle Proteins - metabolism</subject><subject>cochlea</subject><subject>Cochlear Duct - cytology</subject><subject>Cochlear Duct - embryology</subject><subject>convergent extension</subject><subject>Cyclin-Dependent Kinase Inhibitor p27</subject><subject>Embryo, Mammalian - cytology</subject><subject>Embryo, Mammalian - metabolism</subject><subject>hair cell</subject><subject>Hair Cells, Auditory, Inner - metabolism</subject><subject>Hair Cells, Auditory, Outer - metabolism</subject><subject>Mice</subject><subject>Morphogenesis</subject><subject>Organ of Corti - cytology</subject><subject>Organ of Corti - embryology</subject><subject>p27kip1</subject><subject>Tumor Suppressor Proteins - metabolism</subject><issn>1058-8388</issn><issn>1097-0177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAQQIMo7rp68QdITx6E6qRJk-xRun6B4EVFTyVtJt1KP9a03WX_ve12wZteMsPweJBHyDmFawoQ3Ji12fZbCHBAphTm0gcq5eGwh8pXTKkJOWmaLwBQgtNjMqEh8EACn5KPCIuiK7TzMldv2qWnK-M51M7pKsMSq9YzncurzGuX6BlcY1Gvdufa7k6lLktd5LryapcNr_Wi2rX5KTmyumjwbD9n5O3-7jV69J9fHp6i22c_5UEAfsINF9wyllBhA6Mp1yqVAkUiU8OEthaYtYYzLpGnClJl5wpC5NIYFHLOZuRy9K5c_d1h08Zl3qT9p3SFddfEsk8RsED9CwYgGKVqMF6NYOrqpnFo45XLS-22MYV4CB4PweNd8B6-2Fu7pETzi-4L9wAdgU1e4PYPVbx4X3yO0h_Th4v9</recordid><startdate>200404</startdate><enddate>200404</enddate><creator>McKenzie, Erynn</creator><creator>Krupin, Alison</creator><creator>Kelley, Matthew W.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>200404</creationdate><title>Cellular growth and rearrangement during the development of the mammalian organ of Corti</title><author>McKenzie, Erynn ; Krupin, Alison ; Kelley, Matthew W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4220-b4d464f33b16f2da14a8c76e6b7cd36aff03ffd4347e4c80c8f9805e47dde6793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Cell Count</topic><topic>Cell Cycle Proteins - metabolism</topic><topic>cochlea</topic><topic>Cochlear Duct - cytology</topic><topic>Cochlear Duct - embryology</topic><topic>convergent extension</topic><topic>Cyclin-Dependent Kinase Inhibitor p27</topic><topic>Embryo, Mammalian - cytology</topic><topic>Embryo, Mammalian - metabolism</topic><topic>hair cell</topic><topic>Hair Cells, Auditory, Inner - metabolism</topic><topic>Hair Cells, Auditory, Outer - metabolism</topic><topic>Mice</topic><topic>Morphogenesis</topic><topic>Organ of Corti - cytology</topic><topic>Organ of Corti - embryology</topic><topic>p27kip1</topic><topic>Tumor Suppressor Proteins - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McKenzie, Erynn</creatorcontrib><creatorcontrib>Krupin, Alison</creatorcontrib><creatorcontrib>Kelley, Matthew W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Developmental dynamics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McKenzie, Erynn</au><au>Krupin, Alison</au><au>Kelley, Matthew W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cellular growth and rearrangement during the development of the mammalian organ of Corti</atitle><jtitle>Developmental dynamics</jtitle><addtitle>Dev Dyn</addtitle><date>2004-04</date><risdate>2004</risdate><volume>229</volume><issue>4</issue><spage>802</spage><epage>812</epage><pages>802-812</pages><issn>1058-8388</issn><eissn>1097-0177</eissn><abstract>The sensory epithelium of the mammalian cochlea, the organ of Corti, is comprised of ordered rows of cells, including inner and outer hair cells. 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| subjects | Animals Cell Count Cell Cycle Proteins - metabolism cochlea Cochlear Duct - cytology Cochlear Duct - embryology convergent extension Cyclin-Dependent Kinase Inhibitor p27 Embryo, Mammalian - cytology Embryo, Mammalian - metabolism hair cell Hair Cells, Auditory, Inner - metabolism Hair Cells, Auditory, Outer - metabolism Mice Morphogenesis Organ of Corti - cytology Organ of Corti - embryology p27kip1 Tumor Suppressor Proteins - metabolism |
| title | Cellular growth and rearrangement during the development of the mammalian organ of Corti |
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