Novel transcripts of fibroblast growth factor receptor 3 reveal aberrant splicing and activation of cryptic splice sequences in colorectal cancer

A nested reverse transcription-PCR analysis of FGFR3 from human colorectal carcinomas revealed novel mutant transcripts caused by aberrant splicing and activation of cryptic splice sequences. Two aberrantly spliced transcripts were detected with high frequency in 50% of 36 primary tumors and in 60%...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2000-08, Vol.60 (15), p.4049-4052
Hauptverfasser:	JANG, J.-H, SHIN, K.-H, PARK, Y.-J, LEE, R. J, MCKEEHAN, W. L, PARK, J.-G
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing - genetics Amino Acid Sequence Biological and medical sciences Codon, Nonsense Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Down-Regulation Exons - genetics FGFR3 gene Frameshift Mutation Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Regulation, Neoplastic Humans Medical sciences Molecular Sequence Data Peptide Chain Termination, Translational Protein-Tyrosine Kinases Receptor, Fibroblast Growth Factor, Type 3 Receptors, Fibroblast Growth Factor - biosynthesis Receptors, Fibroblast Growth Factor - genetics RNA, Messenger - genetics RNA, Messenger - metabolism Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumor Cells, Cultured Tumors
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