Loss of ACTH expression in cultured human corticotroph macroadenoma cells is consistent with loss of the POMC gene signal sequence

The proopiomelanocortin (POMC) gene is highly expressed in the pituitary gland where the resulting mRNA of 1200 base pairs (bp) gives rise to a full-length protein sequence. In peripheral tissues however both shorter and longer POMC variants have been described, these include for example placental t...

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Veröffentlicht in:	Molecular and cellular endocrinology 2002-03, Vol.189 (1), p.51-57
Hauptverfasser:	Rees, D.A., Hepburn, P.J., McNicol, A.M., Francis, K., Jasani, B., Lewis, M.D., Farrell, W.E., Lewis, B.M., Scanlon, M.F., Ham, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	ACTH Adenoma Adrenocorticotropic Hormone - genetics Adrenocorticotropic Hormone - metabolism Cells, Cultured Culture Exon Exons - genetics Human pituitary Humans In Situ Hybridization Pituitary Gland - cytology Pituitary Neoplasms POMC Pro-Opiomelanocortin - chemistry Pro-Opiomelanocortin - genetics Pro-Opiomelanocortin - metabolism Protein Sorting Signals RNA, Messenger - genetics RNA, Messenger - metabolism Signal
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