Blockade of interleukin-6 receptor suppresses reactive astrogliosis and ameliorates functional recovery in experimental spinal cord injury

Endogenous neural stem/progenitor cells (NSPCs) have recently been shown to differentiate exclusively into astrocytes, the cells that are involved in glial scar formation after spinal cord injury (SCI). The microenvironment of the spinal cord, especially the inflammatory cytokines that dramatically...

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Veröffentlicht in:	Journal of neuroscience research 2004-04, Vol.76 (2), p.265-276
Hauptverfasser:	Okada, S., Nakamura, M., Mikami, Y., Shimazaki, T., Mihara, M., Ohsugi, Y., Iwamoto, Y., Yoshizaki, K., Kishimoto, T., Toyama, Y., Okano, H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Antibodies - therapeutic use Astrocytes - drug effects Behavior, Animal Blotting, Western - methods Bromodeoxyuridine - metabolism CD11b Antigen - metabolism Cell Count - methods Cells, Cultured Disease Models, Animal DNA-Binding Proteins - metabolism ELAV Proteins Female Glial Fibrillary Acidic Protein - metabolism glial scar IL-6 Immunohistochemistry - methods In Vitro Techniques inflammation Interleukin-6 - pharmacology Locomotion - drug effects Male Mice Mice, Inbred C57BL Nerve Tissue Proteins - metabolism neural stem/progenitor cells Psychomotor Performance - drug effects Receptors, Interleukin-6 - antagonists & inhibitors Receptors, Interleukin-6 - immunology Recovery of Function RNA-Binding Proteins - metabolism Spinal Cord Injuries - metabolism Spinal Cord Injuries - pathology Spinal Cord Injuries - therapy spinal cord injury Staining and Labeling STAT3 Transcription Factor Trans-Activators - metabolism
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