Circumvention of nuclear factor kappaB-induced chemoresistance by cytoplasmic-targeted anthracyclines

Nuclear factor kappaB (NF-kappaB) has been implicated in inducible chemoresistance against anthracyclines. In an effort to improve the cytotoxicity of anthracyclines while reducing their cardiotoxic effects, we have developed a novel class of extranuclear-localizing 14-O-acylanthracyclines that bind...

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Veröffentlicht in:	Molecular pharmacology 2004-04, Vol.65 (4), p.1038-1047
Hauptverfasser:	Bilyeu, Jennifer D, Panta, Ganesh R, Cavin, Lakita G, Barrett, Christina M, Turner, Eddie J, Sweatman, Trevor W, Israel, Mervyn, Lothstein, Leonard, Arsura, Marcello
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anthracyclines - pharmacology Ataxia Telangiectasia Mutated Proteins bcl-X Protein Cell Cycle Proteins Cell Line Cytoplasm - drug effects Cytoplasm - enzymology DNA Damage DNA-Binding Proteins Doxorubicin - analogs & derivatives Doxorubicin - pharmacology Enzyme Activation I-kappa B Kinase Mice NF-kappa B - metabolism Protein Kinase C - metabolism Protein Kinase C-delta Protein-Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins c-bcl-2 - metabolism Transfection Tumor Suppressor Protein p53 - metabolism Tumor Suppressor Proteins
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